Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRA2C (adrenoceptor alpha 2C)

Identity

Alias_namesADRA2L2
ADRA2RL2
adrenergic
Alias_symbol (synonym)ADRARL2
Other aliasALPHA2CAR
HGNC (Hugo) ADRA2C
LocusID (NCBI) 152
Atlas_Id 52616
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 3766569 and ends at 3768526 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRA2C   283
Cards
Entrez_Gene (NCBI)ADRA2C  152  adrenoceptor alpha 2C
AliasesADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR
GeneCards (Weizmann)ADRA2C
Ensembl hg19 (Hinxton)ENSG00000184160 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184160 [Gene_View]  chr4:3766569-3768526 [Contig_View]  ADRA2C [Vega]
ICGC DataPortalENSG00000184160
TCGA cBioPortalADRA2C
AceView (NCBI)ADRA2C
Genatlas (Paris)ADRA2C
WikiGenes152
SOURCE (Princeton)ADRA2C
Genetics Home Reference (NIH)ADRA2C
Genomic and cartography
GoldenPath hg38 (UCSC)ADRA2C  -     chr4:3766569-3768526 +  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRA2C  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblADRA2C - 4p16.3 [CytoView hg19]  ADRA2C - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIADRA2C [Mapview hg19]  ADRA2C [Mapview hg38]
OMIM104250   
Gene and transcription
Genbank (Entrez)BC142625 J03853
RefSeq transcript (Entrez)NM_000683
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRA2C
Cluster EST : UnigeneHs.123022 [ NCBI ]
CGAP (NCI)Hs.123022
Alternative Splicing GalleryENSG00000184160
Gene ExpressionADRA2C [ NCBI-GEO ]   ADRA2C [ EBI - ARRAY_EXPRESS ]   ADRA2C [ SEEK ]   ADRA2C [ MEM ]
Gene Expression Viewer (FireBrowse)ADRA2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)152
GTEX Portal (Tissue expression)ADRA2C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18825   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18825  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18825
Splice isoforms : SwissVarP18825
PhosPhoSitePlusP18825
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRA2C_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRA2C
DMDM Disease mutations152
Blocks (Seattle)ADRA2C
SuperfamilyP18825
Human Protein AtlasENSG00000184160
Peptide AtlasP18825
HPRD00085
IPIIPI00002437   IPI00964697   
Protein Interaction databases
DIP (DOE-UCLA)P18825
IntAct (EBI)P18825
FunCoupENSG00000184160
BioGRIDADRA2C
STRING (EMBL)ADRA2C
ZODIACADRA2C
Ontologies - Pathways
QuickGOP18825
Ontology : AmiGOalpha2-adrenergic receptor activity  protein binding  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  cell-cell signaling  female pregnancy  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  platelet activation  axon  alpha-2A adrenergic receptor binding  activation of protein kinase B activity  negative regulation of epinephrine secretion  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  protein homodimerization activity  axon terminus  positive regulation of neuron differentiation  positive regulation of vasoconstriction  protein heterodimerization activity  regulation of insulin secretion  epinephrine binding  regulation of sensory perception of pain  negative regulation of uterine smooth muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  
Ontology : EGO-EBIalpha2-adrenergic receptor activity  protein binding  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  cell-cell signaling  female pregnancy  negative regulation of norepinephrine secretion  negative regulation of norepinephrine secretion  platelet activation  axon  alpha-2A adrenergic receptor binding  activation of protein kinase B activity  negative regulation of epinephrine secretion  epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway  protein homodimerization activity  axon terminus  positive regulation of neuron differentiation  positive regulation of vasoconstriction  protein heterodimerization activity  regulation of insulin secretion  epinephrine binding  regulation of sensory perception of pain  negative regulation of uterine smooth muscle contraction  adenylate cyclase-activating adrenergic receptor signaling pathway  activation of MAPK activity by adrenergic receptor signaling pathway  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkADRA2C
Atlas of Cancer Signalling NetworkADRA2C
Wikipedia pathwaysADRA2C
Orthology - Evolution
OrthoDB152
GeneTree (enSembl)ENSG00000184160
Phylogenetic Trees/Animal Genes : TreeFamADRA2C
HOVERGENP18825
HOGENOMP18825
Homologs : HomoloGeneADRA2C
Homology/Alignments : Family Browser (UCSC)ADRA2C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRA2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRA2C
dbVarADRA2C
ClinVarADRA2C
1000_GenomesADRA2C 
Exome Variant ServerADRA2C
ExAC (Exome Aggregation Consortium)ADRA2C (select the gene name)
Genetic variants : HAPMAP152
Genomic Variants (DGV)ADRA2C [DGVbeta]
DECIPHERADRA2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRA2C 
Mutations
ICGC Data PortalADRA2C 
TCGA Data PortalADRA2C 
Broad Tumor PortalADRA2C
OASIS PortalADRA2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRA2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRA2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRA2C
DgiDB (Drug Gene Interaction Database)ADRA2C
DoCM (Curated mutations)ADRA2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRA2C (select a term)
intoGenADRA2C
Cancer3DADRA2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104250   
Orphanet
MedgenADRA2C
Genetic Testing Registry ADRA2C
NextProtP18825 [Medical]
TSGene152
GENETestsADRA2C
Target ValidationADRA2C
Huge Navigator ADRA2C [HugePedia]
snp3D : Map Gene to Disease152
BioCentury BCIQADRA2C
ClinGenADRA2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD152
Chemical/Pharm GKB GenePA37
Clinical trialADRA2C
Miscellaneous
canSAR (ICR)ADRA2C (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRA2C
EVEXADRA2C
GoPubMedADRA2C
iHOPADRA2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:46:19 CEST 2017

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