Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ADRB1 (adrenoceptor beta 1)

Identity

Alias (NCBI)ADRB1R
B1AR
BETA1AR
FNSS2
RHR
HGNC (Hugo) ADRB1
HGNC Previous nameADRB1R
HGNC Previous nameadrenergic, beta-1-, receptor
LocusID (NCBI) 153
Atlas_Id 47406
Location 10q25.3  [Link to chromosome band 10q25]
Location_base_pair Starts at 114043866 and ends at 114046904 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ADRB1   285
Cards
Entrez_Gene (NCBI)ADRB1    adrenoceptor beta 1
AliasesADRB1R; B1AR; BETA1AR; FNSS2; 
RHR
GeneCards (Weizmann)ADRB1
Ensembl hg19 (Hinxton)ENSG00000043591 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000043591 [Gene_View]  ENSG00000043591 [Sequence]  chr10:114043866-114046904 [Contig_View]  ADRB1 [Vega]
ICGC DataPortalENSG00000043591
TCGA cBioPortalADRB1
AceView (NCBI)ADRB1
Genatlas (Paris)ADRB1
SOURCE (Princeton)ADRB1
Genetics Home Reference (NIH)ADRB1
Genomic and cartography
GoldenPath hg38 (UCSC)ADRB1  -     chr10:114043866-114046904 +  10q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ADRB1  -     10q25.3   [Description]    (hg19-Feb_2009)
GoldenPathADRB1 - 10q25.3 [CytoView hg19]  ADRB1 - 10q25.3 [CytoView hg38]
ImmunoBaseENSG00000043591
Genome Data Viewer NCBIADRB1 [Mapview hg19]  
OMIM109630   607276   618591   
Gene and transcription
Genbank (Entrez)AF272890 J03019
RefSeq transcript (Entrez)NM_000684
Consensus coding sequences : CCDS (NCBI)ADRB1
Gene ExpressionADRB1 [ NCBI-GEO ]   ADRB1 [ EBI - ARRAY_EXPRESS ]   ADRB1 [ SEEK ]   ADRB1 [ MEM ]
Gene Expression Viewer (FireBrowse)ADRB1 [ Firebrowse - Broad ]
GenevisibleExpression of ADRB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)153
GTEX Portal (Tissue expression)ADRB1
Human Protein AtlasENSG00000043591-ADRB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08588   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08588  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08588
PhosPhoSitePlusP08588
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)ADR_fam    ADRB1_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)ADRB1
PDB (RSDB)2LSQ   
PDB Europe2LSQ   
PDB (PDBSum)2LSQ   
PDB (IMB)2LSQ   
Structural Biology KnowledgeBase2LSQ   
SCOP (Structural Classification of Proteins)2LSQ   
CATH (Classification of proteins structures)2LSQ   
SuperfamilyP08588
AlphaFold pdb e-kbP08588   
Human Protein Atlas [tissue]ENSG00000043591-ADRB1 [tissue]
HPRD00181
Protein Interaction databases
DIP (DOE-UCLA)P08588
IntAct (EBI)P08588
BioGRIDADRB1
STRING (EMBL)ADRB1
ZODIACADRB1
Ontologies - Pathways
QuickGOP08588
Ontology : AmiGOpositive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  negative regulation of inflammatory response to antigenic stimulus  G protein-coupled receptor activity  beta-adrenergic receptor activity  beta1-adrenergic receptor activity  guanyl-nucleotide exchange factor activity  protein binding  early endosome  plasma membrane  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  response to cold  PDZ domain binding  heat generation  alpha-2A adrenergic receptor binding  negative regulation of multicellular organism growth  fear response  positive regulation of GTPase activity  regulation of circadian sleep/wake cycle, sleep  protein heterodimerization activity  brown fat cell differentiation  regulation of postsynaptic membrane potential  adenylate cyclase-activating adrenergic receptor signaling pathway  adenylate cyclase-activating adrenergic receptor signaling pathway  Schaffer collateral - CA1 synapse  G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential  positive regulation of cold-induced thermogenesis  
Ontology : EGO-EBIpositive regulation of heart rate by epinephrine-norepinephrine  positive regulation of the force of heart contraction by epinephrine-norepinephrine  diet induced thermogenesis  norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure  negative regulation of inflammatory response to antigenic stimulus  G protein-coupled receptor activity  beta-adrenergic receptor activity  beta1-adrenergic receptor activity  guanyl-nucleotide exchange factor activity  protein binding  early endosome  plasma membrane  plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  activation of adenylate cyclase activity  response to cold  PDZ domain binding  heat generation  alpha-2A adrenergic receptor binding  negative regulation of multicellular organism growth  fear response  positive regulation of GTPase activity  regulation of circadian sleep/wake cycle, sleep  protein heterodimerization activity  brown fat cell differentiation  regulation of postsynaptic membrane potential  adenylate cyclase-activating adrenergic receptor signaling pathway  adenylate cyclase-activating adrenergic receptor signaling pathway  Schaffer collateral - CA1 synapse  G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential  positive regulation of cold-induced thermogenesis  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Endocytosis    Adrenergic signaling in cardiomyocytes    Gap junction    Salivary secretion    Dilated cardiomyopathy   
NDEx NetworkADRB1
Atlas of Cancer Signalling NetworkADRB1
Wikipedia pathwaysADRB1
Orthology - Evolution
OrthoDB153
GeneTree (enSembl)ENSG00000043591
Phylogenetic Trees/Animal Genes : TreeFamADRB1
Homologs : HomoloGeneADRB1
Homology/Alignments : Family Browser (UCSC)ADRB1
Gene fusions - Rearrangements
Fusion : QuiverADRB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerADRB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ADRB1
dbVarADRB1
ClinVarADRB1
MonarchADRB1
1000_GenomesADRB1 
Exome Variant ServerADRB1
GNOMAD BrowserENSG00000043591
Varsome BrowserADRB1
ACMGADRB1 variants
VarityP08588
Genomic Variants (DGV)ADRB1 [DGVbeta]
DECIPHERADRB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisADRB1 
Mutations
ICGC Data PortalADRB1 
TCGA Data PortalADRB1 
Broad Tumor PortalADRB1
OASIS PortalADRB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICADRB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DADRB1
Mutations and Diseases : HGMDADRB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaADRB1
DgiDB (Drug Gene Interaction Database)ADRB1
DoCM (Curated mutations)ADRB1
CIViC (Clinical Interpretations of Variants in Cancer)ADRB1
Cancer3DADRB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109630    607276    618591   
Orphanet
DisGeNETADRB1
MedgenADRB1
Genetic Testing Registry ADRB1
NextProtP08588 [Medical]
GENETestsADRB1
Target ValidationADRB1
Huge Navigator ADRB1 [HugePedia]
ClinGenADRB1
Clinical trials, drugs, therapy
MyCancerGenomeADRB1
Protein Interactions : CTDADRB1
Pharm GKB GenePA38
Pharm GKB PathwaysPA2042   
PharosP08588
Clinical trialADRB1
Miscellaneous
canSAR (ICR)ADRB1
HarmonizomeADRB1
DataMed IndexADRB1
Probes
Litterature
PubMed374 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXADRB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:44 CEST 2021

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