| | ABL1 (9q34.12) / CBFB (16q22.1) | C16orf70 (16q22.1) / CBFB (16q22.1) | CBFB (16q22.1) / ATP13A3 (3q29) |
| |
CBFB (16q22.1) / CBFB (16q22.1) | CBFB (16q22.1) / CES4A (16q22.1) | CBFB (16q22.1) / FUK (16q22.1) |
| |
CBFB (16q22.1) / HNRNPA2B1 (7p15.2) | CBFB (16q22.1) / MRPL42 (12q22) | CBFB (16q22.1) / MUTYH (1p34.1) |
| |
CBFB (16q22.1) / MYH11 (16p13.11) | CBFB (16q22.1) / NAE1 (16q22.1) | CBFB (16q22.1) / NDE1 (16p13.11) |
| |
MYH11 (16p13.11) / CBFB (16q22.1) |
| Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. |
| Castilla LH, Wijmenga C, Wang Q, Stacy T, Speck NA, Eckhaus M, Marín-Padilla M, Collins FS, Wynshaw-Boris A, Liu PP |
| Cell. 1996 ; 87 (4) : 687-696. |
| PMID 8929537 |
| |
| Identification of yeast artificial chromosomes containing the inversion 16 p-arm breakpoint associated with acute myelomonocytic leukemia. |
| Liu P, Claxton DF, Marlton P, Hajra A, Siciliano J, Freedman M, Chandrasekharappa SC, Yanagisawa K, Stallings RL, Collins FS |
| Blood. 1993 ; 82 (3) : 716-721. |
| PMID 8338941 |
| |
| Molecular cloning and characterization of PEBP2 beta, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2 alpha. |
| Ogawa E, Inuzuka M, Maruyama M, Satake M, Naito-Fujimoto M, Ito Y, Shigesada K |
| Virology. 1993 ; 194 (1) : 314-331. |
| PMID 8386878 |
| |
| PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. |
| Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y |
| Proceedings of the National Academy of Sciences of the United States of America. 1993 ; 90 (14) : 6859-6863. |
| PMID 8341710 |
| |
| The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. |
| Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe AH, Speck NA |
| Cell. 1996 ; 87 (4) : 697-708. |
| PMID 8929538 |
| |
| Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. |
| Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA |
| Molecular and cellular biology. 1993 ; 13 (6) : 3324-3339. |
| PMID 8497254 |
| |
| Acute myelogenous leukemia: a disorder of gene splicing? |
| van der Reijden BA, van Ommen GJ, Hagemeijer A, Breuning MH |
| Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1996 ; 10 (2) : 204-206. |
| PMID 8637227 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | CBFB 1539 |
| Cards |
|---|
| Atlas | CBFbID45 |
| Entrez_Gene (NCBI) | CBFB 865 core-binding factor subunit beta |
| Aliases | PEBP2B |
| GeneCards (Weizmann) | CBFB |
| Ensembl hg19 (Hinxton) | ENSG00000067955 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000067955 [Gene_View] ENSG00000067955 [Sequence] chr16:67029147-67101055 [Contig_View] CBFB [Vega] |
| ICGC DataPortal | ENSG00000067955 |
| TCGA cBioPortal | CBFB |
| AceView (NCBI) | CBFB |
| Genatlas (Paris) | CBFB |
| WikiGenes | 865 |
| SOURCE (Princeton) | CBFB |
| Genetics Home Reference (NIH) | CBFB |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CBFB - chr16:67029147-67101055 + 16q22.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CBFB - 16q22.1 [Description] (hg19-Feb_2009) |
| Ensembl | CBFB - 16q22.1 [CytoView hg19] CBFB - 16q22.1 [CytoView hg38] |
| Mapping of homologs : NCBI | CBFB [Mapview hg19] CBFB [Mapview hg38] |
| OMIM | 121360 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA020956 AF294326 AK290462 AK291834 AK311084 |
| RefSeq transcript (Entrez) | NM_001755 NM_022845 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CBFB |
| Cluster EST : Unigene | Hs.460988 [ NCBI ] |
| CGAP (NCI) | Hs.460988 |
| Alternative Splicing Gallery | ENSG00000067955 |
| Gene Expression | CBFB [ NCBI-GEO ] CBFB [ EBI - ARRAY_EXPRESS ]
CBFB [ SEEK ] CBFB [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CBFB [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 865 |
| GTEX Portal (Tissue expression) | CBFB |
| Human Protein Atlas | ENSG00000067955-CBFB [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13951 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q13951 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13951 |
| Splice isoforms : SwissVar | Q13951 |
| PhosPhoSitePlus | Q13951 |
| Domains : Interpro (EBI) | CBF_beta CBF_bsu_sf |
| Domain families : Pfam (Sanger) | CBF_beta (PF02312) |
| Domain families : Pfam (NCBI) | pfam02312 |
| Conserved Domain (NCBI) | CBFB |
| DMDM Disease mutations | 865 |
| Blocks (Seattle) | CBFB |
| PDB (SRS) | 1CL3 1E50 1H9D 4N9F |
| PDB (PDBSum) | 1CL3 1E50 1H9D 4N9F |
| PDB (IMB) | 1CL3 1E50 1H9D 4N9F |
| PDB (RSDB) | 1CL3 1E50 1H9D 4N9F |
| Structural Biology KnowledgeBase | 1CL3 1E50 1H9D 4N9F |
| SCOP (Structural Classification of Proteins) | 1CL3 1E50 1H9D 4N9F |
| CATH (Classification of proteins structures) | 1CL3 1E50 1H9D 4N9F |
| Superfamily | Q13951 |
| Human Protein Atlas [tissue] | ENSG00000067955-CBFB [tissue] |
| Peptide Atlas | Q13951 |
| HPRD | 00418 |
| IPI | IPI00016746 IPI00024871 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13951 |
| IntAct (EBI) | Q13951 |
| FunCoup | ENSG00000067955 |
| BioGRID | CBFB |
| STRING (EMBL) | CBFB |
| ZODIAC | CBFB |
| Ontologies - Pathways |
|---|
| QuickGO | Q13951 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II protein polyubiquitination RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding osteoblast differentiation regulation of cytokine-mediated signaling pathway DNA binding DNA-binding transcription factor activity transcription coregulator activity transcription coactivator activity protein binding nucleoplasm regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter membrane core-binding factor complex lymphocyte differentiation myeloid cell differentiation regulation of Wnt signaling pathway regulation of intracellular estrogen receptor signaling pathway negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation sequence-specific DNA binding regulation of regulatory T cell differentiation regulation of keratinocyte differentiation regulation of myeloid cell differentiation regulation of megakaryocyte differentiation positive regulation of transcription by RNA polymerase II cell maturation regulation of B cell receptor signaling pathway definitive hemopoiesis regulation of hematopoietic stem cell differentiation regulation of bicellular tight junction assembly |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II protein polyubiquitination RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding osteoblast differentiation regulation of cytokine-mediated signaling pathway DNA binding DNA-binding transcription factor activity transcription coregulator activity transcription coactivator activity protein binding nucleoplasm regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter membrane core-binding factor complex lymphocyte differentiation myeloid cell differentiation regulation of Wnt signaling pathway regulation of intracellular estrogen receptor signaling pathway negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation sequence-specific DNA binding regulation of regulatory T cell differentiation regulation of keratinocyte differentiation regulation of myeloid cell differentiation regulation of megakaryocyte differentiation positive regulation of transcription by RNA polymerase II cell maturation regulation of B cell receptor signaling pathway definitive hemopoiesis regulation of hematopoietic stem cell differentiation regulation of bicellular tight junction assembly |
| REACTOME | Q13951 [protein] |
| REACTOME Pathways | R-HSA-8951936 [pathway] |
| NDEx Network | CBFB |
| Atlas of Cancer Signalling Network | CBFB |
| Wikipedia pathways | CBFB |
| Orthology - Evolution |
|---|
| OrthoDB | 865 |
| GeneTree (enSembl) | ENSG00000067955 |
| Phylogenetic Trees/Animal Genes : TreeFam | CBFB |
| HOVERGEN | Q13951 |
| HOGENOM | Q13951 |
| Homologs : HomoloGene | CBFB |
| Homology/Alignments : Family Browser (UCSC) | CBFB |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | CBFB/ATP13A3 [16q22.1/3q29] |
| Fusion : Mitelman | CBFB/CES4A [16q22.1/16q22.1] [t(16;16)(q22;q22)] |
| Fusion : Mitelman | CBFB/MYH11 [16q22.1/16p13.11] [ins(16)(q22p13p13)] [ins(16;16)(q22;p13p13)] |
| [inv(16)(p13q22)] [t(16;16)(p13;q22)] |
| Fusion Portal | CBFB 16q22.1 ATP13A3 3q29 HNSC |
| Fusion Portal | CBFB 16q22.1 CES4A 16q22.1 HNSC |
| Fusion : TICdb | CBFB [16q22.1] - MYH11 [16p13.11] |
| Fusion : Quiver | CBFB |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CBFB [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CBFB |
| dbVar | CBFB |
| ClinVar | CBFB |
| 1000_Genomes | CBFB |
| Exome Variant Server | CBFB |
| ExAC (Exome Aggregation Consortium) | ENSG00000067955 |
| GNOMAD Browser | ENSG00000067955 |
| Varsome Browser | CBFB |
| Genetic variants : HAPMAP | 865 |
| Genomic Variants (DGV) | CBFB [DGVbeta] |
| DECIPHER | CBFB [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CBFB |
| Mutations |
|---|
| ICGC Data Portal | CBFB |
| TCGA Data Portal | CBFB |
| Broad Tumor Portal | CBFB |
| OASIS Portal | CBFB [ Somatic mutations - Copy number] |
| Cancer Gene: Census | CBFB |
| Somatic Mutations in Cancer : COSMIC | CBFB [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CBFB |
| intOGen Portal | CBFB |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CBFB |
| DgiDB (Drug Gene Interaction Database) | CBFB |
| DoCM (Curated mutations) | CBFB (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CBFB (select a term) |
| intoGen | CBFB |
| NCG5 (London) | CBFB |
| Cancer3D | CBFB(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 121360 |
| Orphanet | 13846 |
| DisGeNET | CBFB |
| Medgen | CBFB |
| Genetic Testing Registry | CBFB
|
| NextProt | Q13951 [Medical] |
| TSGene | 865 |
| GENETests | CBFB |
| Target Validation | CBFB |
| Huge Navigator |
CBFB [HugePedia] |
| snp3D : Map Gene to Disease | 865 |
| BioCentury BCIQ | CBFB |
| ClinGen | CBFB (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 865 |
| Chemical/Pharm GKB Gene | PA26114 |
| Clinical trial | CBFB |
| Miscellaneous |
|---|
| canSAR (ICR) | CBFB (select the gene name) |
| Other database | http://cancergenome.broadinstitute.org/index.php?tgene=CBFB |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 121 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CBFB |
| EVEX | CBFB |
| GoPubMed | CBFB |
| iHOP | CBFB |
