Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ACAT1 (acetyl-CoA acetyltransferase 1)

Identity

Alias (NCBI)ACAT
MAT
T2
THIL
HGNC (Hugo) ACAT1
HGNC Alias symbTHIL
HGNC Alias nameacetoacetyl Coenzyme A thiolase
HGNC Previous nameACAT
HGNC Previous nameacetyl-Coenzyme A acetyltransferase 1
LocusID (NCBI) 38
Atlas_Id 50049
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 108121567 and ends at 108147601 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACAT1 (11q22.3) / VPRBP (3p21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ACAT1   93
Cards
Entrez_Gene (NCBI)ACAT1    acetyl-CoA acetyltransferase 1
AliasesACAT; MAT; T2; THIL
GeneCards (Weizmann)ACAT1
Ensembl hg19 (Hinxton)ENSG00000075239 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075239 [Gene_View]  ENSG00000075239 [Sequence]  chr11:108121567-108147601 [Contig_View]  ACAT1 [Vega]
ICGC DataPortalENSG00000075239
TCGA cBioPortalACAT1
AceView (NCBI)ACAT1
Genatlas (Paris)ACAT1
SOURCE (Princeton)ACAT1
Genetics Home Reference (NIH)ACAT1
Genomic and cartography
GoldenPath hg38 (UCSC)ACAT1  -     chr11:108121567-108147601 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ACAT1  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathACAT1 - 11q22.3 [CytoView hg19]  ACAT1 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000075239
Genome Data Viewer NCBIACAT1 [Mapview hg19]  
OMIM203750   607809   
Gene and transcription
Genbank (Entrez)AF086561 AK312574 AW081574 BC010942 BC063853
RefSeq transcript (Entrez)NM_000019 NM_001386677 NM_001386678 NM_001386679 NM_001386681 NM_001386682 NM_001386685 NM_001386686 NM_001386687 NM_001386688 NM_001386689 NM_001386690 NM_001386691
Consensus coding sequences : CCDS (NCBI)ACAT1
Gene ExpressionACAT1 [ NCBI-GEO ]   ACAT1 [ EBI - ARRAY_EXPRESS ]   ACAT1 [ SEEK ]   ACAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)ACAT1 [ Firebrowse - Broad ]
GenevisibleExpression of ACAT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)38
GTEX Portal (Tissue expression)ACAT1
Human Protein AtlasENSG00000075239-ACAT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24752   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24752  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24752
PhosPhoSitePlusP24752
Domaine pattern : Prosite (Expaxy)THIOLASE_1 (PS00098)    THIOLASE_2 (PS00737)    THIOLASE_3 (PS00099)   
Domains : Interpro (EBI)Thiolase    Thiolase-like    Thiolase_acyl_enz_int_AS    Thiolase_AS    Thiolase_C    Thiolase_CS    Thiolase_N   
Domain families : Pfam (Sanger)Thiolase_C (PF02803)    Thiolase_N (PF00108)   
Domain families : Pfam (NCBI)pfam02803    pfam00108   
Conserved Domain (NCBI)ACAT1
PDB (RSDB)2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
PDB Europe2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
PDB (PDBSum)2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
PDB (IMB)2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
Structural Biology KnowledgeBase2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
SCOP (Structural Classification of Proteins)2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
CATH (Classification of proteins structures)2F2S    2IB7    2IB8    2IB9    2IBU    2IBW    2IBY   
SuperfamilyP24752
AlphaFold pdb e-kbP24752   
Human Protein Atlas [tissue]ENSG00000075239-ACAT1 [tissue]
HPRD01946
Protein Interaction databases
DIP (DOE-UCLA)P24752
IntAct (EBI)P24752
BioGRIDACAT1
STRING (EMBL)ACAT1
ZODIACACAT1
Ontologies - Pathways
QuickGOP24752
Ontology : AmiGOliver development  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  mitochondrion  mitochondrion  mitochondrial matrix  acetyl-CoA biosynthetic process  isoleucine catabolic process  isoleucine catabolic process  fatty acid beta-oxidation  fatty acid beta-oxidation  brain development  branched-chain amino acid catabolic process  response to hormone  response to organic cyclic compound  coenzyme A metabolic process  coenzyme A biosynthetic process  C-acetyltransferase activity  enzyme binding  potassium ion binding  cholesterol esterification  response to starvation  identical protein binding  acetyl-CoA catabolic process  ketone body biosynthetic process  ketone body catabolic process  ketone body catabolic process  adipose tissue development  extracellular exosome  metanephric proximal convoluted tubule development  coenzyme A binding  ketone body metabolic process  propionyl-CoA biosynthetic process  
Ontology : EGO-EBIliver development  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  acetyl-CoA C-acetyltransferase activity  mitochondrion  mitochondrion  mitochondrial matrix  acetyl-CoA biosynthetic process  isoleucine catabolic process  isoleucine catabolic process  fatty acid beta-oxidation  fatty acid beta-oxidation  brain development  branched-chain amino acid catabolic process  response to hormone  response to organic cyclic compound  coenzyme A metabolic process  coenzyme A biosynthetic process  C-acetyltransferase activity  enzyme binding  potassium ion binding  cholesterol esterification  response to starvation  identical protein binding  acetyl-CoA catabolic process  ketone body biosynthetic process  ketone body catabolic process  ketone body catabolic process  adipose tissue development  extracellular exosome  metanephric proximal convoluted tubule development  coenzyme A binding  ketone body metabolic process  propionyl-CoA biosynthetic process  
Pathways : BIOCARTALow-density lipoprotein (LDL) pathway during atherogenesis [Genes]   
Pathways : KEGGFatty acid degradation    Synthesis and degradation of ketone bodies    Valine, leucine and isoleucine degradation    Lysine degradation    Tryptophan metabolism    Pyruvate metabolism    Glyoxylate and dicarboxylate metabolism    Propanoate metabolism    Butanoate metabolism    Terpenoid backbone biosynthesis   
NDEx NetworkACAT1
Atlas of Cancer Signalling NetworkACAT1
Wikipedia pathwaysACAT1
Orthology - Evolution
OrthoDB38
GeneTree (enSembl)ENSG00000075239
Phylogenetic Trees/Animal Genes : TreeFamACAT1
Homologs : HomoloGeneACAT1
Homology/Alignments : Family Browser (UCSC)ACAT1
Gene fusions - Rearrangements
Fusion : QuiverACAT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerACAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACAT1
dbVarACAT1
ClinVarACAT1
MonarchACAT1
1000_GenomesACAT1 
Exome Variant ServerACAT1
GNOMAD BrowserENSG00000075239
Varsome BrowserACAT1
ACMGACAT1 variants
VarityP24752
Genomic Variants (DGV)ACAT1 [DGVbeta]
DECIPHERACAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisACAT1 
Mutations
ICGC Data PortalACAT1 
TCGA Data PortalACAT1 
Broad Tumor PortalACAT1
OASIS PortalACAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICACAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DACAT1
Mutations and Diseases : HGMDACAT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaACAT1
DgiDB (Drug Gene Interaction Database)ACAT1
DoCM (Curated mutations)ACAT1
CIViC (Clinical Interpretations of Variants in Cancer)ACAT1
Cancer3DACAT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM203750    607809   
Orphanet713   
DisGeNETACAT1
MedgenACAT1
Genetic Testing Registry ACAT1
NextProtP24752 [Medical]
GENETestsACAT1
Target ValidationACAT1
Huge Navigator ACAT1 [HugePedia]
ClinGenACAT1
Clinical trials, drugs, therapy
MyCancerGenomeACAT1
Protein Interactions : CTDACAT1
Pharm GKB GenePA24431
PharosP24752
Clinical trialACAT1
Miscellaneous
canSAR (ICR)ACAT1
HarmonizomeACAT1
DataMed IndexACAT1
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXACAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 14:58:10 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.