CCNE1 (cyclin E1)

2003-02-01  

Identity

HGNC
LOCATION
19q12
LOCUSID
ALIAS
CCNE,pCCNE1
FUSION GENES

Other Information

Locus ID:

NCBI: 898
MIM: 123837
HGNC: 1589
Ensembl: ENSG00000105173

Variants:

dbSNP: 898
ClinVar: 898
TCGA: ENSG00000105173
COSMIC: CCNE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105173ENST00000262643P24864
ENSG00000105173ENST00000357943C9J2U0
ENSG00000105173ENST00000444983P24864
ENSG00000105173ENST00000575243I3L1Q9
ENSG00000105173ENST00000576532I3L413

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Prostate cancerKEGGko05215
Small cell lung cancerKEGGko05222
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Small cell lung cancerKEGGhsa05222
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Signal TransductionREACTOMER-HSA-162582
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21REACTOMER-HSA-187577
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesREACTOMER-HSA-69200
G1/S-Specific TranscriptionREACTOMER-HSA-69205
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates Cell CycleREACTOMER-HSA-8849470
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestREACTOMER-HSA-6804116

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196175342009A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase.205
125539122003Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.199
209724382010A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.188
151971782004Deregulation of cyclin E in human cells interferes with prereplication complex assembly.111
172182762007Kinase-independent function of cyclin E.88
229456452013Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress.76
203367842010Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer.66
208377052010DDX3 regulates cell growth through translational control of cyclin E1.61
163226932006Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.57
194707242009Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.57

Citation

Dessen P

CCNE1 (cyclin E1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/956/ccne1-(cyclin-e1)