Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). |
Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts IA, Goldman JM, Cross NC |
Blood. 1999 ; 93 (3) : 1025-1031. |
PMID 9920852 |
|
Cloning and chromosome assignment of the human CDX2 gene. |
Drummond F, Putt W, Fox M, Edwards YH |
Annals of human genetics. 1997 ; 61 (Pt 5) : 393-400. |
PMID 9459001 |
|
CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. |
Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B |
Oncogene. 1998 ; 17 (5) : 657-659. |
PMID 9704932 |
|
CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. |
da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW |
Oncogene. 1999 ; 18 (35) : 5010-5014. |
PMID 10490837 |
|
| Nomenclature |
HGNC (Hugo) | CDX2 1806 |
| Cards |
Atlas | CDX2ID326 |
Entrez_Gene (NCBI) | CDX2 caudal type homeobox 2 |
Aliases | CDX-3; CDX2/AS; CDX3 |
GeneCards (Weizmann) | CDX2 |
Ensembl hg19 (Hinxton) | ENSG00000165556 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000165556 [Gene_View]  ENSG00000165556 [Sequence] chr13:27960918-27969368 [Contig_View] CDX2 [Vega] |
ICGC DataPortal | ENSG00000165556 |
TCGA cBioPortal | CDX2 |
AceView (NCBI) | CDX2 |
Genatlas (Paris) | CDX2 |
SOURCE (Princeton) | CDX2 |
Genetics Home Reference (NIH) | CDX2 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | CDX2 - chr13:27960918-27969368 - 13q12.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | CDX2 - 13q12.2 [Description] (hg19-Feb_2009) |
GoldenPath | CDX2 - 13q12.2 [CytoView hg19] CDX2 - 13q12.2 [CytoView hg38] |
ImmunoBase | ENSG00000165556 |
genome Data Viewer NCBI | CDX2 [Mapview hg19] |
OMIM | 600297 |
| Gene and transcription |
Genbank (Entrez) | AK000205 BC014461 BI085425 KJ081251 KJ531444 |
RefSeq transcript (Entrez) | NM_001265 NM_001354700 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | CDX2 |
Alternative Splicing Gallery | ENSG00000165556 |
Gene Expression | CDX2 [ NCBI-GEO ] CDX2 [ EBI - ARRAY_EXPRESS ]
CDX2 [ SEEK ] CDX2 [ MEM ] |
Gene Expression Viewer (FireBrowse) | CDX2 [ Firebrowse - Broad ] |
Genevisible | Expression of CDX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 1045 |
GTEX Portal (Tissue expression) | CDX2 |
Human Protein Atlas | ENSG00000165556-CDX2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q99626 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q99626 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q99626 |
Splice isoforms : SwissVar | Q99626 |
PhosPhoSitePlus | Q99626 |
Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
Domains : Interpro (EBI) | Caudal_activation_dom Homeobox-like_sf Homeobox_CS Homeobox_dom Homeobox_metazoa HTH_motif |
Domain families : Pfam (Sanger) | Caudal_act (PF04731) Homeodomain (PF00046) |
Domain families : Pfam (NCBI) | pfam04731 pfam00046 |
Domain families : Smart (EMBL) | HOX (SM00389) |
Conserved Domain (NCBI) | CDX2 |
Blocks (Seattle) | CDX2 |
PDB (RSDB) | 5LTY 6ES2 6ES3 |
PDB Europe | 5LTY 6ES2 6ES3 |
PDB (PDBSum) | 5LTY 6ES2 6ES3 |
PDB (IMB) | 5LTY 6ES2 6ES3 |
Structural Biology KnowledgeBase | 5LTY 6ES2 6ES3 |
SCOP (Structural Classification of Proteins) | 5LTY 6ES2 6ES3 |
CATH (Classification of proteins structures) | 5LTY 6ES2 6ES3 |
Superfamily | Q99626 |
Human Protein Atlas [tissue] | ENSG00000165556-CDX2 [tissue] |
Peptide Atlas | Q99626 |
HPRD | 02622 |
IPI | IPI00016928 IPI01024878 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q99626 |
IntAct (EBI) | Q99626 |
BioGRID | CDX2 |
STRING (EMBL) | CDX2 |
ZODIAC | CDX2 |
| Ontologies - Pathways |
QuickGO | Q99626 |
Ontology : AmiGO | "negative regulation of transcription by RNA polymerase II nuclear chromatin condensed nuclear chromosome RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific blood vessel development trophectodermal cell differentiation DNA-binding transcription factor activity transcription corepressor activity nucleus nucleoplasm regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of cell proliferation methyl-CpG binding endosome to lysosome transport embryo development animal organ morphogenesis anterior/posterior axis specification regulation of somitogenesis transcriptional repressor complex cell differentiation somatic stem cell population maintenance establishment or maintenance of epithelial cell apical/basal polarity positive regulation of cell differentiation positive regulation of transcription, DNA-templated intestinal epithelial cell differentiation labyrinthine layer development" |
Ontology : EGO-EBI | "negative regulation of transcription by RNA polymerase II nuclear chromatin condensed nuclear chromosome RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific blood vessel development trophectodermal cell differentiation DNA-binding transcription factor activity transcription corepressor activity nucleus nucleoplasm regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of cell proliferation methyl-CpG binding endosome to lysosome transport embryo development animal organ morphogenesis anterior/posterior axis specification regulation of somitogenesis transcriptional repressor complex cell differentiation somatic stem cell population maintenance establishment or maintenance of epithelial cell apical/basal polarity positive regulation of cell differentiation positive regulation of transcription, DNA-templated intestinal epithelial cell differentiation labyrinthine layer development" |
REACTOME | Q99626 [protein] |
REACTOME Pathways | R-HSA-381771 [pathway] |
NDEx Network | CDX2 |
Atlas of Cancer Signalling Network | CDX2 |
Wikipedia pathways | CDX2 |
| Orthology - Evolution |
OrthoDB | 1045 |
GeneTree (enSembl) | ENSG00000165556 |
Phylogenetic Trees/Animal Genes : TreeFam | CDX2 |
HOGENOM | Q99626 |
Homologs : HomoloGene | CDX2 |
Homology/Alignments : Family Browser (UCSC) | CDX2 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | ETV6/CDX2 [12p13.2/13q12.2]   |
Fusion : TICdb | ETV6 [12p13.2] - CDX2 [13q12.2] |
Fusion : Fusion_Hub | ABL1--CDX2 CDK8--CDX2 CDX2--ETV6 ETV6--CDX2 SLC7A1--CDX2 USP12--CDX2 |
Fusion : Quiver | CDX2 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | CDX2 [hg38] |
dbVar | CDX2 |
ClinVar | CDX2 |
Monarch | CDX2 |
1000_Genomes | CDX2 |
Exome Variant Server | CDX2 |
GNOMAD Browser | ENSG00000165556 |
Varsome Browser | CDX2 |
Genomic Variants (DGV) | CDX2 [DGVbeta] |
DECIPHER | CDX2 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | CDX2 |
| Mutations |
ICGC Data Portal | CDX2 |
TCGA Data Portal | CDX2 |
Broad Tumor Portal | CDX2 |
OASIS Portal | CDX2 [ Somatic mutations - Copy number] |
Cancer Gene: Census | CDX2 |
Somatic Mutations in Cancer : COSMIC | CDX2 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | CDX2 |
Mutations and Diseases : HGMD | CDX2 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search CDX2 |
DgiDB (Drug Gene Interaction Database) | CDX2 |
DoCM (Curated mutations) | CDX2 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | CDX2 (select a term) |
intoGen | CDX2 |
OncoKB | CDX2 |
NCG6 (London) | select CDX2 |
Cancer3D | CDX2(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 600297 |
Orphanet | |
DisGeNET | CDX2 |
Medgen | CDX2 |
Genetic Testing Registry | CDX2
|
NextProt | Q99626 [Medical] |
GENETests | CDX2 |
Target Validation | CDX2 |
Huge Navigator |
CDX2 [HugePedia] |
ClinGen | CDX2 |
| Clinical trials, drugs, therapy |
---|
MyCancerGenome | CDX2 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA26352 |
Pharos | Q99626 |
Clinical trial | CDX2 |
| Miscellaneous |
---|
canSAR (ICR) | CDX2 (select the gene name) |
Harmonizome | CDX2 |
DataMed Index | CDX2 |
| Probes |
---|
| Litterature |
---|
PubMed | 327 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | CDX2 |