ADM2 (adrenomedullin 2)

2009-08-01  

Identity

HGNC
LOCATION
22q13.33
LOCUSID
ALIAS
AM2,dJ579N16.4
FUSION GENES

Other Information

Locus ID:

NCBI: 79924
MIM: 608682
HGNC: 28898
Ensembl: ENSG00000128165

Variants:

dbSNP: 79924
ClinVar: 79924
TCGA: ENSG00000128165
COSMIC: ADM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128165ENST00000395737Q7Z4H4
ENSG00000128165ENST00000395738Q7Z4H4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
146154902004Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.95
179657492008Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems.26
195357892009Expression of adrenomedullin 2 (ADM2)/intermedin (IMD) in human placenta: role in trophoblast invasion and migration.17
196841982009Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability.17
195926122009Intermedin is a new angiogenic growth factor.15
188297382008Intermedin ameliorates vascular and renal injury by inhibition of oxidative stress.13
199104452010Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.13
276213152016Adrenomedullin 2 Enhances Beiging in White Adipose Tissue Directly in an Adipocyte-autonomous Manner and Indirectly through Activation of M2 Macrophages.13
163597542006Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney.11
220097522011Regulation of oocyte and cumulus cell interactions by intermedin/adrenomedullin 2.11

Citation

Dessen P

ADM2 (adrenomedullin 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51044/adm2