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ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

Identity

Other namesADH-3
ADHX
FALDH
FDH
GSH-FDH
GSNOR
HGNC (Hugo) ADH5
LocusID (NCBI) 128
Location 4q23
Location_base_pair Starts at 99992130 and ends at 100009931 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ADH5   253
Entrez_Gene (NCBI)ADH5  128  alcohol dehydrogenase 5 (class III), chi polypeptide
Cards
GeneCards (Weizmann)ADH5
Ensembl (Hinxton)ENSG00000197894 [Gene_View]  chr4:99992130-100009931 [Contig_View]  ADH5 [Vega]
AceView (NCBI)ADH5
Genatlas (Paris)ADH5
SOURCE (Stanford)NM_000671
Genomic and cartography
GoldenPath (UCSC)ADH5  -  4q23   chr4:99992130-100009931 -  4q23   [Description]    (hg19-Feb_2009)
EnsemblADH5 - 4q23 [CytoView]
Mapping of homologs : NCBIADH5 [Mapview]
OMIM103710   
Gene and transcription
Genbank (Entrez)AK129570 AK226177 AK312367 BC014665 BC070491
RefSeq transcript (SRS)NM_000671
RefSeq transcript (Entrez)NM_000671
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838915 NW_004078021
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_016354 NW_001838915 NW_004078021
Consensus coding sequences : CCDS (NCBI)ADH5
Cluster EST : UnigeneHs.78989 [ SRS ] Hs.78989 [ NCBI ]
CGAP (NCI)Hs.78989
Alternative Splicing : Fast-db (Paris)GSHG0023420
Alternative Splicing GalleryENSG00000197894
Gene ExpressionADH5 [ NCBI-GEO ]   ADH5 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11766 (SRS) P11766 (Uniprot)
NextProtP11766
With graphics : InterProP11766
Splice isoforms : SwissVarP11766(Swissvar)
Domaine pattern : Prosite (SRS)ADH_ZINC (PS00059)   
Domaine pattern : Prosite (Expaxy)ADH_ZINC (PS00059)   
Domains : Interpro (SRS)ADH_3    ADH_C    ADH_GroES-like    ADH_SF_Zn-type    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom   
Domains : Interpro (EBI)ADH_3    ADH_C    ADH_GroES-like    ADH_SF_Zn-type    ADH_Zn_CS    GroES-like    NAD(P)-bd_dom   
Related proteins : CluSTrP11766
Domain families : Pfam (SRS)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (Sanger)ADH_N (PF08240)    ADH_zinc_N (PF00107)   
Domain families : Pfam (NCBI)pfam08240    pfam00107   
DMDM128
Blocks (Seattle)P11766
PDB (SRS)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (PDBSum)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (IMB)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
PDB (RSDB)1M6H    1M6W    1MA0    1MC5    1MP0    1TEH    2FZE    2FZW    3QJ5   
Human Protein AtlasENSG00000197894
HPRD00064
IPIIPI00746777   IPI00964823   IPI00967028   IPI00964589   IPI00966735   IPI00967275   
Protein Interaction databases
DIP (DOE-UCLA)P11766
IntAct (EBI)P11766
FunCoupENSG00000197894
REACTOMEADH5
Protein Interaction Database128
BioGRIDADH5
InParanoidP11766
Interologous Interaction database P11766
IntegromeDBADH5
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ADH5
SNP (GeneSNP Utah)ADH5
SNP : HGBaseADH5
Genetic variants : HAPMAPADH5
Somatic Mutations in Cancer : COSMICADH5 
CONAN: Copy Number AnalysisADH5 
Mutations and Diseases : HGMDADH5
OMIM103710   
GENETests103710   
Disease Genetic AssociationADH5
Huge Navigator ADH5 [HugePedia]  ADH5 [HugeCancerGEM]
Genomic VariantsADH5  ADH5 [DGVbeta]
snp3D : Map Gene to Disease128
General knowledge
Homologs : HomoloGeneADH5
Homology/Alignments : Family Browser (UCSC)ADH5
Phylogenetic Trees/Animal Genes : TreeFamADH5
Catalytic activity : Enzyme1.1.1.1 [ Enzyme-Expasy ]   1.1.1.1 [ Enzyme-SRS ]   1.1.1.1 [ IntEnz-EBI ]   1.1.1.1 [ BRENDA ]   1.1.1.1 [ KEGG ]   
Chemical/Protein Interactions : CTD128
Chemical/Pharm GKB GenePA24574
Clinical trialADH5
Cancer Resource (Charite)ENSG00000197894
Ontology : AmiGOnucleotide binding  retinoid metabolic process  respiratory system process  alcohol dehydrogenase (NAD) activity  fatty acid binding  nucleus  mitochondrion  ethanol catabolic process  ethanol oxidation  aging  zinc ion binding  electron carrier activity  peptidyl-cysteine S-nitrosylation  formaldehyde dehydrogenase activity  response to lipopolysaccharide  protein homodimerization activity  positive regulation of blood pressure  formaldehyde catabolic process  metal ion binding  response to nitrosative stress  response to redox state  S-(hydroxymethyl)glutathione dehydrogenase activity  
Ontology : EGO-EBInucleotide binding  retinoid metabolic process  respiratory system process  alcohol dehydrogenase (NAD) activity  fatty acid binding  nucleus  mitochondrion  ethanol catabolic process  ethanol oxidation  aging  zinc ion binding  electron carrier activity  peptidyl-cysteine S-nitrosylation  formaldehyde dehydrogenase activity  response to lipopolysaccharide  protein homodimerization activity  positive regulation of blood pressure  formaldehyde catabolic process  metal ion binding  response to nitrosative stress  response to redox state  S-(hydroxymethyl)glutathione dehydrogenase activity  
Pathways : KEGGMethane metabolismGlycerolipid metabolism1- and 2-Methylnaphthalene degradationFatty acid metabolismGlycolysis / GluconeogenesisMetabolism of xenobiotics by cytochrome P450Tyrosine metabolismBile acid biosynthesis
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
PubGeneADH5
iHOPADH5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:32:01 CEST 2013
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