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ACSL6 (acyl-CoA synthetase long-chain family member 6)

Identity

Other namesACS2
FACL6
LACS 6
LACS2
LACS5
HGNC (Hugo) ACSL6
LocusID (NCBI) 23305
Location 5q31.1
Location_base_pair Starts at 131285667 and ends at 131347355 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)ACSL6   16496
Cards
Entrez_Gene (NCBI)ACSL6  23305  acyl-CoA synthetase long-chain family member 6
GeneCards (Weizmann)ACSL6
Ensembl (Hinxton)ENSG00000164398 [Gene_View]  chr5:131285667-131347355 [Contig_View]  ACSL6 [Vega]
ICGC DataPortalENSG00000164398
cBioPortalACSL6
AceView (NCBI)ACSL6
Genatlas (Paris)ACSL6
WikiGenes23305
SOURCE (Princeton)NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_015256
Genomic and cartography
GoldenPath (UCSC)ACSL6  -  5q31.1   chr5:131285667-131347355 -  5q31.1   [Description]    (hg19-Feb_2009)
EnsemblACSL6 - 5q31.1 [CytoView]
Mapping of homologs : NCBIACSL6 [Mapview]
OMIM604443   
Gene and transcription
Genbank (Entrez)AB020644 AF099740 AF102845 AF129166 AK122702
RefSeq transcript (Entrez)NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_015256
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NG_028290 NT_034772 NW_001838952 NW_004929323
Consensus coding sequences : CCDS (NCBI)ACSL6
Cluster EST : UnigeneHs.14945 [ NCBI ]
CGAP (NCI)Hs.14945
Alternative Splicing : Fast-db (Paris)GSHG0025042
Alternative Splicing GalleryENSG00000164398
Gene ExpressionACSL6 [ NCBI-GEO ]     ACSL6 [ SEEK ]   ACSL6 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKU0 (Uniprot)
NextProtQ9UKU0  [Medical]
With graphics : InterProQ9UKU0
Splice isoforms : SwissVarQ9UKU0 (Swissvar)
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS [organisation]   AMP-dep_Synth/Lig [organisation]  
Related proteins : CluSTrQ9UKU0
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
DMDM Disease mutations23305
Blocks (Seattle)Q9UKU0
Human Protein AtlasENSG00000164398 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9UKU0
HPRD09190
IPIIPI00657883   IPI00657816   IPI00296333   IPI00939479   IPI00879209   IPI00384110   IPI00658107   IPI00657924   IPI00874262   IPI00943183   IPI00657818   IPI00795177   IPI00796262   IPI00879154   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKU0
IntAct (EBI)Q9UKU0
FunCoupENSG00000164398
BioGRIDACSL6
InParanoidQ9UKU0
Interologous Interaction database Q9UKU0
IntegromeDBACSL6
STRING (EMBL)ACSL6
Ontologies - Pathways
Ontology : AmiGOresponse to hypoxia  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  nucleus  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  acyl-CoA metabolic process  neuroblast proliferation  response to nutrient  phospholipid biosynthetic process  response to gravity  positive regulation of plasma membrane long-chain fatty acid transport  positive regulation of triglyceride biosynthetic process  positive regulation of neuron projection development  fatty acid transport  membrane  integral component of membrane  triglyceride biosynthetic process  enzyme binding  cellular response to insulin stimulus  long-chain fatty-acyl-CoA biosynthetic process  protein homodimerization activity  cellular lipid metabolic process  small molecule metabolic process  response to steroid hormone  neuron development  
Ontology : EGO-EBIresponse to hypoxia  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  nucleus  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  acyl-CoA metabolic process  neuroblast proliferation  response to nutrient  phospholipid biosynthetic process  response to gravity  positive regulation of plasma membrane long-chain fatty acid transport  positive regulation of triglyceride biosynthetic process  positive regulation of neuron projection development  fatty acid transport  membrane  integral component of membrane  triglyceride biosynthetic process  enzyme binding  cellular response to insulin stimulus  long-chain fatty-acyl-CoA biosynthetic process  protein homodimerization activity  cellular lipid metabolic process  small molecule metabolic process  response to steroid hormone  neuron development  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
Protein Interaction DatabaseACSL6
Wikipedia pathwaysACSL6
Gene fusion - rearrangments
Rearrangement : TICdbETV6 [12p13.2]  -  ACSL6 [12q13.12]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ACSL6
snp3D : Map Gene to Disease23305
SNP (GeneSNP Utah)ACSL6
SNP : HGBaseACSL6
Genetic variants : HAPMAPACSL6
Exome VariantACSL6
1000_GenomesACSL6 
ICGC programENSG00000164398 
Cancer Gene: CensusACSL6 
Somatic Mutations in Cancer : COSMICACSL6 
CONAN: Copy Number AnalysisACSL6 
Mutations and Diseases : HGMDACSL6
Mutations and Diseases : intOGenACSL6
Genomic VariantsACSL6  ACSL6 [DGVbeta]
dbVarACSL6
ClinVarACSL6
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM604443   
MedgenACSL6
GENETestsACSL6
Disease Genetic AssociationACSL6
Huge Navigator ACSL6 [HugePedia]  ACSL6 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneACSL6
Homology/Alignments : Family Browser (UCSC)ACSL6
Phylogenetic Trees/Animal Genes : TreeFamACSL6
Chemical/Protein Interactions : CTD23305
Chemical/Pharm GKB GenePA27970
Clinical trialACSL6
Cancer Resource (Charite)ENSG00000164398
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
CoreMineACSL6
iHOPACSL6
OncoSearchACSL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 18:36:45 CEST 2014

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