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DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

Written2008-05Eileen Friedman
Upstate Medical University, State University of New York, Syracuse, New York 13210, USA

(Note : for Links provided by Atlas : click)

Identity

Alias_namesdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Alias_symbol (synonym)MIRK
Other alias
HGNC (Hugo) DYRK1B
LocusID (NCBI) 9149
Atlas_Id 43235
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40315987 and ends at 40324873 bp from pter ( according to hg19-Feb_2009)  [Mapping DYRK1B.png]
Fusion genes
(updated 2016)
DYRK1B (19q13.2) / SENP3 (17p13.1)

DNA/RNA

Description 11 exons and 10 introns encompassing 8.8kb.
Transcription Start at exon 1 encodes major active form p69, with alternative splicing in exon 9 giving rise to kinase inactive p62, and with alternative splicing within intron 1-2 giving rise to p75 in skeletal muscle.
Pseudogene None reported

Protein

Note Serine/threonine kinase activated by intramolecular phosphorylation on tyrosine.
Description 629 amino acids.
Expression Widely expressed at low levels, with elevated expression in muscle and testis.
Function Mediates myoblast differentiation.

Mutations

Note None in SW480 colon cancer cells, none reported.

Implicated in

Note
  
Entity Ductal adenocarcinoma of the pancreas
Note Active kinase in pancreatic cancer cell lines.
Disease Present in 89% of cases by immunocytochemistry (25 of 28 cases)
Cytogenetics 19q13 amplicon in 10% of cases
Hybrid/Mutated Gene None reported
Abnormal Protein None reported
Oncogenesis Embryonic knockout is viable and has no reported phenotype
  
  
Entity Rhabdomyosarcoma
Note Overexpressed in 12 of 16 cases; active kinase in rhabdomyosarcoma cell lines
  

Breakpoints

Note None reported

Bibliography

The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.
Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E.
Cancer Res. 2006 Apr 15;66(8):4149-58.
PMID 16618736
 
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
Jin K, Park S, Ewton DZ, Friedman E.
Cancer Res. 2007 Aug 1;67(15):7247-55.
PMID 17671193
 
Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Lee K, Deng X, Friedman E.
Cancer Res. 2000 Jul 1;60(13):3631-7.
PMID 10910078
 
Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.
Mercer SE, Ewton DZ, Shah S, Naqvi A, Friedman E.
Cancer Res. 2006 May 15;66(10):5143-50.
PMID 16707437
 

Citation

This paper should be referenced as such :
Friedman, E
DYRK1B (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(4):263-264.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DYRK1BID43235ch19q13.html


External links

Nomenclature
HGNC (Hugo)DYRK1B   3092
Cards
AtlasDYRK1BID43235ch19q13
Entrez_Gene (NCBI)DYRK1B  9149  dual specificity tyrosine phosphorylation regulated kinase 1B
AliasesAOMS3; MIRK
GeneCards (Weizmann)DYRK1B
Ensembl hg19 (Hinxton)ENSG00000105204 [Gene_View]  chr19:40315987-40324873 [Contig_View]  DYRK1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000105204 [Gene_View]  chr19:40315987-40324873 [Contig_View]  DYRK1B [Vega]
ICGC DataPortalENSG00000105204
TCGA cBioPortalDYRK1B
AceView (NCBI)DYRK1B
Genatlas (Paris)DYRK1B
WikiGenes9149
SOURCE (Princeton)DYRK1B
Genetics Home Reference (NIH)DYRK1B
Genomic and cartography
GoldenPath hg19 (UCSC)DYRK1B  -     chr19:40315987-40324873 -  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)DYRK1B  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblDYRK1B - 19q13.2 [CytoView hg19]  DYRK1B - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIDYRK1B [Mapview hg19]  DYRK1B [Mapview hg38]
OMIM604556   615812   
Gene and transcription
Genbank (Entrez)AF205861 AK074971 AK302127 BC009688 BC018751
RefSeq transcript (Entrez)NM_004714 NM_006483 NM_006484
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_034145 NT_011109 NW_004929415 NW_009646206
Consensus coding sequences : CCDS (NCBI)DYRK1B
Cluster EST : UnigeneHs.130988 [ NCBI ]
CGAP (NCI)Hs.130988
Alternative Splicing GalleryENSG00000105204
Gene ExpressionDYRK1B [ NCBI-GEO ]   DYRK1B [ EBI - ARRAY_EXPRESS ]   DYRK1B [ SEEK ]   DYRK1B [ MEM ]
Gene Expression Viewer (FireBrowse)DYRK1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9149
GTEX Portal (Tissue expression)DYRK1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y463   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y463  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y463
Splice isoforms : SwissVarQ9Y463
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ9Y463
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)DYRK1B
DMDM Disease mutations9149
Blocks (Seattle)DYRK1B
SuperfamilyQ9Y463
Human Protein AtlasENSG00000105204
Peptide AtlasQ9Y463
HPRD05188
IPIIPI00000352   IPI00332215   IPI00215873   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y463
IntAct (EBI)Q9Y463
FunCoupENSG00000105204
BioGRIDDYRK1B
STRING (EMBL)DYRK1B
ZODIACDYRK1B
Ontologies - Pathways
QuickGOQ9Y463
Ontology : AmiGOtranscription coactivator activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  protein phosphorylation  myoblast fusion  peptidyl-tyrosine phosphorylation  positive regulation of transcription, DNA-templated  adipose tissue development  
Ontology : EGO-EBItranscription coactivator activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  protein phosphorylation  myoblast fusion  peptidyl-tyrosine phosphorylation  positive regulation of transcription, DNA-templated  adipose tissue development  
Pathways : BIOCARTASonic Hedgehog (Shh) Pathway [Genes]   
NDEx NetworkDYRK1B
Atlas of Cancer Signalling NetworkDYRK1B
Wikipedia pathwaysDYRK1B
Orthology - Evolution
OrthoDB9149
GeneTree (enSembl)ENSG00000105204
Phylogenetic Trees/Animal Genes : TreeFamDYRK1B
HOVERGENQ9Y463
HOGENOMQ9Y463
Homologs : HomoloGeneDYRK1B
Homology/Alignments : Family Browser (UCSC)DYRK1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerDYRK1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)DYRK1B
dbVarDYRK1B
ClinVarDYRK1B
1000_GenomesDYRK1B 
Exome Variant ServerDYRK1B
ExAC (Exome Aggregation Consortium)DYRK1B (select the gene name)
Genetic variants : HAPMAP9149
Genomic Variants (DGV)DYRK1B [DGVbeta]
DECIPHER (Syndromes)19:40315987-40324873  ENSG00000105204
CONAN: Copy Number AnalysisDYRK1B 
Mutations
ICGC Data PortalDYRK1B 
TCGA Data PortalDYRK1B 
Broad Tumor PortalDYRK1B
OASIS PortalDYRK1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICDYRK1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDDYRK1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch DYRK1B
DgiDB (Drug Gene Interaction Database)DYRK1B
DoCM (Curated mutations)DYRK1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)DYRK1B (select a term)
intoGenDYRK1B
NCG5 (London)DYRK1B
Cancer3DDYRK1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604556    615812   
Orphanet
MedgenDYRK1B
Genetic Testing Registry DYRK1B
NextProtQ9Y463 [Medical]
TSGene9149
GENETestsDYRK1B
Huge Navigator DYRK1B [HugePedia]
snp3D : Map Gene to Disease9149
BioCentury BCIQDYRK1B
ClinGenDYRK1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9149
Chemical/Pharm GKB GenePA27549
Clinical trialDYRK1B
Miscellaneous
canSAR (ICR)DYRK1B (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineDYRK1B
EVEXDYRK1B
GoPubMedDYRK1B
iHOPDYRK1B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:39:39 CET 2017

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