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ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

Identity

Other namesADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
HGNC (Hugo) ADH5
LocusID (NCBI) 128
Location 4q23
Location_base_pair Starts at 99992130 and ends at 100009939 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADH5   253
Cards
Entrez_Gene (NCBI)ADH5  128  alcohol dehydrogenase 5 (class III), chi polypeptide
GeneCards (Weizmann)ADH5
Ensembl (Hinxton)ENSG00000197894 [Gene_View]  chr4:99992130-100009939 [Contig_View]  ADH5 [Vega]
ICGC DataPortalENSG00000197894
AceView (NCBI)ADH5
Genatlas (Paris)ADH5
WikiGenes128
SOURCE (Princeton)NM_000671
Genomic and cartography
GoldenPath (UCSC)ADH5  -  4q23   chr4:99992130-100009939 -  4q23   [Description]    (hg19-Feb_2009)
EnsemblADH5 - 4q23 [CytoView]
Mapping of homologs : NCBIADH5 [Mapview]
OMIM103710   
Gene and transcription
Genbank (Entrez)AK124994 AK129570 AK312367 BC014665 BC070491
RefSeq transcript (Entrez)NM_000671
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838915 NW_004929320
Consensus coding sequences : CCDS (NCBI)ADH5
Cluster EST : UnigeneHs.78989 [ NCBI ]
CGAP (NCI)Hs.78989
Alternative Splicing : Fast-db (Paris)GSHG0023420
Alternative Splicing GalleryENSG00000197894
Gene ExpressionADH5 [ NCBI-GEO ]     ADH5 [ SEEK ]   ADH5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11766 (Uniprot)
NextProtP11766  [Medical]
With graphics : InterProP11766
Splice isoforms : SwissVarP11766 (Swissvar)
Catalytic activity : Enzyme1.1.1.1 [ Enzyme-Expasy ]   1.1.1.11.1.1.1 [ IntEnz-EBI ]   1.1.1.1 [ BRENDA ]   1.1.1.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)ADH_ZINC (PS00059)   
Domains : Interpro (EBI)ADH_3    ADH_C    ADH_GroES-like    ADH_SF_Zn-type    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom   
Related proteins : CluSTrP11766
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
DMDM Disease mutations128
Blocks (Seattle)P11766
PDB (SRS)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (PDBSum)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (IMB)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (RSDB)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
Human Protein AtlasENSG00000197894
Peptide AtlasP11766
HPRD00064
IPIIPI00746777   IPI00964823   IPI00967028   IPI00964589   IPI00966735   IPI00967275   
Protein Interaction databases
DIP (DOE-UCLA)P11766
IntAct (EBI)P11766
FunCoupENSG00000197894
BioGRIDADH5
InParanoidP11766
Interologous Interaction database P11766
IntegromeDBADH5
STRING (EMBL)ADH5
Ontologies - Pathways
Ontology : AmiGOretinoid metabolic process  respiratory system process  alcohol dehydrogenase (NAD) activity  fatty acid binding  nucleus  mitochondrion  ethanol catabolic process  ethanol oxidation  aging  zinc ion binding  electron carrier activity  peptidyl-cysteine S-nitrosylation  formaldehyde dehydrogenase activity  response to lipopolysaccharide  protein homodimerization activity  positive regulation of blood pressure  formaldehyde catabolic process  response to nitrosative stress  response to redox state  S-(hydroxymethyl)glutathione dehydrogenase activity  extracellular vesicular exosome  
Ontology : EGO-EBIretinoid metabolic process  respiratory system process  alcohol dehydrogenase (NAD) activity  fatty acid binding  nucleus  mitochondrion  ethanol catabolic process  ethanol oxidation  aging  zinc ion binding  electron carrier activity  peptidyl-cysteine S-nitrosylation  formaldehyde dehydrogenase activity  response to lipopolysaccharide  protein homodimerization activity  positive regulation of blood pressure  formaldehyde catabolic process  response to nitrosative stress  response to redox state  S-(hydroxymethyl)glutathione dehydrogenase activity  extracellular vesicular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Fatty acid degradation    Tyrosine metabolism    Retinol metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
Protein Interaction DatabaseADH5
Wikipedia pathwaysADH5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADH5
SNP (GeneSNP Utah)ADH5
SNP : HGBaseADH5
Genetic variants : HAPMAPADH5
1000_GenomesADH5 
ICGC programENSG00000197894 
CONAN: Copy Number AnalysisADH5 
Somatic Mutations in Cancer : COSMICADH5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDADH5
OMIM103710   
MedgenADH5
GENETestsADH5
Disease Genetic AssociationADH5
Huge Navigator ADH5 [HugePedia]  ADH5 [HugeCancerGEM]
Genomic VariantsADH5  ADH5 [DGVbeta]
Exome VariantADH5
dbVarADH5
ClinVarADH5
snp3D : Map Gene to Disease128
General knowledge
Homologs : HomoloGeneADH5
Homology/Alignments : Family Browser (UCSC)ADH5
Phylogenetic Trees/Animal Genes : TreeFamADH5
Chemical/Protein Interactions : CTD128
Chemical/Pharm GKB GenePA24574
Clinical trialADH5
Cancer Resource (Charite)ENSG00000197894
Other databases
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
CoreMineADH5
iHOPADH5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:30:47 CEST 2014

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