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ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)

Identity

Alias_namesa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif
Alias_symbol (synonym)ADAMTS-3
hPCPNI
PCINP
ADAM-TS2
NPI
Other aliasADAMTS-2
PC I-NP
PCI-NP
PCPNI
PNPI
HGNC (Hugo) ADAMTS2
LocusID (NCBI) 9509
Atlas_Id 56454
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 178537852 and ends at 178772431 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR2 (2p14) / ADAMTS2 (5q35.3)ADAMTS2 (5q35.3) / RNF130 (5q35.3)ADAMTS2 (5q35.3) / RPL11 (1p36.11)
AKAP8L (19p13.12) / ADAMTS2 (5q35.3)SYN1 (Xp11.23) / ADAMTS2 (5q35.3)WBP1L (10q24.32) / ADAMTS2 (5q35.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADAMTS2   218
Cards
Entrez_Gene (NCBI)ADAMTS2  9509  ADAM metallopeptidase with thrombospondin type 1 motif 2
AliasesADAM-TS2; ADAMTS-2; ADAMTS-3; NPI; 
PC; PCI-NP; PCINP; PCPNI; PNPI
GeneCards (Weizmann)ADAMTS2
Ensembl hg19 (Hinxton)ENSG00000087116 [Gene_View]  chr5:178537852-178772431 [Contig_View]  ADAMTS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000087116 [Gene_View]  chr5:178537852-178772431 [Contig_View]  ADAMTS2 [Vega]
ICGC DataPortalENSG00000087116
TCGA cBioPortalADAMTS2
AceView (NCBI)ADAMTS2
Genatlas (Paris)ADAMTS2
WikiGenes9509
SOURCE (Princeton)ADAMTS2
Genetics Home Reference (NIH)ADAMTS2
Genomic and cartography
GoldenPath hg19 (UCSC)ADAMTS2  -     chr5:178537852-178772431 -  5q35.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ADAMTS2  -     5q35.3   [Description]    (hg38-Dec_2013)
EnsemblADAMTS2 - 5q35.3 [CytoView hg19]  ADAMTS2 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIADAMTS2 [Mapview hg19]  ADAMTS2 [Mapview hg38]
OMIM225410   604539   
Gene and transcription
Genbank (Entrez)-
RefSeq transcript (Entrez)NM_014244 NM_021599
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADAMTS2
Cluster EST : UnigeneHs.23871 [ NCBI ]
CGAP (NCI)Hs.23871
Alternative Splicing GalleryENSG00000087116
Gene ExpressionADAMTS2 [ NCBI-GEO ]   ADAMTS2 [ EBI - ARRAY_EXPRESS ]   ADAMTS2 [ SEEK ]   ADAMTS2 [ MEM ]
Gene Expression Viewer (FireBrowse)ADAMTS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9509
GTEX Portal (Tissue expression)ADAMTS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95450   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95450  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95450
Splice isoforms : SwissVarO95450
Catalytic activity : Enzyme3.4.24.14 [ Enzyme-Expasy ]   3.4.24.143.4.24.14 [ IntEnz-EBI ]   3.4.24.14 [ BRENDA ]   3.4.24.14 [ KEGG ]   
PhosPhoSitePlusO95450
Domaine pattern : Prosite (Expaxy)ADAM_MEPRO (PS50215)    PLAC (PS50900)    TSP1 (PS50092)   
Domains : Interpro (EBI)ADAM_spacer1    MetalloPept_cat_dom    Pept_M12B_ADAM-TS2    Peptidase_M12B    Peptidase_M12B_ADAM-TS    Peptidase_M12B_N    PLAC    TSP1_rpt   
Domain families : Pfam (Sanger)ADAM_spacer1 (PF05986)    Pep_M12B_propep (PF01562)    Reprolysin (PF01421)    TSP_1 (PF00090)   
Domain families : Pfam (NCBI)pfam05986    pfam01562    pfam01421    pfam00090   
Domain families : Smart (EMBL)TSP1 (SM00209)  
Conserved Domain (NCBI)ADAMTS2
DMDM Disease mutations9509
Blocks (Seattle)ADAMTS2
SuperfamilyO95450
Human Protein AtlasENSG00000087116
Peptide AtlasO95450
HPRD05173
IPIIPI00030757   IPI00012366   
Protein Interaction databases
DIP (DOE-UCLA)O95450
IntAct (EBI)O95450
FunCoupENSG00000087116
BioGRIDADAMTS2
STRING (EMBL)ADAMTS2
ZODIACADAMTS2
Ontologies - Pathways
QuickGOO95450
Ontology : AmiGOmetalloendopeptidase activity  extracellular region  proteinaceous extracellular matrix  spermatogenesis  metallopeptidase activity  zinc ion binding  protein processing  collagen fibril organization  lung development  collagen catabolic process  skin development  
Ontology : EGO-EBImetalloendopeptidase activity  extracellular region  proteinaceous extracellular matrix  spermatogenesis  metallopeptidase activity  zinc ion binding  protein processing  collagen fibril organization  lung development  collagen catabolic process  skin development  
NDEx NetworkADAMTS2
Atlas of Cancer Signalling NetworkADAMTS2
Wikipedia pathwaysADAMTS2
Orthology - Evolution
OrthoDB9509
GeneTree (enSembl)ENSG00000087116
Phylogenetic Trees/Animal Genes : TreeFamADAMTS2
HOVERGENO95450
HOGENOMO95450
Homologs : HomoloGeneADAMTS2
Homology/Alignments : Family Browser (UCSC)ADAMTS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADAMTS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADAMTS2
dbVarADAMTS2
ClinVarADAMTS2
1000_GenomesADAMTS2 
Exome Variant ServerADAMTS2
ExAC (Exome Aggregation Consortium)ADAMTS2 (select the gene name)
Genetic variants : HAPMAP9509
Genomic Variants (DGV)ADAMTS2 [DGVbeta]
DECIPHER (Syndromes)5:178537852-178772431  ENSG00000087116
CONAN: Copy Number AnalysisADAMTS2 
Mutations
ICGC Data PortalADAMTS2 
TCGA Data PortalADAMTS2 
Broad Tumor PortalADAMTS2
OASIS PortalADAMTS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADAMTS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADAMTS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADAMTS2
DgiDB (Drug Gene Interaction Database)ADAMTS2
DoCM (Curated mutations)ADAMTS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADAMTS2 (select a term)
intoGenADAMTS2
Cancer3DADAMTS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM225410    604539   
Orphanet4045   
MedgenADAMTS2
Genetic Testing Registry ADAMTS2
NextProtO95450 [Medical]
TSGene9509
GENETestsADAMTS2
Huge Navigator ADAMTS2 [HugePedia]
snp3D : Map Gene to Disease9509
BioCentury BCIQADAMTS2
ClinGenADAMTS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9509
Chemical/Pharm GKB GenePA24546
Clinical trialADAMTS2
Miscellaneous
canSAR (ICR)ADAMTS2 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADAMTS2
EVEXADAMTS2
GoPubMedADAMTS2
iHOPADAMTS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:54:53 CET 2017

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