AADAC (arylacetamide deacetylase)

2003-06-01  

Identity

HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
CES5A1,DAC

Other Information

Locus ID:

NCBI: 13
MIM: 600338
HGNC: 17
Ensembl: ENSG00000114771

Variants:

dbSNP: 13
ClinVar: 13
TCGA: ENSG00000114771
COSMIC: AADAC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114771ENST00000232892P22760
ENSG00000114771ENST00000488869C9K0E9

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218562912011Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine.23
103188291999Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase.14
264440752016Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort.14
235423472013Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production.11
224159312012A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity.6
193430462009Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.3
241257612014N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity.2
292536012018Association of the AADAC gene and Tourette syndrome in a Han Chinese cohort.2
286066032017Identification of enzymes responsible for nitrazepam metabolism and toxicity in human.1

Citation

Dessen P

AADAC (arylacetamide deacetylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/532/aadac