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ACSL6 (acyl-CoA synthetase long-chain family member 6)

Identity

Other namesACS2
FACL6
LACS
LACS2
LACS5
HGNC (Hugo) ACSL6
LocusID (NCBI) 23305
Atlas_Id 560
Location 5q31.1
Location_base_pair Starts at 131285667 and ends at 131347355 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACSL6 (5q31.1) / ACSL6 (5q31.1)ACSL6 (5q31.1) / ETV6 (12p13.2)ETV6 (12p13.2) / ACSL6 (5q31.1)
PLIN1 (15q26.1) / ACSL6 (5q31.1)PLIN1 15q26.1 / ACSL6 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;12)(q31;p13) ETV6/ACSL6 in MDS,AML and AEL

External links

Nomenclature
HGNC (Hugo)ACSL6   16496
Cards
Entrez_Gene (NCBI)ACSL6  23305  acyl-CoA synthetase long-chain family member 6
GeneCards (Weizmann)ACSL6
Ensembl hg19 (Hinxton)ENSG00000164398 [Gene_View]  chr5:131285667-131347355 [Contig_View]  ACSL6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164398 [Gene_View]  chr5:131285667-131347355 [Contig_View]  ACSL6 [Vega]
ICGC DataPortalENSG00000164398
TCGA cBioPortalACSL6
AceView (NCBI)ACSL6
Genatlas (Paris)ACSL6
WikiGenes23305
SOURCE (Princeton)ACSL6
Genomic and cartography
GoldenPath hg19 (UCSC)ACSL6  -     chr5:131285667-131347355 -  5q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ACSL6  -     5q31.1   [Description]    (hg38-Dec_2013)
EnsemblACSL6 - 5q31.1 [CytoView hg19]  ACSL6 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBIACSL6 [Mapview hg19]  ACSL6 [Mapview hg38]
OMIM604443   
Gene and transcription
Genbank (Entrez)AB020644 AF102845 AF129166 AK122702 AK294291
RefSeq transcript (Entrez)NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_015256
RefSeq genomic (Entrez)NC_000005 NC_018916 NG_028290 NT_034772 NW_004929323
Consensus coding sequences : CCDS (NCBI)ACSL6
Cluster EST : UnigeneHs.14945 [ NCBI ]
CGAP (NCI)Hs.14945
Alternative Splicing : Fast-db (Paris)GSHG0025042
Alternative Splicing GalleryENSG00000164398
Gene ExpressionACSL6 [ NCBI-GEO ]   ACSL6 [ EBI - ARRAY_EXPRESS ]   ACSL6 [ SEEK ]   ACSL6 [ MEM ]
Gene Expression Viewer (FireBrowse)ACSL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)23305
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKU0 (Uniprot)
NextProtQ9UKU0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKU0
Splice isoforms : SwissVarQ9UKU0 (Swissvar)
Catalytic activity : Enzyme6.2.1.3 [ Enzyme-Expasy ]   6.2.1.36.2.1.3 [ IntEnz-EBI ]   6.2.1.3 [ BRENDA ]   6.2.1.3 [ KEGG ]   
PhosPhoSitePlusQ9UKU0
Domaine pattern : Prosite (Expaxy)AMP_BINDING (PS00455)   
Domains : Interpro (EBI)AMP-binding_CS    AMP-dep_Synth/Lig   
Domain families : Pfam (Sanger)AMP-binding (PF00501)   
Domain families : Pfam (NCBI)pfam00501   
DMDM Disease mutations23305
Blocks (Seattle)ACSL6
SuperfamilyQ9UKU0
Human Protein AtlasENSG00000164398
Peptide AtlasQ9UKU0
HPRD09190
IPIIPI00657883   IPI00657816   IPI00296333   IPI00939479   IPI00879209   IPI00384110   IPI00658107   IPI00657924   IPI00874262   IPI00943183   IPI00657818   IPI00795177   IPI00796262   IPI00879154   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKU0
IntAct (EBI)Q9UKU0
FunCoupENSG00000164398
BioGRIDACSL6
STRING (EMBL)ACSL6
ZODIACACSL6
Ontologies - Pathways
QuickGOQ9UKU0
Ontology : AmiGOlong-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  acyl-CoA metabolic process  membrane  integral component of membrane  enzyme binding  long-chain fatty-acyl-CoA biosynthetic process  protein homodimerization activity  
Ontology : EGO-EBIlong-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid metabolic process  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  long-chain fatty acid-CoA ligase activity  ATP binding  mitochondrial outer membrane  peroxisomal membrane  endoplasmic reticulum membrane  plasma membrane  acyl-CoA metabolic process  membrane  integral component of membrane  enzyme binding  long-chain fatty-acyl-CoA biosynthetic process  protein homodimerization activity  
Pathways : KEGGFatty acid degradation    PPAR signaling pathway    Peroxisome    Adipocytokine signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkACSL6
Wikipedia pathwaysACSL6
Orthology - Evolution
OrthoDB23305
GeneTree (enSembl)ENSG00000164398
Phylogenetic Trees/Animal Genes : TreeFamACSL6
Homologs : HomoloGeneACSL6
Homology/Alignments : Family Browser (UCSC)ACSL6
Gene fusions - Rearrangements
Fusion: TCGAPLIN1 15q26.1 ACSL6 5q31.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerACSL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ACSL6
dbVarACSL6
ClinVarACSL6
1000_GenomesACSL6 
Exome Variant ServerACSL6
ExAC (Exome Aggregation Consortium)ACSL6 (select the gene name)
SNP (GeneSNP Utah)ACSL6
SNP : HGBaseACSL6
Genetic variants : HAPMAPACSL6
Genomic Variants (DGV)ACSL6 [DGVbeta]
Mutations
ICGC Data PortalACSL6 
TCGA Data PortalACSL6 
Broad Tumor PortalACSL6
OASIS PortalACSL6 [ Somatic mutations - Copy number]
Cancer Gene: CensusACSL6 
Somatic Mutations in Cancer : COSMICACSL6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ACSL6
DgiDB (Drug Gene Interaction Database)ACSL6
DoCM (Curated mutations)ACSL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ACSL6 (select a term)
intoGenACSL6
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:131285667-131347355
CONAN: Copy Number AnalysisACSL6 
Mutations and Diseases : HGMDACSL6
OMIM604443   
MedgenACSL6
Genetic Testing Registry ACSL6
NextProtQ9UKU0 [Medical]
TSGene23305
GENETestsACSL6
Huge Navigator ACSL6 [HugePedia]  ACSL6 [HugeCancerGEM]
snp3D : Map Gene to Disease23305
BioCentury BCIQACSL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23305
Chemical/Pharm GKB GenePA27970
Clinical trialACSL6
Miscellaneous
canSAR (ICR)ACSL6 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineACSL6
GoPubMedACSL6
iHOPACSL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:34:36 CEST 2016

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