FNBP1 (Formin Binding Protein 17)
2001-03-01 Uta Fuchs , Arndt Borkhardt AffiliationChildrens University Hospital Giessen, Hematology & Oncology, Feulgenstr. 12, 35392 Giessen, Germany
DNA/RNA
Description
at least 2042 bp
Transcription
open reading frame of 679 amino acids
Proteins
FCH-domain: amino terminus; cdc15 homology region: aa 96-290; Rho-binding domain: aa 475-537; SH3-domain: aa 612-669
Description
679 amino acids, 75 kDa
Expression
strong expression in epithelial cells from the respiratory system, gastrointestinal tract, urinary, and reproductive system
Localisation
exclusively cytoplasmatic
Function
interacts with Sorting nexin 2 (SNX2) in vivo and in vitro
Mutations
Germinal
unknown
Somatic
unknown
Implicated in
Entity name
Prognosis
poor
Hybrid gene
5 MLL - 3 FBP17
Fusion protein
MLL/FBP17
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11438682 | 2001 | The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. | Fuchs U et al |
Other Information
Locus ID:
NCBI: 23048
MIM: 606191
HGNC: 17069
Ensembl: ENSG00000187239
Variants:
dbSNP: 23048
ClinVar: 23048
TCGA: ENSG00000187239
COSMIC: FNBP1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Vesicle-mediated transport | REACTOME | R-HSA-5653656 |
| Membrane Trafficking | REACTOME | R-HSA-199991 |
| Clathrin-mediated endocytosis | REACTOME | R-HSA-8856828 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37566043 | 2023 | FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling. | 0 |
| 37566043 | 2023 | FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling. | 0 |
| 34998385 | 2022 | Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. | 5 |
| 35134126 | 2022 | Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion. | 2 |
| 34998385 | 2022 | Membrane tension sensing molecule-FNBP1 is a prognostic biomarker related to immune infiltration in BRCA, LUAD and STAD. | 5 |
| 35134126 | 2022 | Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion. | 2 |
| 34202606 | 2021 | Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells. | 4 |
| 34202606 | 2021 | Sp1-Induced FNBP1 Drives Rigorous 3D Cell Motility in EMT-Type Gastric Cancer Cells. | 4 |
| 32665637 | 2020 | High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas. | 5 |
| 32665637 | 2020 | High formin binding protein 17 (FBP17) expression indicates poor differentiation and invasiveness of ductal carcinomas. | 5 |
| 31862885 | 2019 | An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. | 27 |
| 31862885 | 2019 | An Abl-FBP17 mechanosensing system couples local plasma membrane curvature and stress fiber remodeling during mechanoadaptation. | 27 |
| 29651632 | 2018 | High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. | 12 |
| 30061681 | 2018 | FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. | 48 |
| 29651632 | 2018 | High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. | 12 |
Citation
Uta Fuchs ; Arndt Borkhardt
FNBP1 (Formin Binding Protein 17)
Atlas Genet Cytogenet Oncol Haematol. 2001-03-01
Online version: http://atlasgeneticsoncology.org/gene/353/fnbp1
