Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 59272
MIM: 300335
HGNC: 13557
Ensembl: ENSG00000130234
Variants:
dbSNP: 59272
ClinVar: 59272
TCGA: ENSG00000130234
COSMIC: ACE2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000130234 | ENST00000252519 | Q9BYF1 |
| ENSG00000130234 | ENST00000427411 | Q9BYF1 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 17473847 | |
| PA448780 | captopril | Chemical | ClinicalAnnotation | associated | PD | 17473847 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37286365 | 2024 | Structural basis for the mechanism of interaction of SARS-CoV-2 B.1.640.2 variant RBD with the host receptors hACE2 and GRP78. | 0 |
| 37326579 | 2024 | The relationship between the clinical course of SARS-CoV-2 infections and ACE2 and TMPRSS2 expression and polymorphisms. | 2 |
| 37884208 | 2024 | Integrin αvβ1 facilitates ACE2-mediated entry of SARS-CoV-2. | 0 |
| 38246035 | 2024 | Increased ACE2 and TMPRSS2 expression in ulcerative colitis. | 0 |
| 38263160 | 2024 | Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt. | 0 |
| 38279353 | 2024 | Differential Ability of Spike Protein of SARS-CoV-2 Variants to Downregulate ACE2. | 0 |
| 38287822 | 2024 | ACE2 Regulates Glycolipid Metabolism in Multiple Tissues. | 1 |
| 38307396 | 2024 | Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes. | 0 |
| 38310477 | 2024 | Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2. | 0 |
| 38367677 | 2024 | Polymorphisms in the human angiotensin converting enzyme gene (ACE) linked to susceptibility of COVID-19 and malaria infections in the Ghanaian population. | 0 |
| 38375778 | 2024 | Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1. | 1 |
| 38408924 | 2024 | Nasopharyngeal angiotensin converting enzyme 2 (ACE2) expression as a risk-factor for SARS-CoV-2 transmission in concurrent hospital associated outbreaks. | 0 |
| 38462662 | 2024 | Serum ACE2 and S19P gene polymorphism in Egyptian patients with COVID-19 infection: correlation with disease severity. | 0 |
| 38470058 | 2024 | ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells. | 1 |
| 38489333 | 2024 | Pathological changes in oral epithelium and the expression of SARS-CoV-2 entry receptors, ACE2 and furin. | 0 |
Citation
Dessen P
ACE2 (angiotensin converting enzyme 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/552/ace2
