Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ERG (v-ets erythroblastosis virus E26 oncogene like (avian))

Identity

Other nameserg-3
p55
HGNC (Hugo) ERG
LocusID (NCBI) 2078
Location 21q22.2
Location_base_pair Starts at 39751950 and ends at 40033704 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.

DNA/RNA

 
  ERG gene locus on the q-arm of chromosome 21 (21q22.2) spanning from 39751949 to 40033704 (according to UCSC genome browser, Feb. 2009 GRCh37/hg19, and Ensemble, Aug. 2010).
Description The ERG gene belongs to the erythroblast transformation-specific (ETS) family of transcriptions factors. The ERG gene (ETS related gene 1) is located on chromosome 21, and consists of 17 exons, approximately 300 kb DNA in length.
Transcription The ERG gene forms 20 known transcripts (ranging from 560 to 5034 bp in length), amongst which 15 are coding for proteins, and 5 are non-coding. 8 alternative splice variants are known.
Pseudogene No observed pseudogenes.

Protein

Description Amongst the 20 known transcripts of the ERG gene, 15 are protein coding. The 15 proteins range from 171 to 486 amino acids in length, and up to 55 kDa in weight.
Expression On the protein level, ERG is mainly expressed in the nucleus and is rarely seen in the cytoplasm. Basically, in the GNF SymAtlas database, major ERG expression was found to be in CD34+ cells (that include both hematopoietic stem cells and endothelial cells). In detail, ERG is reported to be expressed during early T and B cell development, and down-regulated in later stages of B and T cell differentiation. Also, ERG is expressed in platelets, megakaryoblastic cell lines, primary megakaryoblastic leukemia (AMKL or M7-AML) in Down syndrome patients. Furthermore, ERG is strongly expressed in ERG gene rearranged prostate tissue (both in prostatic cancer tissue and adjacent prostatic intraepithelial neoplasia lesions). Of note, using immunohistochemistry, ERG expression is regularly observed in lymphocytes and small blood vessels.
Localisation Predominantely nuclear and rarely cytoplasmic.
Function The ERG protein is a member of the ETS-family and is known to bind to purine-rich sequences. ERG and other members of the same family are downstream regulators of mitogenic signal transduction pathways. They are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. At the DNA level, isoforms of ERG are known to regulate methylation. Further, ERG is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. Moreover, hematopoesis, as well as the differentiation and maturation of megakaryocytic cells are regulated by ERG. Overexpression of the ERG protein is suggested to aid in forming solid tumors. However, the exact molecular mechanisms of ERG as a transcription factor are still unknown.
Homology A member of the ETS transcription factors, most homologous to FLI1.

Mutations

Note No known mutations.

Implicated in

Entity Ewing's sarcoma
Prognosis The prognostic relevance of an ERG gene fusion or an ERG overexpression in Ewing's sarcoma (EWS-ETS fusion type) is yet to be determined. So far, no prognostic relevance could be shown.
Hybrid/Mutated Gene If a gene fusion occurs in Ewing's sarcoma, most frequently it is a fusion of EWS to FLI-1 (in app. 85% of cases) or ERG (in app. 10% of cases). Other ETS genes rarely serve as EWS gene fusion partners (in app. 5% of cases).
Abnormal Protein The EWS gene fuses with the carboxyl terminal of ERG containing the ETS DNA binding domain of ERG. Therefore, the resulting fusion protein deregulates a large number of genes by so far poorly defined mechanisms.
Oncogenesis In a transgenic mouse model expression of the EWS-ERG in lymphoid progenitors induced T-cell leukemia.
  
Entity Acute myeloid leukemia (AML)
Prognosis Several studies suggest a poorer prognosis for FUS-ERG gene fusion positive AML as compared to non-fused AML. Moreover, an ERG overexpression, not necessarily due to the FUS-ERG gene fusion, predicts an increased relapse risk and shorter survival in AML patients. However, the exact contribution of ERG overexpression to myeloid leukemiogenesis and progression is still unknown.
Hybrid/Mutated Gene In the FUS-ERG gene fusion, the FUS gene fuses with the carboxyl terminal of ERG containing the ETS DNA binding domain of ERG. Of note, in a single case, a gene fusion of ERG with the myeloid ELF-like factor 1 (ELF4) was detected.
Oncogenesis The FUS-ERG fusion protein helps in activating the oncogenic activity of transcription factors.
  
Entity Prostate cancer
Prognosis The body of literature is controversial about the prognostic relevance of ERG rearrangements in prostate cancer. Some studies reported an association of the ERG rearrangement with adverse clinical parameters (i.e. time to prostate cancer specific death and the development of hormone-refractory metastasis). On the other hand, some studies demonstrated an association of ERG rearrangement with parameters of more favourable outcome, such as lower Gleason score, stage, volume, better overall survival, or late biochemical recurrence. Interestingly, a subset of studies without any such association was reported as well.
 
Schematic displaying ERG rearrangement status (via FISH) in prostate cancer. The red-labelled centromeric and the green-labelled telomeric probes span the ERG locus on chromosomes 21. If a break-apart occurs, the green signal is either lost (ERG rearrangement through deletion) or translocated (ERG rearrangement through insertion). An ERG break-apart as determined by FISH accounts for a fusion of ERG mainly with TMPRSS2 but also with other 5' fusion partners such as SLC45A3, HERPUD1, or NDRG1. A: Both alleles with wild type (wt) ERG. B: One allele with ERG rearrangement through deletion (single red signal) and the other allele with wt ERG (yellow signal). C: One allele with ERG rearrangement through insertion (separated red and green signal) and the other allele with wt ERG (yellow signal).
Hybrid/Mutated Gene In approximately 50% of prostate cancers, the ERG gene is rearranged, i.e. fused to another gene. In case of a rearrangement, TMPRSS2 is the ERG 5' fusion partner in the vast majority of cases (app. 85%). Other known, but rarely occurring ERG fusion partners include NDRG1, SLC45A3, and HERPUD1. The ERG gene rearrangement either occurs due to a deletion, or an insertion.
Abnormal Protein An ERG gene rearrangement in prostate cancer mainly results in an androgen dependant ERG overexpression.
Oncogenesis In-vitro models complement that over expression of truncated ERG and various TMPRSS2-ERG isoforms increase cell migration and invasion. In-vivo recapitulation of ETS fusions by prostate specific expression of truncated ERG in mice resulted in the development of PIN but not carcinoma. Subsequent work on transgenic TMPRSS2-ERG mice develop PIN progressing to invasive cancer, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
  
Entity Acute lymphoblastic leukemia (ALL)
Prognosis Overexpression of ERG was shown to be a risk factor in adult T-ALL. ALL patients with ERG overexpression were four times more likely to fail long-term recurrence free survival, indicating inferior survival.
Oncogenesis Studies assessing ERG overexpression in ALL have shown that due to the involvement of ERG in T-cell development, it may have an oncogenic potential.
  
Entity Acute megakaryoblastic leukemia (AMKL)
Prognosis Even though ERG is highly considered to be oncogenic in AMKL, no prognostic relevance has been determined.
Oncogenesis ERG was found to be expressed megakaryoblastic leukemic cell lines and in primary leukemic cells from DS patients. Moreover, in mouse models, expression of ERG drove megakaryopoiesis and lead to a rapid development of aggressive leukemia.
  
Entity Alzheimer's disease (AD)
Note ERG has been linked to AD, due to an ERG protein overexpression as compared to control patients. This is further supported by experiments conducted on patients suffering from Down syndrome, who gradually develop AD-like symptoms, linked to ERG overexpression.
  
Entity Down syndrome (DS)
Note DS is associated with trisomy of the chromosome 21, where the ERG gene is located. The trisomy is considered to be responsible for an ERG overexpression. In a DS mouse model, an induced functional disomy of the ERG allele corrects some pathologic features of the disease, including myeloproliferation and progenitor cell expansion, suggesting a pathogenic effect of trisomy driven ERG overexpression.
  
Entity ERG involvement in endothelial development
Note ERG has been reported to regulate genes involved in chondrogenesis and angiogenesis and functions as a modulator of endothelial cell differentiation. In an in-vitro study, the decrease of the ERG protein follows a reduction in endothelial cell proliferation and vascular tube formation. In human umbilical vein endothelial cell lines, vascular endothelial growth factor (VEGF) was seen to significantly up-regulate ERG expression. Controversially, on the other hand, ERG expression was shown to inhibit responsiveness to the VEGF receptor in a Down Syndrome mouse model.
  
Entity ERG involvement in lymphoid development
Note ERG was reported to be expressed in during early T and B cell development, and to be down-regulated in later stages of B and T cell differentiation. In detail, the ERG protein modulates the maturation of lymphoid cells. Interestingly, ERG overexpression is associated with T-ALL.
  

Breakpoints

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945 MedulloblastomaID5065 rhab5004 rhabID5004 blad5001
bladID5001 colon5006 colonID5006 EmbryoRhabdomyoID5193

External links

Nomenclature
HGNC (Hugo)ERG   3446
Cards
AtlasERGID53ch21q22
Entrez_Gene (NCBI)ERG  2078  v-ets avian erythroblastosis virus E26 oncogene homolog
GeneCards (Weizmann)ERG
Ensembl (Hinxton)ENSG00000157554 [Gene_View]  chr21:39751950-40033704 [Contig_View]  ERG [Vega]
ICGC DataPortalENSG00000157554
AceView (NCBI)ERG
Genatlas (Paris)ERG
WikiGenes2078
SOURCE (Princeton)NM_001136154 NM_001136155 NM_001243428 NM_001243429 NM_001243432 NM_001243433 NM_001291391 NM_004449 NM_182918
Genomic and cartography
GoldenPath (UCSC)ERG  -  21q22.2   chr21:39751950-40033704 -  21q22.3   [Description]    (hg19-Feb_2009)
EnsemblERG - 21q22.3 [CytoView]
Mapping of homologs : NCBIERG [Mapview]
OMIM165080   
Gene and transcription
Genbank (Entrez)AA706319 AF015313 AK297807 AK300395 AK301277
RefSeq transcript (Entrez)NM_001136154 NM_001136155 NM_001243428 NM_001243429 NM_001243432 NM_001243433 NM_001291391 NM_004449 NM_182918
RefSeq genomic (Entrez)AC_000153 NC_000021 NC_018932 NG_029732 NT_011512 NW_001838708 NW_004929426
Consensus coding sequences : CCDS (NCBI)ERG
Cluster EST : UnigeneHs.473819 [ NCBI ]
CGAP (NCI)Hs.473819
Alternative Splicing : Fast-db (Paris)GSHG0019699
Alternative Splicing GalleryENSG00000157554
Gene ExpressionERG [ NCBI-GEO ]     ERG [ SEEK ]   ERG [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11308 (Uniprot)
NextProtP11308  [Medical]
With graphics : InterProP11308
Splice isoforms : SwissVarP11308 (Swissvar)
Domaine pattern : Prosite (Expaxy)ETS_DOMAIN_1 (PS00345)    ETS_DOMAIN_2 (PS00346)    ETS_DOMAIN_3 (PS50061)    PNT (PS51433)   
Domains : Interpro (EBI)Ets_dom    Pointed_dom    SAM/pointed    WHTH_DNA-bd_dom   
Related proteins : CluSTrP11308
Domain families : Pfam (Sanger)Ets (PF00178)    SAM_PNT (PF02198)   
Domain families : Pfam (NCBI)pfam00178    pfam02198   
Domain families : Smart (EMBL)ETS (SM00413)  SAM_PNT (SM00251)  
DMDM Disease mutations2078
Blocks (Seattle)P11308
PDB (SRS)1SXE    4IRG    4IRH    4IRI   
PDB (PDBSum)1SXE    4IRG    4IRH    4IRI   
PDB (IMB)1SXE    4IRG    4IRH    4IRI   
PDB (RSDB)1SXE    4IRG    4IRH    4IRI   
Human Protein AtlasENSG00000157554
Peptide AtlasP11308
HPRD01298
IPIIPI00005012   IPI00220990   IPI00549287   IPI00217544   IPI00788647   IPI00853428   IPI00910082   IPI00853570   IPI00797389   IPI00926377   IPI00974001   
Protein Interaction databases
DIP (DOE-UCLA)P11308
IntAct (EBI)P11308
FunCoupENSG00000157554
BioGRIDERG
IntegromeDBERG
STRING (EMBL)ERG
Ontologies - Pathways
QuickGOP11308
Ontology : AmiGOsequence-specific DNA binding RNA polymerase II transcription factor activity  DNA binding  signal transducer activity  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  signal transduction  multicellular organismal development  cell proliferation  cell differentiation  ribonucleoprotein complex  sequence-specific DNA binding  
Ontology : EGO-EBIsequence-specific DNA binding RNA polymerase II transcription factor activity  DNA binding  signal transducer activity  protein binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  signal transduction  multicellular organismal development  cell proliferation  cell differentiation  ribonucleoprotein complex  sequence-specific DNA binding  
Pathways : KEGGTranscriptional misregulation in cancer   
Protein Interaction DatabaseERG
Wikipedia pathwaysERG
Gene fusion - rearrangments
Rearrangement : COSMICTMPRSS2 [21q22.3]  -  ERG [21q22.2]
Rearrangement : TICdbEWSR1 [22q12.2]  -  ERG [2q36.1]
Rearrangement : TICdbFUS [16p11.2]  -  ERG [10q11.21]
Rearrangement : TICdbNDRG1 [8q24.22]  -  ERG [12q13.13]
Rearrangement : TICdbTMPRSS2 [21q22.3]  -  ERG []
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ERG
SNP (GeneSNP Utah)ERG
SNP : HGBaseERG
Genetic variants : HAPMAPERG
1000_GenomesERG 
ICGC programENSG00000157554 
Cancer Gene: CensusERG 
CONAN: Copy Number AnalysisERG 
Somatic Mutations in Cancer : COSMICERG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)21:39751950-40033704
Mutations and Diseases : HGMDERG
OMIM165080   
MedgenERG
GENETestsERG
Disease Genetic AssociationERG
Huge Navigator ERG [HugePedia]  ERG [HugeCancerGEM]
Genomic VariantsERG  ERG [DGVbeta]
Exome VariantERG
dbVarERG
ClinVarERG
snp3D : Map Gene to Disease2078
DGIdb (Curated mutations)ERG
DGIdb (Drug Gene Interaction db)ERG
General knowledge
Homologs : HomoloGeneERG
Homology/Alignments : Family Browser (UCSC)ERG
Phylogenetic Trees/Animal Genes : TreeFamERG
Chemical/Protein Interactions : CTD2078
Chemical/Pharm GKB GenePA27858
Clinical trialERG
Cancer Resource (Charite)ENSG00000157554
Other databases
Other databaseCancer Genetics
Probes
Litterature
PubMed227 Pubmed reference(s) in Entrez
CoreMineERG
GoPubMedERG
iHOPERG

Bibliography

New human erg isoforms generated by alternative splicing are transcriptional activators.
Duterque-Coquillaud M, Niel C, Plaza S, Stehelin D.
Oncogene. 1993 Jul;8(7):1865-73.
PMID 8510931
 
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.
Giovannini M, Biegel JA, Serra M, Wang JY, Wei YH, Nycum L, Emanuel BS, Evans GA.
J Clin Invest. 1994 Aug;94(2):489-96.
PMID 8040301
 
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y.
Blood. 1997 Aug 1;90(3):1192-9.
PMID 9242552
 
Selective expression of erg isoforms in human endothelial cells.
Hewett PW, Nishi K, Daft EL, Clifford Murray J.
Int J Biochem Cell Biol. 2001 Apr;33(4):347-55.
PMID 11312105
 
The role of ERG (ets related gene) in cartilage development.
Iwamoto M, Higuchi Y, Enomoto-Iwamoto M, Kurisu K, Koyama E, Yeh H, Rosenbloom J, Pacifici M.
Osteoarthritis Cartilage. 2001;9 Suppl A:S41-7.
PMID 11680687
 
Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation.
McLaughlin F, Ludbrook VJ, Cox J, von Carlowitz I, Brown S, Randi AM.
Blood. 2001 Dec 1;98(12):3332-9.
PMID 11719371
 
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR.
Cancer Cell. 2002 Mar;1(2):133-43.
PMID 12086872
 
Molecular biology of the Ets family of transcription factors.
Oikawa T, Yamada T.
Gene. 2003 Jan 16;303:11-34. (REVIEW)
PMID 12559563
 
Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes.
Baldus CD, Liyanarachchi S, Mrozek K, Auer H, Tanner SM, Guimond M, Ruppert AS, Mohamed N, Davuluri RV, Caligiuri MA, Bloomfield CD, de la Chapelle A.
Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3915-20. Epub 2004 Mar 8.
PMID 15007164
 
ETS transcription factors: possible targets for cancer therapy.
Oikawa T.
Cancer Sci. 2004 Aug;95(8):626-33. (REVIEW)
PMID 15298723
 
Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.
Owczarek CM, Portbury KJ, Hardy MP, O'Leary DA, Kudoh J, Shibuya K, Shimizu N, Kola I, Hertzog PJ.
Gene. 2004 Jan 7;324:65-77.
PMID 14693372
 
Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study.
Marcucci G, Baldus CD, Ruppert AS, Radmacher MD, Mrozek K, Whitman SP, Kolitz JE, Edwards CG, Vardiman JW, Powell BL, Baer MR, Moore JO, Perrotti D, Caligiuri MA, Carroll AJ, Larson RA, de la Chapelle A, Bloomfield CD.
J Clin Oncol. 2005 Dec 20;23(36):9234-42. Epub 2005 Nov 7.
PMID 16275934
 
The proto-oncogene ERG in megakaryoblastic leukemias.
Rainis L, Toki T, Pimanda JE, Rosenthal E, Machol K, Strehl S, Gottgens B, Ito E, Izraeli S.
Cancer Res. 2005 Sep 1;65(17):7596-602.
PMID 16140924
 
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM.
Science. 2005 Oct 28;310(5748):644-8.
PMID 16254181
 
Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression.
van Zelm MC, van der Burg M, de Ridder D, Barendregt BH, de Haas EF, Reinders MJ, Lankester AC, Revesz T, Staal FJ, van Dongen JJ.
J Immunol. 2005 Nov 1;175(9):5912-22.
PMID 16237084
 
At the crossroads: diverse roles of early thymocyte transcriptional regulators.
Anderson MK.
Immunol Rev. 2006 Feb;209:191-211. (REVIEW)
PMID 16448544
 
High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.
Baldus CD, Burmeister T, Martus P, Schwartz S, Gokbuget N, Bloomfield CD, Hoelzer D, Thiel E, Hofmann WK.
J Clin Oncol. 2006 Oct 10;24(29):4714-20. Epub 2006 Sep 5.
PMID 16954520
 
ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).
Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P.
Leuk Res. 2006 Aug;30(8):1037-42. Epub 2005 Nov 21.
PMID 16303180
 
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
Loughran SJ, Kruse EA, Hacking DF, de Graaf CA, Hyland CD, Willson TA, Henley KJ, Ellis S, Voss AK, Metcalf D, Hilton DJ, Alexander WS, Kile BT.
Nat Immunol. 2008 Jul;9(7):810-9. Epub 2008 May 25.
PMID 18500345
 
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
Nat Genet. 2009 May;41(5):619-24. Epub 2009 Apr 26.
PMID 19396168
 
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
Nat Genet. 2009 May;41(5):524-6. Epub 2009 Apr 26.
PMID 19396167
 
ERG is a megakaryocytic oncogene.
Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ.
Cancer Res. 2009 Jun 1;69(11):4665-73.
PMID 19487285
 
ETS gene fusions in prostate cancer: from discovery to daily clinical practice.
Tomlins SA, Bjartell A, Chinnaiyan AM, Jenster G, Nam RK, Rubin MA, Schalken JA.
Eur Urol. 2009 Aug;56(2):275-86. Epub 2009 Apr 24. (REVIEW)
PMID 19409690
 
Prostate cancer genes associated with TMPRSS2-ERG gene fusion and prognostic of biochemical recurrence in multiple cohorts.
Barwick BG, Abramovitz M, Kodani M, Moreno CS, Nam R, Tang W, Bouzyk M, Seth A, Leyland-Jones B.
Br J Cancer. 2010 Feb 2;102(3):570-6. Epub 2010 Jan 12.
PMID 20068566
 
Expression of the androgen-regulated fusion gene TMPRSS2-ERG does not predict response to endocrine treatment in hormone-naive, node-positive prostate cancer.
Boormans JL, Hermans KG, Made AC, van Leenders GJ, Wildhagen MF, Collette L, Schroder FH, Trapman J, Verhagen PC.
Eur Urol. 2010 May;57(5):830-5. Epub 2009 Aug 22.
PMID 19716227
 
The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia.
Coskun E, von der Heide EK, Schlee C, Kuhnl A, Gokbuget N, Hoelzer D, Hofmann WK, Thiel E, Baldus CD.
Leuk Res. 2010 Jun 4. [Epub ahead of print]
PMID 20570349
 
Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome.
De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, Baldo C, Vanes L, Dagna-Bricarelli F, Hoischen A, Veltman J, Fisher EM, Tybulewicz VL, Nizetic D.
Oncogene. 2010 Nov 18;29(46):6102-14. Epub 2010 Aug 9.
PMID 20697343
 
BAALC and ERG expression in acute myeloid leukemia with normal karyotype: impact on prognosis.
Eid MA, Attia M, Abdou S, El-Shazly SF, Elahwal L, Farrag W, Mahmoud L.
Int J Lab Hematol. 2010 Apr;32(2):197-205. Epub 2009 Jun 23.
PMID 19555438
 
ERG rearrangement is present in a subset of transition zone prostatic tumors.
Falzarano SM, Navas M, Simmerman K, Klein EA, Rubin MA, Zhou M, Magi-Galluzzi C.
Mod Pathol. 2010 Nov;23(11):1499-506. Epub 2010 Aug 6.
PMID 20693982
 
Identification of a cell of origin for human prostate cancer.
Goldstein AS, Huang J, Guo C, Garraway IP, Witte ON.
Science. 2010 Jul 30;329(5991):568-71.
PMID 20671189
 
FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells.
Gupta S, Iljin K, Sara H, Mpindi JP, Mirtti T, Vainio P, Rantala J, Alanen K, Nees M, Kallioniemi O.
Cancer Res. 2010 Sep 1;70(17):6735-45. Epub 2010 Aug 16.
PMID 20713528
 
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
Haffner MC, Aryee MJ, Toubaji A, Esopi DM, Albadine R, Gurel B, Isaacs WB, Bova GS, Liu W, Xu J, Meeker AK, Netto G, De Marzo AM, Nelson WG, Yegnasubramanian S.
Nat Genet. 2010 Aug;42(8):668-75. Epub 2010 Jul 4.
PMID 20601956
 
ETS-related gene ERG expression in AML patients is significantly associated with NPM1 mutation status.
Hamalainen M, Juvonen V, Haikio S, Lakkala T, Johansson J, Pelliniemi TT, Salmi TT, Remes K, Kairisto V.
Eur J Haematol. 2010 Oct;85(4):361-2. doi: 10.1111/j.1600-0609.2010.01483.x. Epub 2010 Jul 13.
PMID 20546020
 
ETS gene aberrations in atypical cribriform lesions of the prostate: Implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasia.
Han B, Suleman K, Wang L, Siddiqui J, Sercia L, Magi-Galluzzi C, Palanisamy N, Chinnaiyan AM, Zhou M, Shah RB.
Am J Surg Pathol. 2010 Apr;34(4):478-85.
PMID 20220513
 
Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis.
Heo SH, Choi YJ, Ryoo HM, Cho JY.
J Cell Physiol. 2010 Sep;224(3):734-42.
PMID 20432469
 
Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma.
Jinawath N, Morsberger L, Norris-Kirby A, Williams LM, Yonescu R, Argani P, Griffin CA, Murphy KM.
Cancer Genet Cytogenet. 2010 Aug;201(1):42-7.
PMID 20633768
 
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.
Kunderfranco P, Mello-Grand M, Cangemi R, Pellini S, Mensah A, Albertini V, Malek A, Chiorino G, Catapano CV, Carbone GM.
PLoS One. 2010 May 10;5(5):e10547.
PMID 20479932
 
VE-statin/egfl7 expression in endothelial cells is regulated by a distal enhancer and a proximal promoter under the direct control of Erg and GATA-2.
Le Bras A, Samson C, Trentini M, Caetano B, Lelievre E, Mattot V, Beermann F, Soncin F.
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Written08-2006Liat Rainis-Ganon, Shai Izraeli
Head, Research section, Pediatric Hemato-Oncology, Cancer Research Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel 52621
Updated11-2010Roopika Menon, Martin Braun, Sven Perner
Institute of Pathology, University Hospital Tuebingen, Liebermeisterstr. 8, D-72076 Tuebingen, Germany

Citation

This paper should be referenced as such :
Menon, R ; Braun, M ; Perner, S
ERG (v-ets erythroblastosis virus E26 oncogene like (avian))
Atlas Genet Cytogenet Oncol Haematol. 2011;15(7):547-553.
Free online version   Free pdf version   [Bibliographic record ]
History of this paper:
Menon, R ; Braun, M ; Perner, S. ERG (v-ets erythroblastosis virus E26 oncogene like (avian)). Atlas Genet Cytogenet Oncol Haematol. 2011;15(7):547-553.
http://documents.irevues.inist.fr/bitstream/handle/2042/45991/11-2010-ERGID53ch21q22.pdf
URL : http://AtlasGeneticsOncology.org/Genes/ERGID53ch21q22.html

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