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ACE2 (angiotensin I converting enzyme 2)

Identity

Other namesACEH
HGNC (Hugo) ACE2
LocusID (NCBI) 59272
Atlas_Id 552
Location Xp22.2
Location_base_pair Starts at 15579156 and ends at 15620192 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ACE2   13557
Cards
Entrez_Gene (NCBI)ACE2  59272  angiotensin I converting enzyme 2
GeneCards (Weizmann)ACE2
Ensembl hg19 (Hinxton)ENSG00000130234 [Gene_View]  chrX:15579156-15620192 [Contig_View]  ACE2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130234 [Gene_View]  chrX:15579156-15620192 [Contig_View]  ACE2 [Vega]
ICGC DataPortalENSG00000130234
TCGA cBioPortalACE2
AceView (NCBI)ACE2
Genatlas (Paris)ACE2
WikiGenes59272
SOURCE (Princeton)ACE2
Genomic and cartography
GoldenPath hg19 (UCSC)ACE2  -     chrX:15579156-15620192 -  Xp22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACE2  -     Xp22.2   [Description]    (hg38-Dec_2013)
EnsemblACE2 - Xp22.2 [CytoView hg19]  ACE2 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBIACE2 [Mapview hg19]  ACE2 [Mapview hg38]
OMIM300335   
Gene and transcription
Genbank (Entrez)AB046569 AB193259 AB193260 AF241254 AF291820
RefSeq transcript (Entrez)NM_021804
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012575 NT_167197 NW_004929438
Consensus coding sequences : CCDS (NCBI)ACE2
Cluster EST : UnigeneHs.178098 [ NCBI ]
CGAP (NCI)Hs.178098
Alternative Splicing : Fast-db (Paris)GSHG0031988
Alternative Splicing GalleryENSG00000130234
Gene ExpressionACE2 [ NCBI-GEO ]     ACE2 [ SEEK ]   ACE2 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)59272
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYF1 (Uniprot)
NextProtQ9BYF1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYF1
Splice isoforms : SwissVarQ9BYF1 (Swissvar)
Catalytic activity : Enzyme3.4.17.23 [ Enzyme-Expasy ]   3.4.17.23 [ Enzyme-SRS ]   3.4.17.23 [ IntEnz-EBI ]   3.4.17.23 [ PRIAM ]   3.4.17.23 [ BRENDA ]   3.4.17.23 [ KEGG ]   3.4.17.23 [ IUBMB ]
PhosPhoSitePlusQ9BYF1
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Peptidase_M2   
Domain families : Pfam (Sanger)Peptidase_M2 (PF01401)   
Domain families : Pfam (NCBI)pfam01401   
DMDM Disease mutations59272
Blocks (Seattle)ACE2
PDB (SRS)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
PDB (PDBSum)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
PDB (IMB)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
PDB (RSDB)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
Structural Biology KnowledgeBase1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
SCOP (Structural Classification of Proteins)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
CATH (Classification of proteins structures)1R42    1R4L    1XJP    2AJF    3D0G    3D0H    3D0I    3KBH    3SCI    3SCJ    3SCK    3SCL   
Human Protein AtlasENSG00000130234
Peptide AtlasQ9BYF1
HPRD02274
IPIIPI00465187   IPI00619939   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYF1
IntAct (EBI)Q9BYF1
FunCoupENSG00000130234
BioGRIDACE2
IntegromeDBACE2
STRING (EMBL)ACE2
ZODIACACE2
Ontologies - Pathways
QuickGOQ9BYF1
Ontology : AmiGOvirus receptor activity  virus receptor activity  regulation of cytokine production  glycoprotein binding  angiotensin maturation  angiotensin catabolic process in blood  angiotensin-mediated drinking behavior  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  endopeptidase activity  carboxypeptidase activity  protein binding  extracellular region  extracellular space  cytoplasm  plasma membrane  plasma membrane  metallopeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  cell surface  tryptophan transport  integral component of membrane  regulation of vasoconstriction  receptor biosynthetic process  regulation of cell proliferation  regulation of vasodilation  cellular protein metabolic process  membrane raft  viral entry into host cell  receptor-mediated virion attachment to host cell  regulation of inflammatory response  positive regulation of cardiac muscle contraction  extracellular exosome  positive regulation of gap junction assembly  regulation of cardiac conduction  positive regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIvirus receptor activity  virus receptor activity  regulation of cytokine production  glycoprotein binding  angiotensin maturation  angiotensin catabolic process in blood  angiotensin-mediated drinking behavior  regulation of systemic arterial blood pressure by renin-angiotensin  regulation of systemic arterial blood pressure by renin-angiotensin  endopeptidase activity  carboxypeptidase activity  protein binding  extracellular region  extracellular space  cytoplasm  plasma membrane  plasma membrane  metallopeptidase activity  peptidyl-dipeptidase activity  zinc ion binding  cell surface  tryptophan transport  integral component of membrane  regulation of vasoconstriction  receptor biosynthetic process  regulation of cell proliferation  regulation of vasodilation  cellular protein metabolic process  membrane raft  viral entry into host cell  receptor-mediated virion attachment to host cell  regulation of inflammatory response  positive regulation of cardiac muscle contraction  extracellular exosome  positive regulation of gap junction assembly  regulation of cardiac conduction  positive regulation of reactive oxygen species metabolic process  
Pathways : BIOCARTAAngiotensin-converting enzyme 2 regulates heart function [Genes]   
Pathways : KEGGRenin-angiotensin system    Protein digestion and absorption   
Protein Interaction DatabaseACE2
Atlas of Cancer Signalling NetworkACE2
Wikipedia pathwaysACE2
Orthology - Evolution
OrthoDB59272
GeneTree (enSembl)ENSG00000130234
Phylogenetic Trees/Animal Genes : TreeFamACE2
Homologs : HomoloGeneACE2
Homology/Alignments : Family Browser (UCSC)ACE2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerACE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACE2
dbVarACE2
ClinVarACE2
1000_GenomesACE2 
Exome Variant ServerACE2
Exome Aggregation Consortium (ExAC)ENSG00000130234
SNP (GeneSNP Utah)ACE2
SNP : HGBaseACE2
Genetic variants : HAPMAPACE2
Genomic Variants (DGV)ACE2 [DGVbeta]
Mutations
ICGC Data PortalACE2 
TCGA Data PortalACE2 
Tumor PortalACE2
TCGA Copy Number PortalACE2
Somatic Mutations in Cancer : COSMICACE2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ACE2
DgiDB (Drug Gene Interaction Database)ACE2
DoCM (Curated mutations)ACE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACE2 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:15579156-15620192
CONAN: Copy Number AnalysisACE2 
Mutations and Diseases : HGMDACE2
OMIM300335   
MedgenACE2
NextProtQ9BYF1 [Medical]
TSGene59272
GENETestsACE2
Huge Navigator ACE2 [HugePedia]  ACE2 [HugeCancerGEM]
snp3D : Map Gene to Disease59272
BioCentury BCIQACE2
General knowledge
Chemical/Protein Interactions : CTD59272
Chemical/Pharm GKB GenePA425
Clinical trialACE2
Other databases
Probes
Litterature
PubMed212 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACE2
GoPubMedACE2
iHOPACE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 18:04:03 CET 2016

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