ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

2007-02-01  

Identity

HGNC
LOCATION
4q23
LOCUSID
ALIAS
ADH-3,ADHX,AMEDS,BMFS7,FALDH,FDH,GSH-FDH,GSNOR,HEL-S-60p
FUSION GENES

Other Information

Locus ID:

NCBI: 128
MIM: 103710
HGNC: 253
Ensembl: ENSG00000197894

Variants:

dbSNP: 128
ClinVar: 128
TCGA: ENSG00000197894
COSMIC: ADH5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197894ENST00000296412P11766
ENSG00000197894ENST00000296412Q6IRT1
ENSG00000197894ENST00000502590D6R9G2
ENSG00000197894ENST00000503130H0YAG8
ENSG00000197894ENST00000505652D6RFE4
ENSG00000197894ENST00000512659D6RAY0
ENSG00000197894ENST00000626055D6RAY0

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fatty acid degradationKEGGko00071
Tyrosine metabolismKEGGko00350
Retinol metabolismKEGGko00830
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glycolysis / GluconeogenesisKEGGhsa00010
Fatty acid degradationKEGGhsa00071
Tyrosine metabolismKEGGhsa00350
Retinol metabolismKEGGhsa00830
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Metabolic pathwaysKEGGhsa01100
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Ethanol oxidationREACTOMER-HSA-71384

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
189969232009Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.89
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
166856482006Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.63
203714872010S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis.57
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
183313772008Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.43
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
120040592002POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1.30
195966852009Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase.29

Citation

Dessen P

ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43755/adh5