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CENPF (centromere protein F, 350/400ka (mitosin))

Written2008-04Hideo Shigeishi, Koichiro Higashikawa, Nobuyuki Kamata
Department of Oral, Maxillofacial Surgery, Hiroshima University, Kasumi, Hiroshima 734-855, Japan

(Note : for Links provided by Atlas : click)

Identity

Other aliasAH antigen
CENF
hcp-1
Mitosin
PRO1779
LocusID (NCBI) 1063
Atlas_Id 40057
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at and ends at bp from pter
Local_order Chromosome 1, 61,381 bases, 5'- 212,843,155 - 212,904,535 -3': strand (+)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CENPF (1q41) / CENPF (1q41)CENPF (1q41) / HS2ST1 (1p22.3)CENPF (1q41) / SUSD4 (1q41)
GALT (9p13.3) / CENPF (1q41)PDE3A (12p12.2) / CENPF (1q41)PPP1CC (12q24.11) / CENPF (1q41)
RPL23 (17q12) / CENPF (1q41)

DNA/RNA

 
  A schematic diagram of the CENPF gene. The exon numbers are labeled.
Description The CENPF gene structure consists of twenty exons, ranging from 92 to 3,404 bp, and nineteen introns, ranging from approximately 1 to approximately 10 kb.
Transcription 10,294 bp mRNA; 9630 bp open reading frame.
Pseudogene No pseudogene.

Protein

 
  A schematics representing the domain structure of full length CENPF. NLS, nuclear localization signal.
Description The gene encodes a protein associated with the centromere-kinetochore complex, 3210 amino acids (aa), 367594 Da, containing internal repeats, coiled-coil (potential) and NLS (potential).
Expression Breast, eye, gastro-intestinal tract, heart, liver, lymph node, ovary, placenta, skin, stomach, testis.
Localisation Nucleus matrix, but not in the nucleolus, reorganization to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis.
Function CenpF is recruited to kinetochore early in mitosis after recruitment of Bub1 and modulates kinetochore association of certain mitotic proteins including BubR1 for kinetochore assembly.
CenpF that has a CAAX motif in their C-terminal is target for farnesylation. This modification changes is necessary for CenpF function at the G2/M transition. CenpE and CenpF have a significant role in the antitumor activity of farnesyl transferase inhibitors due to their importance in normal cell division.
Homology no

Implicated in

Note
  
Entity Head and neck squamous cell carcinoma
Disease CENPF gene amplification and overexpression were observed in head and neck squamous cell carcinoma (HNSCC). Up-regulation of CenpF, especially by gene amplification, suggests the possibility that increased CenpF protein levels could influence tumorigenesis particularly at early stages of tumor development. In addition, over-expression of CenpF is significantly correlated with poor prognosis of HNSCC. CenpF expression is able to use clinically as a proliferation marker in oral epithelia.
  
  
Entity Breast cancer
Disease Over-expression of CENPF mRNA was associated with larger tumor size as well as estrogen receptor (ER) - negative, high grade tumors. CENPF mRNA expression correlated significantly with worse overall survival and a decreased probability of remaining metastasis-free. CenpF expression was also correlated with telomerase activity, cyclin E over-expression, c-Myc amplification and nuclear expression of surviving, indicating that CenpF is a good biomarker for proliferation of breast cancer. ver-expressing In addition, a significant proportion of brest cancer cells over-expressing CENPF were aneuploid, supporting evidence for the relation between CenpF expression and chromosomal instability.
  
  
Entity Astrocytic gliomas
Disease In microarray and real-time RT-PCR analyses, CENPF mRNA levels significantly increased in primary astrocytic gliomas. Interestingly, secondary glioblastomas demonstrated higher CENPF mRNA levels than primary glioblastomas. However, amplification of the gene was not found.
  
  
Entity Salivary gland tumor
Disease CenpF expression was significantly correlated with Ki-67 labeling index in primary malignant salivary gland tumor by immunohistochemical study. In addition, CENPF mRNA level was associated with clinical stage. The data suggests that CenpF expression is a candidate for biomarker of proliferation of salivary tumor.
  

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CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer.
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Cenp-F (mitosin) is more than a mitotic marker.
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Citation

This paper should be referenced as such :
Shigeishi, H ; Higashikawa, K ; Kamata, N
CENPF (centromere protein F, 350/400ka (mitosin))
Atlas Genet Cytogenet Oncol Haematol. 2009;13(2):106-109.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CENPFID40057ch1q41.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;16)(q32;p13) NDE1/PDGFRB


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;2)(q41;p23) CENPF/ALK


External links

Nomenclature
Cards
AtlasCENPFID40057ch1q41.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)1063
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Oct 18 17:31:46 CEST 2018

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