Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRB1 (adrenoceptor beta 1)

Identity

Alias_namesADRB1R
adrenergic
Other aliasB1AR
BETA1AR
RHR
HGNC (Hugo) ADRB1
LocusID (NCBI) 153
Atlas_Id 47406
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 114044047 and ends at 114046908 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ADRB1   285
Cards
Entrez_Gene (NCBI)ADRB1  153  adrenoceptor beta 1
AliasesADRB1R; B1AR; BETA1AR; RHR
GeneCards (Weizmann)ADRB1
Ensembl hg19 (Hinxton)ENSG00000043591 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000043591 [Gene_View]  chr10:114044047-114046908 [Contig_View]  ADRB1 [Vega]
ICGC DataPortalENSG00000043591
TCGA cBioPortalADRB1
AceView (NCBI)ADRB1
Genatlas (Paris)ADRB1
WikiGenes153
SOURCE (Princeton)ADRB1
Genetics Home Reference (NIH)ADRB1
Genomic and cartography
GoldenPath hg38 (UCSC)ADRB1  -     chr10:114044047-114046908 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRB1  -     10q25.3   [Description]    (hg19-Feb_2009)
EnsemblADRB1 - 10q25.3 [CytoView hg19]  ADRB1 - 10q25.3 [CytoView hg38]
Mapping of homologs : NCBIADRB1 [Mapview hg19]  ADRB1 [Mapview hg38]
OMIM109630   607276   
Gene and transcription
Genbank (Entrez)AF272890 BC169224 BC169225 BC169226 J03019
RefSeq transcript (Entrez)NM_000684
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ADRB1
Cluster EST : UnigeneHs.99913 [ NCBI ]
CGAP (NCI)Hs.99913
Alternative Splicing GalleryENSG00000043591
Gene ExpressionADRB1 [ NCBI-GEO ]   ADRB1 [ EBI - ARRAY_EXPRESS ]   ADRB1 [ SEEK ]   ADRB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADRB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)153
GTEX Portal (Tissue expression)ADRB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08588   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08588  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08588
Splice isoforms : SwissVarP08588
PhosPhoSitePlusP08588
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRB1_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRB1
DMDM Disease mutations153
Blocks (Seattle)ADRB1
PDB (SRS)2LSQ   
PDB (PDBSum)2LSQ   
PDB (IMB)2LSQ   
PDB (RSDB)2LSQ   
Structural Biology KnowledgeBase2LSQ   
SCOP (Structural Classification of Proteins)2LSQ   
CATH (Classification of proteins structures)2LSQ   
SuperfamilyP08588
Human Protein AtlasENSG00000043591
Peptide AtlasP08588
HPRD00181
IPIIPI00029278   
Protein Interaction databases
DIP (DOE-UCLA)P08588
IntAct (EBI)P08588
FunCoupENSG00000043591
BioGRIDADRB1
STRING (EMBL)ADRB1
ZODIACADRB1
Ontologies - Pathways
QuickGOP08588
Ontology : AmiGOtemperature homeostasis  positive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  beta-adrenergic receptor activity  beta1-adrenergic receptor activity  signal transducer activity, downstream of receptor  Ras guanyl-nucleotide exchange factor activity  protein binding  early endosome  plasma membrane  plasma membrane  integral component of plasma membrane  activation of adenylate cyclase activity  cell-cell signaling  response to cold  PDZ domain binding  positive regulation of cAMP biosynthetic process  heat generation  alpha-2A adrenergic receptor binding  negative regulation of multicellular organism growth  fear response  positive regulation of GTPase activity  positive regulation of cAMP-mediated signaling  protein heterodimerization activity  brown fat cell differentiation  epinephrine binding  norepinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  
Ontology : EGO-EBItemperature homeostasis  positive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  beta-adrenergic receptor activity  beta1-adrenergic receptor activity  signal transducer activity, downstream of receptor  Ras guanyl-nucleotide exchange factor activity  protein binding  early endosome  plasma membrane  plasma membrane  integral component of plasma membrane  activation of adenylate cyclase activity  cell-cell signaling  response to cold  PDZ domain binding  positive regulation of cAMP biosynthetic process  heat generation  alpha-2A adrenergic receptor binding  negative regulation of multicellular organism growth  fear response  positive regulation of GTPase activity  positive regulation of cAMP-mediated signaling  protein heterodimerization activity  brown fat cell differentiation  epinephrine binding  norepinephrine binding  adenylate cyclase-activating adrenergic receptor signaling pathway  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Endocytosis    Adrenergic signaling in cardiomyocytes    Gap junction    Salivary secretion    Dilated cardiomyopathy   
NDEx NetworkADRB1
Atlas of Cancer Signalling NetworkADRB1
Wikipedia pathwaysADRB1
Orthology - Evolution
OrthoDB153
GeneTree (enSembl)ENSG00000043591
Phylogenetic Trees/Animal Genes : TreeFamADRB1
HOVERGENP08588
HOGENOMP08588
Homologs : HomoloGeneADRB1
Homology/Alignments : Family Browser (UCSC)ADRB1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRB1
dbVarADRB1
ClinVarADRB1
1000_GenomesADRB1 
Exome Variant ServerADRB1
ExAC (Exome Aggregation Consortium)ADRB1 (select the gene name)
Genetic variants : HAPMAP153
Genomic Variants (DGV)ADRB1 [DGVbeta]
DECIPHERADRB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRB1 
Mutations
ICGC Data PortalADRB1 
TCGA Data PortalADRB1 
Broad Tumor PortalADRB1
OASIS PortalADRB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDADRB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ADRB1
DgiDB (Drug Gene Interaction Database)ADRB1
DoCM (Curated mutations)ADRB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ADRB1 (select a term)
intoGenADRB1
Cancer3DADRB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109630    607276   
Orphanet
MedgenADRB1
Genetic Testing Registry ADRB1
NextProtP08588 [Medical]
TSGene153
GENETestsADRB1
Target ValidationADRB1
Huge Navigator ADRB1 [HugePedia]
snp3D : Map Gene to Disease153
BioCentury BCIQADRB1
ClinGenADRB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD153
Chemical/Pharm GKB GenePA38
Clinical trialADRB1
Miscellaneous
canSAR (ICR)ADRB1 (select the gene name)
Probes
Litterature
PubMed334 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineADRB1
EVEXADRB1
GoPubMedADRB1
iHOPADRB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:23:02 CEST 2017

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