| Description | The ALDH2 protein is 517 amino acid long, has a molecular weight of 56 Kd, and forms a homotetramer. |
| Expression | ALDH2 is expressed in several human tissues with the highest levels found in liver. Screening of human cDNA libraries has revealed that ALDH2 transcripts are present in human liver, kidney, heart, stomach, colon, muscle, ovary, pancreas, lung, prostate, ear, eye, marrow, gall bladder, testis, thyroid, retina, adipose, adrenal gland, blood, brain, breast, placenta, uterus, B-cells, fetal brain, tonsil, foreskin, nervous normal and also in lung tumor, bladder tumor, nervous tumor. |
| Localisation | Mitochondrial matrix |
| Function | Conversion of aldehydes to acids via the reaction: ALDEHYDE + NAD + H2O = ACID + NADH |
| Homology | ALDH2 belongs to the aldehyde dehydrogenase gene superfamily . |
| Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. |
| Yoshida A, Ikawa M, Hsu LC, Tani K |
| Alcohol (Fayetteville, N.Y.). 1985 ; 2 (1) : 103-106. |
| PMID 4015823 |
| |
| Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. |
| Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J |
| Cancer research. 1995 ; 55 (24) : 6038-6039. |
| PMID 8521389 |
| |
| Investigation of genetic risk factors associated with alcoholism. |
| Harada S, Okubo T, Tsutsumi M, Takase S, Muramatsu T |
| Alcoholism, clinical and experimental research. 1996 ; 20 (9 Suppl) : 293A-296A. |
| PMID 8986225 |
| |
| Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. |
| Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J |
| Cancer research. 1995 ; 55 (24) : 6038-6039. |
| PMID 8521389 |
| |
| Effects of worldwide population subdivision on ALDH2 linkage disequilibrium. |
| Peterson RJ, Goldman D, Long JC |
| Genome research. 1999 ; 9 (9) : 844-852. |
| PMID 10508843 |
| |
| Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. |
| Murata M, Tagawa M, Watanabe S, Kimura H, Takeshita T, Morimoto K |
| Japanese journal of cancer research : Gann. 1999 ; 90 (7) : 711-719. |
| PMID 10470282 |
| |
| Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients. |
| Muto M, Hitomi Y, Ohtsu A, Ebihara S, Yoshida S, Esumi H |
| Gut. 2000 ; 47 (2) : 256-261. |
| PMID 10896918 |
| |
| Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. |
| Vasiliou V, Pappa A |
| Pharmacology. 2000 ; 61 (3) : 192-198. |
| PMID 10971205 |
| |