| Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). |
| Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts IA, Goldman JM, Cross NC |
| Blood. 1999 ; 93 (3) : 1025-1031. |
| PMID 9920852 |
| |
| Cloning and chromosome assignment of the human CDX2 gene. |
| Drummond F, Putt W, Fox M, Edwards YH |
| Annals of human genetics. 1997 ; 61 (Pt 5) : 393-400. |
| PMID 9459001 |
| |
| CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. |
| Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B |
| Oncogene. 1998 ; 17 (5) : 657-659. |
| PMID 9704932 |
| |
| CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. |
| da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW |
| Oncogene. 1999 ; 18 (35) : 5010-5014. |
| PMID 10490837 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | CDX2 1806 |
| Cards |
|---|
| Atlas | CDX2ID326 |
| Entrez_Gene (NCBI) | CDX2 1045 caudal type homeobox 2 |
| Aliases | CDX-3; CDX2/AS; CDX3 |
| GeneCards (Weizmann) | CDX2 |
| Ensembl hg19 (Hinxton) | ENSG00000165556 [Gene_View] chr13:28536205-28543505 [Contig_View] CDX2 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000165556 [Gene_View] chr13:28536205-28543505 [Contig_View] CDX2 [Vega] |
| ICGC DataPortal | ENSG00000165556 |
| TCGA cBioPortal | CDX2 |
| AceView (NCBI) | CDX2 |
| Genatlas (Paris) | CDX2 |
| WikiGenes | 1045 |
| SOURCE (Princeton) | CDX2 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | CDX2 - chr13:28536205-28543505 - 13q12.2 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | CDX2 - 13q12.2 [Description] (hg38-Dec_2013) |
| Ensembl | CDX2 - 13q12.2 [CytoView hg19] CDX2 - 13q12.2 [CytoView hg38] |
| Mapping of homologs : NCBI | CDX2 [Mapview hg19] CDX2 [Mapview hg38] |
| OMIM | 600297 |
| Gene and transcription |
|---|
| Genbank (Entrez) | BC014461 BI085425 DQ893626 EU176674 KJ081251 |
| RefSeq transcript (Entrez) | NM_001265 |
| RefSeq genomic (Entrez) | NC_000013 NC_018924 NT_024524 NW_004929388 |
| Consensus coding sequences : CCDS (NCBI) | CDX2 |
| Cluster EST : Unigene | Hs.740844 [ NCBI ] |
| CGAP (NCI) | Hs.740844 |
| Alternative Splicing Gallery | ENSG00000165556 |
| Gene Expression | CDX2 [ NCBI-GEO ] CDX2 [ EBI - ARRAY_EXPRESS ]
CDX2 [ SEEK ] CDX2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CDX2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1045 |
| GTEX Portal (Tissue expression) | CDX2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q99626 (Uniprot) |
| NextProt | Q99626 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q99626 |
| Splice isoforms : SwissVar | Q99626 (Swissvar) |
| PhosPhoSitePlus | Q99626 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Caudal_activation_dom Homeobox_CS Homeobox_dom Homeobox_metazoa Homeodomain-like HTH_motif |
| Domain families : Pfam (Sanger) | Caudal_act (PF04731) Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam04731 pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| DMDM Disease mutations | 1045 |
| Blocks (Seattle) | CDX2 |
| Superfamily | Q99626 |
| Human Protein Atlas | ENSG00000165556 |
| Peptide Atlas | Q99626 |
| HPRD | 02622 |
| IPI | IPI00016928 IPI01024878 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q99626 |
| IntAct (EBI) | Q99626 |
| FunCoup | ENSG00000165556 |
| BioGRID | CDX2 |
| STRING (EMBL) | CDX2 |
| ZODIAC | CDX2 |
| Ontologies - Pathways |
|---|
| QuickGO | Q99626 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter condensed nuclear chromosome RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development trophectodermal cell differentiation transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus nucleoplasm transcription from RNA polymerase II promoter positive regulation of cell proliferation endosome to lysosome transport organ morphogenesis anterior/posterior axis specification regulation of somitogenesis transcriptional repressor complex cell differentiation somatic stem cell population maintenance establishment or maintenance of epithelial cell apical/basal polarity positive regulation of cell differentiation positive regulation of transcription, DNA-templated intestinal epithelial cell differentiation labyrinthine layer development |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter condensed nuclear chromosome RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding blood vessel development trophectodermal cell differentiation transcription factor activity, sequence-specific DNA binding transcription corepressor activity nucleus nucleoplasm transcription from RNA polymerase II promoter positive regulation of cell proliferation endosome to lysosome transport organ morphogenesis anterior/posterior axis specification regulation of somitogenesis transcriptional repressor complex cell differentiation somatic stem cell population maintenance establishment or maintenance of epithelial cell apical/basal polarity positive regulation of cell differentiation positive regulation of transcription, DNA-templated intestinal epithelial cell differentiation labyrinthine layer development |
| REACTOME | Q99626 [protein] |
| REACTOME Pathways | R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) [pathway] |
| NDEx Network | CDX2 |
| Atlas of Cancer Signalling Network | CDX2 |
| Wikipedia pathways | CDX2 |
| Orthology - Evolution |
|---|
| OrthoDB | 1045 |
| GeneTree (enSembl) | ENSG00000165556 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDX2 |
| Homologs : HomoloGene | CDX2 |
| Homology/Alignments : Family Browser (UCSC) | CDX2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | ETV6/CDX2 [12p13.2/13q12.2] [t(12;13)(p13;q12)] |
| Fusion : TICdb | ETV6 [12p13.2] - CDX2 [13q12.2] |
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | CDX2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CDX2 |
| dbVar | CDX2 |
| ClinVar | CDX2 |
| 1000_Genomes | CDX2 |
| Exome Variant Server | CDX2 |
| ExAC (Exome Aggregation Consortium) | CDX2 (select the gene name) |
| Genetic variants : HAPMAP | 1045 |
| Genomic Variants (DGV) | CDX2 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | CDX2 |
| TCGA Data Portal | CDX2 |
| Broad Tumor Portal | CDX2 |
| OASIS Portal | CDX2 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | CDX2 |
| Somatic Mutations in Cancer : COSMIC | CDX2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CDX2 |
| DgiDB (Drug Gene Interaction Database) | CDX2 |
| DoCM (Curated mutations) | CDX2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CDX2 (select a term) |
| intoGen | CDX2 |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 13:28536205-28543505 ENSG00000165556 |
| CONAN: Copy Number Analysis | CDX2 |
| Mutations and Diseases : HGMD | CDX2 |
| OMIM | 600297 |
| Medgen | CDX2 |
| Genetic Testing Registry | CDX2
|
| NextProt | Q99626 [Medical] |
| TSGene | 1045 |
| GENETests | CDX2 |
| Huge Navigator |
CDX2 [HugePedia] |
| snp3D : Map Gene to Disease | 1045 |
| BioCentury BCIQ | CDX2 |
| ClinGen | CDX2 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1045 |
| Chemical/Pharm GKB Gene | PA26352 |
| Clinical trial | CDX2 |
| Miscellaneous |
|---|
| canSAR (ICR) | CDX2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 249 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CDX2 |
| EVEX | CDX2 |
| GoPubMed | CDX2 |
| iHOP | CDX2 |
