PSIP1 (PC4 and SFRS1 interacting protein 1)
2007-03-01 Cristina Morerio , Claudio Panarello AffiliationDipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, Largo G. Gaslini 5, 16147 Genoa, Italy
Identity
HGNC
LOCATION
9p22.3
LOCUSID
ALIAS
DFS70,LEDGF,PAIP,PSIP2,p52,p75
FUSION GENES
DNA/RNA
Description
The gene contains at least 15 exons and 14 introns.
Transcription
Two alternative splice variants: p75 and p52.
Proteins
Description
530 amino acids (p75), 333 amino acids (p52); N-term - PWWP (proline-tryptophan-tryptophan-proline) domain NLS (nuclear localization signal) AT-hook-like Coiled coil IBD (integrase binding domain) HTH1 (helix-turn-helix DNA binding motif) HTH2 C-term.
Expression
Expression of PSIP1 has been reported to be increased in human breast and bladder cancer, prostate tumorsand benign prostate hyperplasia.
Localisation
nuclear.
Function
Transcriptional regulation of stress-associated genes, mRNA splicing and cell survival. The involvement of PSIP1 (LEDGF) has been reported in human immunodeficiency virus type-1 (HIV-1) integration, autoimmune disorders, and neurogenesis. Recent data reveal LEDGF as an oncogenic protein that controls a caspase-independent lysosomal cell death pathway.
Homology
PSIP1 belongs to the hepatoma-derived growth factor (HDGF) family of proteins that contain a well conserved N-terminal amino acid sequence known as the HATH (homologous to amino terminus of HDGF) region.
Implicated in
Entity name
Note
acute non lymphoblastic leukemia (AML), one case of transformed .
Hybrid gene
5NUP98 - 3PSIP1.
Fusion protein
fuses the GLFG repeat domains of NUP98 to the COOH-terminus of PSIP1.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11103774 | 2000 | t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF). | Ahuja HG et al |
| 12407101 | 2003 | HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. | Cherepanov P et al |
| 15389814 | 2005 | Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis. | Daniels T et al |
| 17363574 | 2007 | Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer. | Daugaard M et al |
| 15982735 | 2005 | NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia. | Grand FH et al |
| 11737860 | 2001 | Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation. | Hussey DJ et al |
| 15725483 | 2005 | t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia. | Morerio C et al |
| 10721720 | 2000 | Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. | Singh DP et al |
| 16318853 | 2006 | DNA binding domains and nuclear localization signal of LEDGF: contribution of two helix-turn-helix (HTH)-like domains and a stretch of 58 amino acids of the N-terminal to the trans-activation potential of LEDGF. | Singh DP et al |
| 16980622 | 2006 | Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. | Sutherland HG et al |
| 12181742 | 2002 | Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. | Wu X et al |
Other Information
Locus ID:
NCBI: 11168
MIM: 603620
HGNC: 9527
Ensembl: ENSG00000164985
Variants:
dbSNP: 11168
ClinVar: 11168
TCGA: ENSG00000164985
COSMIC: PSIP1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38191578 | 2024 | PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity. | 1 |
| 38191578 | 2024 | PSIP1/LEDGF reduces R-loops at transcription sites to maintain genome integrity. | 1 |
| 34225636 | 2022 | The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis. | 3 |
| 34225636 | 2022 | The LncRNA MIR155HG is Upregulated by SP1 in Melanoma Cells and Drives Melanoma Progression via Modulating the MiR-485-3p/PSIP1 Axis. | 3 |
| 33477970 | 2021 | Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. | 4 |
| 34070855 | 2021 | LEDGF/p75 Is Required for an Efficient DNA Damage Response. | 12 |
| 34634812 | 2021 | Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75. | 9 |
| 34685704 | 2021 | The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. | 8 |
| 33477970 | 2021 | Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival. | 4 |
| 34070855 | 2021 | LEDGF/p75 Is Required for an Efficient DNA Damage Response. | 12 |
| 34634812 | 2021 | Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75. | 9 |
| 34685704 | 2021 | The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. | 8 |
| 31819277 | 2020 | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. | 33 |
| 31819277 | 2020 | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. | 33 |
| 29166758 | 2019 | Clinical significance of anti-dense fine speckled 70 antibody in patients with fibromyalgia. | 6 |
Citation
Cristina Morerio ; Claudio Panarello
PSIP1 (PC4 and SFRS1 interacting protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-03-01
Online version: http://atlasgeneticsoncology.org/gene/405/psip1-(pc4-and-sfrs1-interacting-protein-1)
