| Written | 2000-04 | Nick CP Cross |
| Wessex Regional Genetics Laboratory Salisbury District Hospital Salisbury, SP2 8BJ, UK |
| Identity |
| Alias_names | CDX3 |
| caudal type homeo box transcription factor 2 | |
| Other alias | |
| HGNC (Hugo) | CDX2 |
| LocusID (NCBI) | 1045 |
| Atlas_Id | 326 |
| Location | 13q12.2 [Link to chromosome band 13q12] |
| Location_base_pair | Starts at 27960918 and ends at 27969368 bp from pter ( according to hg19-Feb_2009) [Mapping CDX2.png] |
| Local_order | IPF1-CDX2- FLT3 -FLT1 |
 | |
| CDX2 (13q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| CDX2 (13q12.2) / ETV6 (12p13.2) | ETV6 (12p13.2) / CDX2 (13q12.2) |
| DNA/RNA |
| Description | Three exons transcribed from telomere to centromere. |
| Protein |
| Description | 311 amino acid protein of MW 33kDa. Class I homeobox gene related to Drosophila caudal. |
| Expression | Nuclear protein normally expressed almost exclusively in the intestine, where it plays a role in the proliferation and differentiation of intestinal epithelial cells. |
| Mutations |
| Somatic | Found to be mutated in rare cases of colorectal carcinoma |
| Implicated in |
| Note | |
| Entity | t(12;13)(p13;q12) acute myeloid leukemia --> ETV6/ CDX2 |
| Abnormal Protein | Fusion of ETV6 exon 2 to CDX2 exon 2. The predicted protein contains the N-terminal region of ETV6 38 fused to the entire homeobox of CDX2. The single case described that harbours this fusion also expressed normal CDX2, which is not normally expressed in haemopoietic cells. |
| Bibliography |
| Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). |
| Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts IA, Goldman JM, Cross NC |
| Blood. 1999 ; 93 (3) : 1025-1031. |
| PMID 9920852 |
| Cloning and chromosome assignment of the human CDX2 gene. |
| Drummond F, Putt W, Fox M, Edwards YH |
| Annals of human genetics. 1997 ; 61 (Pt 5) : 393-400. |
| PMID 9459001 |
| CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. |
| Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B |
| Oncogene. 1998 ; 17 (5) : 657-659. |
| PMID 9704932 |
| CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. |
| da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW |
| Oncogene. 1999 ; 18 (35) : 5010-5014. |
| PMID 10490837 |
| Citation |
| This paper should be referenced as such : |
| Cross, NCP |
| CDX2 (caudal-related homeobox 2) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(2):60-61. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/CDX2ID326.html |
| Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ] |
|
12p rearrangements in CLL
t(12;13)(p12;q12-14) ETV6/CDX2 t(12;13)(p13;q12) ETV6/FLT3 |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ] |
|
Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma
|
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon May 14 12:34:43 CEST 2018 |
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