FGFR1OP (FGFR1 oncogene partner)

Alias (NCBI)	FOP (Fibroblast Growth Factor Receptor 1 Oncogene Partner)
LocusID (NCBI)	11116
Atlas_Id	140
Location	6q27  [Link to chromosome band 6q27]
Location_base_pair	Starts at and ends at bp from pter
	FOP (6q27) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.

Description	399 amino acids; predicted molecular mass: 44.3 kDa; Hydrophobic protein containing in its N- and C-termini several regions folding in a-helices with leucine-rich repeats with the consensus sequence L-X2-L-X3-5-L-X3-5-L, in one-third of which the leucine is substituted by either a valine or an isoleucine
Expression	ubiquitous expression
Localisation	cell cytoplasm
Function	unknown

Note
Entity	t(6;8)(q27; p12) myeloproliferative disorder --> FGFR1OP - FGFR1 ; stem-cell myeloproliferative disorder associated with the 8p12 chromosomal translocations with fusions to the catalytic domain of FGFR1
Disease	stem-cell myeloproliferative disorder characterized by myeloid hyperplasia, T -cell lymphoblastic leukemia/lymphoma and peripheral blood eosinophilia, and it generally progresses to acute myeloid leukemia; specific to the 8p12 chromosomal region.
Prognosis	very poor (median survival: 12 mths)
Cytogenetics	additional abnormalities: 2q+ and +21
Hybrid/Mutated Gene	5' FOP - 3' FGFR1; localisation: der(6)
Abnormal Protein	N-term leucine-rich region from FOP fused to the catalytic domain of FGFR1 (FGFR1 intracellular region minus the major part of the juxtamembrane domain)
Oncogenesis	constitutive kinase activity of FGFR1 through constitutive activation of FGFR1 signal transduction pathways via putative constitutive dimerization capability mediated by the FOP N-term LRR sequences

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