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ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Other alias-
HGNC (Hugo) ADAMTS14
LocusID (NCBI) 140766
Atlas_Id 46785
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70672506 and ends at 70762439 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SGPL1 (10q22.1) / ADAMTS14 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADAMTS14   14899
Cards
Entrez_Gene (NCBI)ADAMTS14  140766  ADAM metallopeptidase with thrombospondin type 1 motif 14
Aliases
GeneCards (Weizmann)ADAMTS14
Ensembl hg19 (Hinxton)ENSG00000138316 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138316 [Gene_View]  ENSG00000138316 [Sequence]  chr10:70672506-70762439 [Contig_View]  ADAMTS14 [Vega]
ICGC DataPortalENSG00000138316
TCGA cBioPortalADAMTS14
AceView (NCBI)ADAMTS14
Genatlas (Paris)ADAMTS14
WikiGenes140766
SOURCE (Princeton)ADAMTS14
Genetics Home Reference (NIH)ADAMTS14
Genomic and cartography
GoldenPath hg38 (UCSC)ADAMTS14  -     chr10:70672506-70762439 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADAMTS14  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblADAMTS14 - 10q22.1 [CytoView hg19]  ADAMTS14 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIADAMTS14 [Mapview hg19]  ADAMTS14 [Mapview hg38]
OMIM607506   
Gene and transcription
Genbank (Entrez)AF358666 AF366351 AJ345098 AK128469 CN398634
RefSeq transcript (Entrez)NM_080722 NM_139155
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS14
Cluster EST : UnigeneHs.352156 [ NCBI ]
CGAP (NCI)Hs.352156
Alternative Splicing GalleryENSG00000138316
Gene ExpressionADAMTS14 [ NCBI-GEO ]   ADAMTS14 [ EBI - ARRAY_EXPRESS ]   ADAMTS14 [ SEEK ]   ADAMTS14 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)140766
GTEX Portal (Tissue expression)ADAMTS14
Human Protein AtlasENSG00000138316-ADAMTS14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXS8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXS8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXS8
Splice isoforms : SwissVarQ8WXS8
Catalytic activity : Enzyme3.4.24.- [ Enzyme-Expasy ]   3.4.24.-3.4.24.- [ IntEnz-EBI ]   3.4.24.- [ BRENDA ]   3.4.24.- [ KEGG ]   
PhosPhoSitePlusQ8WXS8
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_Cys-rich    ADAM_spacer1    MetalloPept_cat_dom_sf    Peptidase_M12B    Peptidase_M12B_N    PLAC    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)ACR (SM00608)  TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS14
DMDM Disease mutations140766
Blocks (Seattle)ADAMTS14
SuperfamilyQ8WXS8
Human Protein Atlas [tissue]ENSG00000138316-ADAMTS14 [tissue]
Peptide AtlasQ8WXS8
HPRD06329
IPIIPI00103606   IPI00219596   IPI00219597   IPI00219598   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXS8
IntAct (EBI)Q8WXS8
FunCoupENSG00000138316
BioGRIDADAMTS14
STRING (EMBL)ADAMTS14
ZODIACADAMTS14
Ontologies - Pathways
QuickGOQ8WXS8
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  proteolysis  collagen fibril organization  collagen catabolic process  metal ion binding  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  proteolysis  collagen fibril organization  collagen catabolic process  metal ion binding  
NDEx NetworkADAMTS14
Atlas of Cancer Signalling NetworkADAMTS14
Wikipedia pathwaysADAMTS14
Orthology - Evolution
OrthoDB140766
GeneTree (enSembl)ENSG00000138316
Phylogenetic Trees/Animal Genes : TreeFamADAMTS14
HOVERGENQ8WXS8
HOGENOMQ8WXS8
Homologs : HomoloGeneADAMTS14
Homology/Alignments : Family Browser (UCSC)ADAMTS14
Gene fusions - Rearrangements
Fusion : QuiverADAMTS14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS14
dbVarADAMTS14
ClinVarADAMTS14
1000_GenomesADAMTS14 
Exome Variant ServerADAMTS14
ExAC (Exome Aggregation Consortium)ENSG00000138316
GNOMAD BrowserENSG00000138316
Varsome BrowserADAMTS14
Genetic variants : HAPMAP140766
Genomic Variants (DGV)ADAMTS14 [DGVbeta]
DECIPHERADAMTS14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADAMTS14 
Mutations
ICGC Data PortalADAMTS14 
TCGA Data PortalADAMTS14 
Broad Tumor PortalADAMTS14
OASIS PortalADAMTS14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS14
DgiDB (Drug Gene Interaction Database)ADAMTS14
DoCM (Curated mutations)ADAMTS14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS14 (select a term)
intoGenADAMTS14
Cancer3DADAMTS14(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607506   
Orphanet
DisGeNETADAMTS14
MedgenADAMTS14
Genetic Testing Registry ADAMTS14
NextProtQ8WXS8 [Medical]
TSGene140766
GENETestsADAMTS14
Target ValidationADAMTS14
Huge Navigator ADAMTS14 [HugePedia]
snp3D : Map Gene to Disease140766
BioCentury BCIQADAMTS14
ClinGenADAMTS14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD140766
Chemical/Pharm GKB GenePA24540
Clinical trialADAMTS14
Miscellaneous
canSAR (ICR)ADAMTS14 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS14
EVEXADAMTS14
GoPubMedADAMTS14
iHOPADAMTS14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:49:45 CET 2018
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