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DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

Written2008-05Eileen Friedman
Upstate Medical University, State University of New York, Syracuse, New York 13210, USA

(Note : for Links provided by Atlas : click)

Identity

Other aliasMIRK
LocusID (NCBI) 9149
Atlas_Id 43235
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DYRK1B (19q13.2) / SENP3 (17p13.1)

DNA/RNA

Description 11 exons and 10 introns encompassing 8.8kb.
Transcription Start at exon 1 encodes major active form p69, with alternative splicing in exon 9 giving rise to kinase inactive p62, and with alternative splicing within intron 1-2 giving rise to p75 in skeletal muscle.
Pseudogene None reported

Protein

Note Serine/threonine kinase activated by intramolecular phosphorylation on tyrosine.
Description 629 amino acids.
Expression Widely expressed at low levels, with elevated expression in muscle and testis.
Function Mediates myoblast differentiation.

Mutations

Note None in SW480 colon cancer cells, none reported.

Implicated in

Note
  
Entity Ductal adenocarcinoma of the pancreas
Note Active kinase in pancreatic cancer cell lines.
Disease Present in 89% of cases by immunocytochemistry (25 of 28 cases)
Cytogenetics 19q13 amplicon in 10% of cases
Hybrid/Mutated Gene None reported
Abnormal Protein None reported
Oncogenesis Embryonic knockout is viable and has no reported phenotype
  
  
Entity Rhabdomyosarcoma
Note Overexpressed in 12 of 16 cases; active kinase in rhabdomyosarcoma cell lines
  

Breakpoints

Note None reported

Bibliography

The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.
Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E.
Cancer Res. 2006 Apr 15;66(8):4149-58.
PMID 16618736
 
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
Jin K, Park S, Ewton DZ, Friedman E.
Cancer Res. 2007 Aug 1;67(15):7247-55.
PMID 17671193
 
Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Lee K, Deng X, Friedman E.
Cancer Res. 2000 Jul 1;60(13):3631-7.
PMID 10910078
 
Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.
Mercer SE, Ewton DZ, Shah S, Naqvi A, Friedman E.
Cancer Res. 2006 May 15;66(10):5143-50.
PMID 16707437
 

Citation

This paper should be referenced as such :
Friedman, E
DYRK1B (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(4):263-264.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/DYRK1BID43235ch19q13.html


External links

Nomenclature
Cards
AtlasDYRK1BID43235ch19q13.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)9149
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:34:25 CEST 2018

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