ADORA1 (adenosine A1 receptor)

2012-12-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
RDC7
FUSION GENES

Other Information

Locus ID:

NCBI: 134
MIM: 102775
HGNC: 262
Ensembl: ENSG00000163485

Variants:

dbSNP: 134
ClinVar: 134
TCGA: ENSG00000163485
COSMIC: ADORA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163485ENST00000309502P30542
ENSG00000163485ENST00000337894P30542
ENSG00000163485ENST00000367235P30542
ENSG00000163485ENST00000367236P30542
ENSG00000163485ENST00000618295A0A087X173
ENSG00000163485ENST00000640524P30542

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Regulation of lipolysis in adipocytesKEGGhsa04923
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
Adenosine P1 receptorsREACTOMER-HSA-417973
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD19019667
PA448497aspirinChemicalClinicalAnnotationassociatedPD19019667

References

Pubmed IDYearTitleCitations
217010652011A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191938742009Control and function of the homeostatic sleep response by adenosine A1 receptors.67
128250922003Association between A2a receptor gene polymorphisms and caffeine-induced anxiety.66
299259452018Structure of the adenosine-bound human adenosine A<sub>1</sub> receptor-G<sub>i</sub> complex.60
222156712012AMP is an adenosine A1 receptor agonist.58
215907342011Adenosine receptor subtype expression and activation influence the differentiation of mesenchymal stem cells to osteoblasts and adipocytes.49
282351982017Structure of the Adenosine A<sub>1</sub> Receptor Reveals the Basis for Subtype Selectivity.48
236576262013A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.35
179013622007A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytes.34

Citation

Dessen P

ADORA1 (adenosine A1 receptor)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53078/adora1