Atlas of Genetics and Cytogenetics in Oncology and Haematology
CDX2 (caudal-related homeobox 2)
| Identity |
| Other names | CDX3 |
| HGNC | CDX2 |
| Location | 13q12.3 |
| Location_base_pair | Starts at 27434278 and ends at 27441317 bp from pter ( according to hg18-Mar_2006). |
| Local_order | IPF1-CDX2- FLT3 -FLT1 |
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| CDX2 (13q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it | |
| DNA/RNA |
| Description | Three exons transcribed from telomere to centromere. |
| Protein |
| Description | 311 amino acid protein of MW 33kDa. Class I homeobox gene related to Drosophila caudal. |
| Expression | Nuclear protein normally expressed almost exclusively in the intestine, where it plays a role in the proliferation and differentiation of intestinal epithelial cells. |
| Mutations |
| Somatic | Found to be mutated in rare cases of colorectal carcinoma |
| Implicated in |
| Entity | t(12;13)(p13;q12) acute non lymphocytic leukaemia --> ETV6/ CDX2 |
| Abnormal Protein | Fusion of ETV6 exon 2 to CDX2 exon 2. The predicted protein contains the N-terminal region of ETV6 38 fused to the entire homeobox of CDX2. The single case described that harbours this fusion also expressed normal CDX2, which is not normally expressed in haemopoietic cells. |
| External links |
| Bibliography |
| Cloning and chromosome assignment of the human CDX2 gene. |
| Drummond F, Putt W, Fox M, Edwards YH |
| Annals of human genetics. 1997 ; 61 (Pt 5) : 393-400. |
| PMID 9459001 |
| CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. |
| Wicking C, Simms LA, Evans T, Walsh M, Chawengsaksophak K, Beck F, Chenevix-Trench G, Young J, Jass J, Leggett B, Wainwright B |
| Oncogene. 1998 ; 17 (5) : 657-659. |
| PMID 9704932 |
| Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). |
| Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, Roberts IA, Goldman JM, Cross NC |
| Blood. 1999 ; 93 (3) : 1025-1031. |
| PMID 9920852 |
| CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling. |
| da Costa LT, He TC, Yu J, Sparks AB, Morin PJ, Polyak K, Laken S, Vogelstein B, Kinzler KW |
| Oncogene. 1999 ; 18 (35) : 5010-5014. |
| PMID 10490837 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 04-2000 | Nick CP Cross |
| Citation |
| This paper should be referenced as such : |
| Cross NCP . CDX2 (caudal-related homeobox 2). Atlas Genet Cytogenet Oncol Haematol. April 2000 . URL : http://AtlasGeneticsOncology.org/Genes/CDX2ID326.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Dec 6 17:54:39 2008 |
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