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ADIPOR1 (adiponectin receptor 1)

Written2009-05Virginia Kaklamani, Christos Mantzoros
Department of Medicine, Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 676 N St Clair St. Suite 850, Chicago, IL 60611, USA (VK); Department of Medicine, Division of Endocrinology, Harvard University Medical School, Beth Israel Deaconess Medical Center, E/St 816, 330 Brookline Ave, Boston, MA02215, USA (CM)

(Note : for Links provided by Atlas : click)

Identity

Other aliasACDCR1
CGI-45
CGI45
FLJ25385
FLJ42464
PAQR1
TESBP1A
LocusID (NCBI) 51094
Atlas_Id 44512
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADIPOR1 (1q32.1) / APEH (3p21.31)ADIPOR1 (1q32.1) / CYB5R1 (1q32.1)ADIPOR1 (1q32.1) / RGS8 (1q25.3)
BICC1 (10q21.1) / ADIPOR1 (1q32.1)FAM155A (13q33.3) / ADIPOR1 (1q32.1)

DNA/RNA

 
  Genomic structure of ADIPOR1. Blue boxes indicate exons.
Description Eight exons spanning 17.5 kb. Transcription is from telomere to centromere.
Transcription Transcription produces 11 different mRNAs, 10 alternatively spliced variants and 1 unspliced form. There are 6 probable alternative promoters, 2 non overlapping alternative last exons and 8 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 6 cassette exons, overlapping exons with different boundaries. 9 spliced and the unspliced mRNAs putatively encode good proteins, altogether 9 different isoforms (3 complete, 6 partial), some containing Hly-III related proteins domain (Pfam) some transmembrane domains (Psort2); 1 of the 3 complete proteins appears to be secreted. The remaining mRNA variant (spliced) appears not to encode a good protein.

Protein

Description Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that counteracts the effects of insulin.
Expression Widely expressed. Highly expressed in adipose tissue and skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. We have also shown expression in normal and cancerous breast tissue as well as in other cancers such as prostate, colon, endometrial. It is also present in several cell lines.
Localisation ADIPOR1 localizes to the plasma membrane.
Function Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARa ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity for globular adiponectin but low-affinity for full-length adiponectin.
Homology The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 amino acids. Human and mouse ADIPOR1 share 96.8% identity.

Mutations

Note One functional polymorphism has been described. Rs7539542 has been found to modulate expression of ADIPOR1 mRNA (Soccio et al., 2006).

Implicated in

Note
  
Entity Breast Cancer
Note Adiponectin has been implicated in breast cancer. The breast cancer cell lines MCF-7, MDB-MB-231 and T47D were found to express both adiponectin receptors ADIPOR1/ADIPOR2 (Dieudonne et al., 2006; Korner et al., 2007) and exposure of T47D cells to adiponectin, significantly inhibited their proliferation (Korner et al., 2007). rs2232853 CT genotype (OR=1.67; 95% CI 1.23-2.26) and the combination of rs7539542 GC (OR=0.59; 95% CI 0.36-0.98) and CC genotypes (OR=0.57; 95% CI 0.35-0.94) were significantly associated with breast cancer risk. The high expressing rs2241766 G allele (GG and GT genotypes) was associated with decreased breast cancer risk (OR=0.64; 95% CI 0.49-0.83). The low expressing rs1501299 G allele was associated with increased breast cancer risk: for TG: OR=1.59; 95% CI 1.03-2.48, for GG: OR= 1.80; 95% CI 1.14-2.85.
  
  
Entity Colon Cancer
Note Adiponectin has also been implicated in colon cancer risk. rs266729 polymorphism was significantly associated with colon cancer risk: the RR for the GG/CG genotypes was rs266729 was associated with a reduced colorectal cancer risk: O.R. 0.73, 95% CI (0.53-0.99) (Kaklamani et al., 2008).
  
  
Entity Endometrial Cancer
Note Adiponectin levels have been shown to correlate with endometrial cancer risk (Petridou et al., 2003; Dal et al., 2004).
  
  
Entity Prostate Cancer
Note Adiponectin levels have been shown to correlate with prostate cancer risk (Barb et al., 2007; Arisan et al., 2009).
  

Bibliography

Serum adipocytokine levels in prostate cancer patients.
Arisan ED, Arisan S, Atis G, Palavan-Unsal N, Ergenekon E.
Urol Int. 2009;82(2):203-8. Epub 2009 Mar 19.
PMID 19322011
 
Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence.
Barb D, Williams CJ, Neuwirth AK, Mantzoros CS.
Am J Clin Nutr. 2007 Sep;86(3):s858-66.
PMID 18265479
 
Circulating adiponectin and endometrial cancer risk.
Dal Maso L, Augustin LS, Karalis A, Talamini R, Franceschi S, Trichopoulos D, Mantzoros CS, La Vecchia C.
J Clin Endocrinol Metab. 2004 Mar;89(3):1160-3.
PMID 15001602
 
Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells.
Dieudonne MN, Bussiere M, Dos Santos E, Leneveu MC, Giudicelli Y, Pecquery R.
Biochem Biophys Res Commun. 2006 Jun 23;345(1):271-9. Epub 2006 Apr 27.
PMID 16678125
 
Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B.
JAMA. 2008 Oct 1;300(13):1523-31.
PMID 18827209
 
Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies.
Korner A, Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Williams CJ, Kaprara A, Bullen J, Neuwirth A, Tseleni S, Mitsiades N, Kiess W, Mantzoros CS.
J Clin Endocrinol Metab. 2007 Mar;92(3):1041-8. Epub 2006 Dec 27.
PMID 17192291
 
Plasma adiponectin concentrations in relation to endometrial cancer: a case-control study in Greece.
Petridou E, Mantzoros C, Dessypris N, Koukoulomatis P, Addy C, Voulgaris Z, Chrousos G, Trichopoulos D.
J Clin Endocrinol Metab. 2003 Mar;88(3):993-7.
PMID 12629074
 
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes.
Soccio T, Zhang YY, Bacci S, Mlynarski W, Placha G, Raggio G, Di Paola R, Marucci A, Johnstone MT, Gervino EV, Abumrad NA, Klein S, Trischitta V, Doria A.
Diabetes. 2006 Oct;55(10):2763-70.
PMID 17003341
 

Citation

This paper should be referenced as such :
Kaklamani, V ; Mantzoros, C
ADIPOR1 (adiponectin receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(4):334-335.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/ADIPOR1ID44512ch1q32.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(q25;q32) ADIPOR1/RGS8
ADIPOR1/CYB5R1 (1q32)


External links

Nomenclature
Cards
AtlasADIPOR1ID44512ch1q32.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)51094
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:27:24 CEST 2018

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