Atlas of Genetics and Cytogenetics in Oncology and Haematology
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
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ABI1 (Abl-Interactor 1)
| Identity |
| Other names | E3B1 |
| eps8 SH3 domain binding protein | |
| SSH3BP1 | |
| HGNC (Hugo) | ABI1 |
| LocusID (NCBI) | 10006 |
| Location | 10p12.1 |
| Location_base_pair | Starts at 27035525 and ends at 27150016 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Local_order | centromeric to the AF10 gene |
 | |
| ABI1 (10p11) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| DNA/RNA |
| Transcription | different splicings (and different names for the gene) |
| Protein |
| Description | 387 (ABI1) to 508 (e3B1) amino acids; 43 to 72 kDa; NH2- an homeodomain homologous region and a SH3 domain -COOH |
| Expression | wide, in adults and in the embryo |
| Localisation | cytosol |
| Function | cell growth inhibitor; interacts withENL, another fusion partner of MLL, by binding it through its SH3 domain; the mouse Abi-1 protein is an AB-binding protein that suppresses v-ABL transforming activity |
| Implicated in |
| Entity | t(10;11)(p11.2;q23) acute non lymphoblastic leukemia (ANLL) --> MLL- ABI1 |
| Note | only one case to date |
| Disease | M4 ANLL in an infant |
| Oncogenesis | MLL-ABI1 displays a transcriptional transactivator activity similar to MLL-ENL; they may act in a common oncogenic pathway |
| Other Leukemias implicated (Data extracted from papers in the Atlas) |
| Leukemias | 11q23ChildAMLID1615 | 11q23ID1030 | 11q23secondLeukID1131 |
| External links |
| Bibliography |
| Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. |
| Biesova Z, Piccoli C, Wong WT |
| Oncogene. 1997 ; 14 (2) : 233-241. |
| PMID 9010225 |
| ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23). |
| Taki T, Shibuya N, Taniwaki M, Hanada R, Morishita K, Bessho F, Yanagisawa M, Hayashi Y |
| Blood. 1998 ; 92 (4) : 1125-1130. |
| PMID 9694699 |
| Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton. |
| Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L |
| The Journal of biological chemistry. 1998 ; 273 (22) : 13681-13692. |
| PMID 9593709 |
| ENL, the MLL fusion partner in t(11;19), binds to the c-ABL interactor protein 1 (ABI1) that is fused to MLL in t(10;11). |
| Garcia Cuellar MP, Schreiner S, Birke M, Hamacher M, Slany RK |
| Blood. 1999 ; 94 (numero Suppl 1). |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 04-2000 | Jean-Loup Huret |
| Citation |
| This paper should be referenced as such : |
| Huret, JL |
| ABI1 (Abl-Interactor 1) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):55-56. |
| Free journal version : [ pdf ] [ DOI ] |
| URL : http://AtlasGeneticsOncology.org/Genes/ABI1ID233.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Tue Feb 17 20:30:32 CET 2015 |
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