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FOXP3 (forkhead box P3)

Identity

Other namesAIID
DIETER
IPEX
JM2
MGC141961
MGC141963
PIDX
SCURFIN
XPID
HGNC (Hugo) FOXP3
LocusID (NCBI) 50943
Location Xp11.23
Location_base_pair Starts at 49106897 and ends at 49121288 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order Xp telomere 3'- FOXP3 -5' centromere
 
  The location and orientation of FOXP3 gene on X chromosome. The X-linked gene FOXP3 is a member of the forkhead-box/winged-helix transcription factor family. It was identified during position cloning of Scurfin, a gene responsible for X-linked autoimmune diseases in mice and humans (Chatila et al., 2000; Brunkow et al., 2001; Bennett et al., 2001; Wildin et al., 2001).
Note ChrX 48994354-49008232 bps

DNA/RNA

Note Some Gene Database only showed 11 coding exons and the first exon is not contained.
 
  Figure a: Schematic diagram of the FOXP3 gene and protein. ZF: zinc finger domain, LZ: leucine zipper domain, and FKH fork-head domain.
Figure b: Alternatively spliced transcript variants encoding different isoforms have been identified. The two isoforms 1 and 2 is shown in the deletion of exon 3 and exon 3 with 5' part of exon 4, respectively. Other splice variant lacking both exons 3 and 8 was also reported (Smith et al., 2006).
Description 12 exons; the first exon, 5' part of exon 2 and 3' part of exon 12 are non-coding.
Transcription 1869 bps mRNA; transcribed in a centromeric to telomeric orientation. Alternative splicing: we have identified two isoforms in both normal breast and prostate cell lines and tissues, but thirteen isoforms were found in breast, prostate, and pancreas cell lines.
Pseudogene None

Protein

Note None
Description The FOXP3 protein is 431-amino acid long and its molecular weight is 47.25 kilo Daltons. It contains four potential functional domains including the repressor, ZF, LZ and fork-head (FKH) domains. The repressor domain is localized to the N-terminal region of FOXP3 and is required to repress NFAT-mediated transcriptional activity (Bettelli et al., 2005; Lopes et al., 2006; Wu et al., 2006). The mutant LZ domain impairs both dimerization and suppressive function of FoxP3 in T cells (Chae et al., 2006). The FKH domain is critical for both DNA binding and nuclear localization (Ziegler 2006). The FKH domain is the most frequent target in immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX) patients.
Expression FOXP3 locus is transcribed in the regulatory T cell. We used the Rag2 (-/-) and the Rag2 (-/-) mice with the Scurfy (sf) mutation (FoxP3 (sf/Y) or FoxP3 (sf/sf)) to evaluate FoxP3 expression outside of the lymphoid system. Immunohistochemistry and real-time PCR revealed FoxP3 expression in breast epithelial cells, lung respiratory epithelial cells, and prostate epithelial cells, although not in liver, heart, and intestine (Chen et al., 2008). Using mice with a green fluorescence protein open reading frame knocked into the 3' untranslated region of the FoxP3 locus, we showed that the locus is transcribed broadly in epithelial cells of multiple organs (Chen et al., 2008). In human, FOXP3 is expressed in normal human breast epithelial cells but is silenced in most human breast cancers (Zuo et al., 2007b).
Localisation Predominately nuclear
Function Foxp3 is a member of the forkhead/winged-helix family of transcriptional regulators and functions as the master regulator in the development and function of regulatory T (Treg) cells (Fontenot et al., 2003; Hori et al., 2003; Khattri et al., 2003). Nevertheless, there is still a controversy as to whether defect Treg alone explains the lethal autoimmune diseases observed in the mutant mouse and man (Chang et al., 2005; Godfrey et al., 1991). Moreover, FOXP3 as the first X-linked tumor suppressor directly targets two critical oncogenes HER2/ErbB2 and SKP2 and represses their transcription activity to inhibit cell growth in breast cancer (Zuo et al., 2007a; Zuo et al., 2007b).
Homology FOXP1, FOXP2, and FOXP3 all have the FKH domain and may interact with cytokine gene transactivators NFkappaB and NFAT to regulate several cytokine gene transcription in T cells (Bettelli et al., 2005; Tone et al., 2008; Wu et al., 2006). However, their functional roles are alterative in different T cells.

Mutations

Note The somatic mutations but not germline mutations in breast cancer patients.
 
  Somatic mutation of the FOXP3 gene in breast cancer samples: summary of sequencing data from 65 cases, including 50 formalin-fixed samples and 15 frozen samples. Genomic DNA was isolated from matched normal and cancerous tissues from the same patients and amplified with primers for individual exons and intron-exon boundary regions. Somatic mutations were identified by comparing sequences from normal and cancerous samples from the same patients. The data are from either bulk sequencing of PCR products or from the sequencing of 5-10 clones from PCR products. Only those mutations that were observed in multiple clones were scored. Mutations identified from 50 cases of formalin-fixed samples are marked in black, while those identified from 15 cases of frozen tissue samples are marked in red.
Germinal In mice, a Foxp3 frameshift mutation in the forkhead domain results in lethality in hemizygous males 16 to 25 days after birth (Brunkow et al., 2001). The mutation in some human IPEX patients is analogous as they cause frameshift and early termination of translation (Chatila, 2000; Brunkow, 2001; Bennett, 2001; Wildin, 2001).
Somatic In breast cancer patients, a total of 27 somatic mutations in all 11 coding exons and intron-exon boundary regions have been identified in 36% of 65 patients by PCR (Zuo et al., 2007b). In these mutations, there are 18 nonsynonymous mutations, 3 synonymous mutations and 6 mutations in the intron-exon junction 12 (Zuo et al. 2007b). Interestingly, the mutations are not randomly distributed in FOXP3 gene and the overwhelming majority of the mutations were either in the functional domains or within intron 11 which can affect the forkhead domain sequence (Zuo et al. 2007b).

Implicated in

Entity Breast cancer
Note None
Disease In majority of the mammary cancers, Foxp3 allele was inactivated and HER-2/ErbB2 and SKP2 are overexpressed and repressed the HER-2/ErbB2 and SKP2 promoters. Deletion, functionally significant somatic mutations, and down-regulation of the FOXP3 gene are commonly found in human breast cancer samples and correlated significantly with HER-2/ErbB2 over-expression, regardless of the status of HER-2 amplification. FOXP3 is an X-linked breast cancer suppressor gene and an important regulator of the HER-2/ErbB2 and SKP2 oncogenes in breast cancer development.
Prognosis None
Cytogenetics In fluorescence in situ hybridization (FISH) analysis, the FOXP3 gene is frequently deleted in the breast cancer samples. Out of 223 informative samples, we observed 28 cases (12.6%) with FXOP3 deletion. FOXP3 is likely within the minimal region of deletion in the Xp11 region studied. Although all deletions were heterozygous, the FOXP3 protein was undetectable in 26 out of 28 cases. Thus, it appears that for the majority of the breast cancer samples, LOH alone was sufficient to inactivate the locus, perhaps due to X-chromosomal inactivation. The two cases with both deletion and FOXP3 expression had X polysomy with three and four X chromosomes, respectively.
 
X-chromosomal deletion pattern in breast cancer. TMA samples were probed with 3 markers for X-chromosome as marked. The deletion of each probe was scored independently and summarized in the colour bars, each bar representing one case. Note that the FOXP3 locus encompasses the minimal deletion in the 10MB area of the X-chromosome. A typical FISH for the CEPX (green) and FOXP3 (orange) probes is shown.
Hybrid/Mutated Gene None
Abnormal Protein None
Oncogenesis Mice with the Foxp3 heterozygous mutation spontaneously developed mammary cancer at a high rate (Zuo et al., 2007b). Foxp3 mutation have a comparably higher incidence of human mammary cancer and is likely responsible for the increased rate of breast cancer. Our analysis of human breast cancer samples provides strong support for an important role for the FOXP3 gene in the development of breast cancer (Zuo et al., 2007a; Zuo et al., 2007b). First, FOXP3 is likely the minimal region of deletion in breast cancer. Second, a high proportion of somatic mutations in the FOXP3 gene are identified in breast cancer and most of the mutations resulted in the non-conservative replacement of amino acids, and the deletions and mutations of the FOXP3 locus corresponded to increased HER-2 and SKP2 levels. Third, approximate 80% breast cancers have a down-regulation of FOXP3 in tumor tissues compared to normal breast tissues. These data indicated that FOXP3 is an X-Linked mammary tumor suppressor gene.
  

Breakpoints

 
  Ingenuity Pathway analysis indicated that FoxP3-regulated genes belong to multiple cellular pathways related to the process of cancer development. Most of which are not directly related to FOXP3-mediated repression of ErbB2 (Zuo et al., 2007b). Interestingly, when we used the GeneGo MetaCore knowledgebase to analyze genes that related to ErbB2 signaling pathway, we found that FOXP3 down-regulated 10 genes in this pathway. With the notable exception of b-Myb and c-Myb, the down-regulation is not likely related to FoxP3-mediated ErbB2 repression, as they are not known transcriptional targets of ErbB2. Thus, FOXP3 can suppress ErbB2 signaling and tumor growth by mechanisms other than ErbB2 expression. These data provide a plausible explanation for the tumor suppressor activity of FOXP3 in breast cancer cell lines that do not substantially overexpress HER-2. We also demonstrated that downregulation of SKP2 was critical for FOXP3-mediated growth inhibition in breast cancer cells that do not overexpress ERBB2/HER2 (Zuo et al., 2007a). Our data provide genetic, biochemical, and functional evidence that FOXP3 is a novel transcriptional repressor for the oncogenes HER2/ErbB2 and SKP2 (Zuo et al., 2007b; Zuo et al., 2007a).
Note None

To be noted

None

External links

Nomenclature
HGNC (Hugo)FOXP3   6106
Cards
AtlasFOXP3ID44129chXp11
Entrez_Gene (NCBI)FOXP3  50943  forkhead box P3
GeneCards (Weizmann)FOXP3
Ensembl (Hinxton)ENSG00000049768 [Gene_View]  chrX:49106897-49121288 [Contig_View]  FOXP3 [Vega]
ICGC DataPortalENSG00000049768
AceView (NCBI)FOXP3
Genatlas (Paris)FOXP3
WikiGenes50943
SOURCE (Princeton)NM_001114377 NM_014009
Genomic and cartography
GoldenPath (UCSC)FOXP3  -  Xp11.23   chrX:49106897-49121288 -  Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblFOXP3 - Xp11.23 [CytoView]
Mapping of homologs : NCBIFOXP3 [Mapview]
OMIM222100   300292   304790   
Gene and transcription
Genbank (Entrez)AF277993 AJ005891 AK292052 AK299988 BC111853
RefSeq transcript (Entrez)NM_001114377 NM_014009
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_007392 NT_079573 NW_001842363 NW_004929439
Consensus coding sequences : CCDS (NCBI)FOXP3
Cluster EST : UnigeneHs.247700 [ NCBI ]
CGAP (NCI)Hs.247700
Alternative Splicing : Fast-db (Paris)GSHG0032095
Alternative Splicing GalleryENSG00000049768
Gene ExpressionFOXP3 [ NCBI-GEO ]     FOXP3 [ SEEK ]   FOXP3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZS1 (Uniprot)
NextProtQ9BZS1  [Medical]
With graphics : InterProQ9BZS1
Splice isoforms : SwissVarQ9BZS1 (Swissvar)
Domaine pattern : Prosite (Expaxy)FORK_HEAD_2 (PS00658)    FORK_HEAD_3 (PS50039)    ZINC_FINGER_C2H2_1 (PS00028)   
Domains : Interpro (EBI)TF_fork_head    TF_fork_head_CS    WHTH_DNA-bd_dom    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrQ9BZS1
Domain families : Pfam (Sanger)Fork_head (PF00250)   
Domain families : Pfam (NCBI)pfam00250   
Domain families : Smart (EMBL)FH (SM00339)  ZnF_C2H2 (SM00355)  
DMDM Disease mutations50943
Blocks (Seattle)Q9BZS1
PDB (SRS)3QRF   
PDB (PDBSum)3QRF   
PDB (IMB)3QRF   
PDB (RSDB)3QRF   
Human Protein AtlasENSG00000049768
Peptide AtlasQ9BZS1
HPRD02242
IPIIPI00328094   IPI00604500   IPI00644203   IPI00922760   IPI00923585   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZS1
IntAct (EBI)Q9BZS1
FunCoupENSG00000049768
BioGRIDFOXP3
IntegromeDBFOXP3
STRING (EMBL)FOXP3
Ontologies - Pathways
QuickGOQ9BZS1
Ontology : AmiGOB cell homeostasis  cytokine production  myeloid cell homeostasis  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  T cell mediated immunity  tolerance induction to self antigen  positive regulation of T cell anergy  negative regulation of chronic inflammatory response  negative regulation of T cell cytokine production  positive regulation of peripheral T cell tolerance induction  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  chromatin remodeling  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  negative regulation of cell proliferation  response to virus  negative regulation of histone deacetylation  negative regulation of NF-kappaB transcription factor activity  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  negative regulation of interleukin-2 production  negative regulation of interleukin-4 production  negative regulation of interleukin-5 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-4 production  negative regulation of CREB transcription factor activity  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  positive regulation of transforming growth factor beta1 production  positive regulation of immature T cell proliferation in thymus  histone acetyltransferase binding  positive regulation of histone acetylation  negative regulation of histone acetylation  negative regulation of cytokine biosynthetic process  T cell activation  negative regulation of T cell proliferation  protein homodimerization activity  histone deacetylase binding  T cell homeostasis  protein complex  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  negative regulation of interferon-gamma biosynthetic process  negative regulation of interleukin-2 biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of activated T cell proliferation  metal ion binding  negative regulation of isotype switching to IgE isotypes  regulation of isotype switching to IgG isotypes  negative regulation of cytokine secretion  negative regulation of immune response  T cell receptor signaling pathway  NF-kappaB binding  NFAT protein binding  
Ontology : EGO-EBIB cell homeostasis  cytokine production  myeloid cell homeostasis  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  T cell mediated immunity  tolerance induction to self antigen  positive regulation of T cell anergy  negative regulation of chronic inflammatory response  negative regulation of T cell cytokine production  positive regulation of peripheral T cell tolerance induction  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  transcription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  cytoplasm  chromatin remodeling  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  negative regulation of cell proliferation  response to virus  negative regulation of histone deacetylation  negative regulation of NF-kappaB transcription factor activity  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  negative regulation of interleukin-2 production  negative regulation of interleukin-4 production  negative regulation of interleukin-5 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-4 production  negative regulation of CREB transcription factor activity  positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  positive regulation of transforming growth factor beta1 production  positive regulation of immature T cell proliferation in thymus  histone acetyltransferase binding  positive regulation of histone acetylation  negative regulation of histone acetylation  negative regulation of cytokine biosynthetic process  T cell activation  negative regulation of T cell proliferation  protein homodimerization activity  histone deacetylase binding  T cell homeostasis  protein complex  negative regulation of sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding  negative regulation of interferon-gamma biosynthetic process  negative regulation of interleukin-2 biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of activated T cell proliferation  metal ion binding  negative regulation of isotype switching to IgE isotypes  regulation of isotype switching to IgG isotypes  negative regulation of cytokine secretion  negative regulation of immune response  T cell receptor signaling pathway  NF-kappaB binding  NFAT protein binding  
Pathways : KEGGInflammatory bowel disease (IBD)   
Protein Interaction DatabaseFOXP3
Wikipedia pathwaysFOXP3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FOXP3
SNP (GeneSNP Utah)FOXP3
SNP : HGBaseFOXP3
Genetic variants : HAPMAPFOXP3
1000_GenomesFOXP3 
ICGC programENSG00000049768 
CONAN: Copy Number AnalysisFOXP3 
Somatic Mutations in Cancer : COSMICFOXP3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
DECIPHER (Syndromes)X:49106897-49121288
Mutations and Diseases : HGMDFOXP3
OMIM222100    300292    304790   
MedgenFOXP3
GENETestsFOXP3
Disease Genetic AssociationFOXP3
Huge Navigator FOXP3 [HugePedia]  FOXP3 [HugeCancerGEM]
Genomic VariantsFOXP3  FOXP3 [DGVbeta]
Exome VariantFOXP3
dbVarFOXP3
ClinVarFOXP3
snp3D : Map Gene to Disease50943
General knowledge
Homologs : HomoloGeneFOXP3
Homology/Alignments : Family Browser (UCSC)FOXP3
Phylogenetic Trees/Animal Genes : TreeFamFOXP3
Chemical/Protein Interactions : CTD50943
Chemical/Pharm GKB GenePA201094
Clinical trialFOXP3
Cancer Resource (Charite)ENSG00000049768
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineFOXP3
GoPubMedFOXP3
iHOPFOXP3

Bibliography

Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic education.
Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB.
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5528-32.
PMID 2062835
 
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.
Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, Bowcock AM.
J Clin Invest. 2000 Dec;106(12):R75-81.
PMID 11120765
 
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD.
Nat Genet. 2001 Jan;27(1):20-1.
PMID 11137993
 
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F.
Nat Genet. 2001 Jan;27(1):68-73.
PMID 11138001
 
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy.
Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow ME.
Nat Genet. 2001 Jan;27(1):18-20.
PMID 11137992
 
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.
Fontenot JD, Gavin MA, Rudensky AY.
Nat Immunol. 2003 Apr;4(4):330-6.
PMID 12612578
 
Control of regulatory T cell development by the transcription factor Foxp3.
Hori S, Nomura T, Sakaguchi S.
Science. 2003 Feb 14;299(5609):1057-61.
PMID 12522256
 
An essential role for Scurfin in CD4+CD25+ T regulatory cells.
Khattri R, Cox T, Yasayko SA, Ramsdell F.
Nat Immunol. 2003 Apr;4(4):337-42.
PMID 12612581
 
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.
Chang X, Gao JX, Jiang Q, Wen J, Seifers N, Su L, Godfrey VL, Zuo T, Zheng P, Liu Y.
J Exp Med. 2005 Oct 17;202(8):1141-51.
PMID 16230479
 
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.
Bettelli E, Dastrange M, Oukka M.
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5138-43.
PMID 15790681
 
The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
Chae WJ, Henegariu O, Lee SK, Bothwell AL.
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9631-6.
PMID 16769892
 
Analysis of FOXP3 reveals multiple domains required for its function as a transcriptional repressor.
Lopes JE, Torgerson TR, Schubert LA, Anover SD, Ocheltree EL, Ochs HD, Ziegler SF.
J Immunol. 2006 Sep 1;177(5):3133-42.
PMID 16920951
 
Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK.
Immunology 2006 Oct;119(2):203-11.
PMID 17005002
 
FOXP3 controls regulatory T cell function through cooperation with NFAT.
Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A.
Cell. 2006 Jul 28;126(2):375-87.
PMID 16873067
 
FOXP3: of mice and men.
Ziegler SF.
Annu Rev Immunol. 2006;24:209-26. (Review)
PMID 16551248
 
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.
J Clin Invest. 2007 Dec;117(12):3765-73.
Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y.
PMID 18008005
 
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Zuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y.
Cell. 2007 Jun 29;129(7):1275-86.
PMID 17570480
 
Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells.
Chen GY, Chen C, Wang L, Chang X, Zheng P, Liu Y.
J Immunol. 2008 Apr 15;180(8):5163-6.
PMID 18390696
 
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer.
Tone Y, Furuuchi K, Kojima Y, Tykocinski ML, Greene MI, Tone M.
Nat Immunol. 2008 Feb;9(2):194-202.
PMID 18157133
 
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Contributor(s)

Written06-2008Yang Liu, Lizhong Wang
Division of Immunotherapy, Department of Surgery Co-leader of Cancer Immunology Program, UMCCC Program of Molecular Mechanism of Diseases University of Michigan BSRB 2059, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA

Citation

This paper should be referenced as such :
Liu, Y ; Wang, L
FOXP3 (forkhead box P3)
Atlas Genet Cytogenet Oncol Haematol. 2009;13(5):343-347.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/FOXP3ID44129chXp11.html

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