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ADORA1 (adenosine A1 receptor)

Identity

Alias_symbol (synonym)RDC7
Other alias
HGNC (Hugo) ADORA1
LocusID (NCBI) 134
Atlas_Id 53078
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 203127708 and ends at 203167405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRCAM (7q31.1) / ADORA1 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADORA1   262
Cards
Entrez_Gene (NCBI)ADORA1  134  adenosine A1 receptor
AliasesRDC7
GeneCards (Weizmann)ADORA1
Ensembl hg19 (Hinxton)ENSG00000163485 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163485 [Gene_View]  chr1:203127708-203167405 [Contig_View]  ADORA1 [Vega]
ICGC DataPortalENSG00000163485
TCGA cBioPortalADORA1
AceView (NCBI)ADORA1
Genatlas (Paris)ADORA1
WikiGenes134
SOURCE (Princeton)ADORA1
Genetics Home Reference (NIH)ADORA1
Genomic and cartography
GoldenPath hg38 (UCSC)ADORA1  -     chr1:203127708-203167405 +  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADORA1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblADORA1 - 1q32.1 [CytoView hg19]  ADORA1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBIADORA1 [Mapview hg19]  ADORA1 [Mapview hg38]
OMIM102775   
Gene and transcription
Genbank (Entrez)AB004662 AK095060 AK127752 AK289928 AK293647
RefSeq transcript (Entrez)NM_000674 NM_001048230
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADORA1
Cluster EST : UnigeneHs.77867 [ NCBI ]
CGAP (NCI)Hs.77867
Alternative Splicing GalleryENSG00000163485
Gene ExpressionADORA1 [ NCBI-GEO ]   ADORA1 [ EBI - ARRAY_EXPRESS ]   ADORA1 [ SEEK ]   ADORA1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADORA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)134
GTEX Portal (Tissue expression)ADORA1
Human Protein AtlasENSG00000163485-ADORA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30542   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30542  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30542
Splice isoforms : SwissVarP30542
PhosPhoSitePlusP30542
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Adeno_A1_rcpt    Adenosn_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADORA1
DMDM Disease mutations134
Blocks (Seattle)ADORA1
SuperfamilyP30542
Human Protein Atlas [tissue]ENSG00000163485-ADORA1 [tissue]
Peptide AtlasP30542
HPRD00042
IPIIPI00645335   IPI00026872   
Protein Interaction databases
DIP (DOE-UCLA)P30542
IntAct (EBI)P30542
FunCoupENSG00000163485
BioGRIDADORA1
STRING (EMBL)ADORA1
ZODIACADORA1
Ontologies - Pathways
QuickGOP30542
Ontology : AmiGOactivation of MAPKK activity  G-protein coupled adenosine receptor activity  temperature homeostasis  G-protein coupled receptor binding  response to hypoxia  purine nucleoside binding  adenosine receptor signaling pathway  regulation of respiratory gaseous exchange by neurological system process  negative regulation of acute inflammatory response  negative regulation of leukocyte migration  positive regulation of peptide secretion  regulation of glomerular filtration  phospholipase C activity  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  integral component of plasma membrane  protein targeting to membrane  phagocytosis  inflammatory response  signal transduction  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  cell-cell signaling  nervous system development  negative regulation of cell proliferation  negative regulation of glutamate secretion  postsynaptic density  lipid catabolic process  basolateral plasma membrane  axolemma  heat shock protein binding  G-protein beta/gamma-subunit complex binding  negative regulation of synaptic transmission, GABAergic  positive regulation of nucleoside transport  heterotrimeric G-protein binding  negative regulation of neurotrophin production  positive regulation of protein dephosphorylation  negative regulation of renal sodium excretion  negative regulation of circadian sleep/wake cycle, non-REM sleep  presynaptic membrane  neuronal cell body  negative regulation of apoptotic process  terminal bouton  dendritic spine  positive regulation of potassium ion transport  postsynaptic membrane  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of blood pressure  positive regulation of blood pressure  negative regulation of hormone secretion  protein heterodimerization activity  presynaptic active zone  cognition  detection of temperature stimulus involved in sensory perception of pain  negative regulation of lipid catabolic process  regulation of sensory perception of pain  negative regulation of synaptic transmission, glutamatergic  negative regulation of cardiac muscle contraction  excitatory postsynaptic potential  relaxation of vascular smooth muscle  negative regulation of mucus secretion  apoptotic signaling pathway  negative regulation of blood vessel diameter  negative regulation of long term synaptic depression  
Ontology : EGO-EBIactivation of MAPKK activity  G-protein coupled adenosine receptor activity  temperature homeostasis  G-protein coupled receptor binding  response to hypoxia  purine nucleoside binding  adenosine receptor signaling pathway  regulation of respiratory gaseous exchange by neurological system process  negative regulation of acute inflammatory response  negative regulation of leukocyte migration  positive regulation of peptide secretion  regulation of glomerular filtration  phospholipase C activity  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  integral component of plasma membrane  protein targeting to membrane  phagocytosis  inflammatory response  signal transduction  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  cell-cell signaling  nervous system development  negative regulation of cell proliferation  negative regulation of glutamate secretion  postsynaptic density  lipid catabolic process  basolateral plasma membrane  axolemma  heat shock protein binding  G-protein beta/gamma-subunit complex binding  negative regulation of synaptic transmission, GABAergic  positive regulation of nucleoside transport  heterotrimeric G-protein binding  negative regulation of neurotrophin production  positive regulation of protein dephosphorylation  negative regulation of renal sodium excretion  negative regulation of circadian sleep/wake cycle, non-REM sleep  presynaptic membrane  neuronal cell body  negative regulation of apoptotic process  terminal bouton  dendritic spine  positive regulation of potassium ion transport  postsynaptic membrane  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of blood pressure  positive regulation of blood pressure  negative regulation of hormone secretion  protein heterodimerization activity  presynaptic active zone  cognition  detection of temperature stimulus involved in sensory perception of pain  negative regulation of lipid catabolic process  regulation of sensory perception of pain  negative regulation of synaptic transmission, glutamatergic  negative regulation of cardiac muscle contraction  excitatory postsynaptic potential  relaxation of vascular smooth muscle  negative regulation of mucus secretion  apoptotic signaling pathway  negative regulation of blood vessel diameter  negative regulation of long term synaptic depression  
Pathways : KEGGNeuroactive ligand-receptor interaction    Morphine addiction   
NDEx NetworkADORA1
Atlas of Cancer Signalling NetworkADORA1
Wikipedia pathwaysADORA1
Orthology - Evolution
OrthoDB134
GeneTree (enSembl)ENSG00000163485
Phylogenetic Trees/Animal Genes : TreeFamADORA1
HOVERGENP30542
HOGENOMP30542
Homologs : HomoloGeneADORA1
Homology/Alignments : Family Browser (UCSC)ADORA1
Gene fusions - Rearrangements
Tumor Fusion PortalADORA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADORA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADORA1
dbVarADORA1
ClinVarADORA1
1000_GenomesADORA1 
Exome Variant ServerADORA1
ExAC (Exome Aggregation Consortium)ENSG00000163485
GNOMAD BrowserENSG00000163485
Genetic variants : HAPMAP134
Genomic Variants (DGV)ADORA1 [DGVbeta]
DECIPHERADORA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADORA1 
Mutations
ICGC Data PortalADORA1 
TCGA Data PortalADORA1 
Broad Tumor PortalADORA1
OASIS PortalADORA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADORA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADORA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADORA1
DgiDB (Drug Gene Interaction Database)ADORA1
DoCM (Curated mutations)ADORA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADORA1 (select a term)
intoGenADORA1
Cancer3DADORA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM102775   
Orphanet
DisGeNETADORA1
MedgenADORA1
Genetic Testing Registry ADORA1
NextProtP30542 [Medical]
TSGene134
GENETestsADORA1
Target ValidationADORA1
Huge Navigator ADORA1 [HugePedia]
snp3D : Map Gene to Disease134
BioCentury BCIQADORA1
ClinGenADORA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD134
Chemical/Pharm GKB GenePA24583
Clinical trialADORA1
Miscellaneous
canSAR (ICR)ADORA1 (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADORA1
EVEXADORA1
GoPubMedADORA1
iHOPADORA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:02:19 CET 2017

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