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AGRN (agrin)

Identity

Other namesCMSPPD
HGNC (Hugo) AGRN
LocusID (NCBI) 375790
Location 1p36.33
Location_base_pair Starts at 955503 and ends at 991499 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AGRN   329
Cards
Entrez_Gene (NCBI)AGRN  375790  agrin
GeneCards (Weizmann)AGRN
Ensembl (Hinxton)ENSG00000188157 [Gene_View]  chr1:955503-991499 [Contig_View]  AGRN [Vega]
ICGC DataPortalENSG00000188157
AceView (NCBI)AGRN
Genatlas (Paris)AGRN
WikiGenes375790
SOURCE (Princeton)NM_198576
Genomic and cartography
GoldenPath (UCSC)AGRN  -  1p36.33   chr1:955503-991499 +  1p36.33   [Description]    (hg19-Feb_2009)
EnsemblAGRN - 1p36.33 [CytoView]
Mapping of homologs : NCBIAGRN [Mapview]
OMIM103320   615120   
Gene and transcription
Genbank (Entrez)AB191264 AF016903 AJ309206 AK021586 AK125197
RefSeq transcript (Entrez)NM_198576
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_016346 NT_032977 NW_001838585 NW_004929288
Consensus coding sequences : CCDS (NCBI)AGRN
Cluster EST : UnigeneHs.602356 [ NCBI ]
CGAP (NCI)Hs.602356
Alternative Splicing : Fast-db (Paris)GSHG0000018
Alternative Splicing GalleryENSG00000188157
Gene ExpressionAGRN [ NCBI-GEO ]     AGRN [ SEEK ]   AGRN [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00468 (Uniprot)
NextProtO00468  [Medical]
With graphics : InterProO00468
Splice isoforms : SwissVarO00468 (Swissvar)
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_LAM_1 (PS01248)    EGF_LAM_2 (PS50027)    KAZAL_2 (PS51465)    LAM_G_DOMAIN (PS50025)    NTA (PS51121)    SEA (PS50024)   
Domains : Interpro (EBI)Agrin_NtA    ConA-like_lec_gl_sf    ConA-like_subgrp    EG-like_dom    EGF-like_CS    EGF_laminin    Fol_N    Kazal_dom    Laminin_G    SEA_dom    TIMP-like_OB-fold   
Related proteins : CluSTrO00468
Domain families : Pfam (Sanger)EGF (PF00008)    Kazal_1 (PF00050)    Kazal_2 (PF07648)    Laminin_EGF (PF00053)    Laminin_G_1 (PF00054)    NtA (PF03146)    SEA (PF01390)   
Domain families : Pfam (NCBI)pfam00008    pfam00050    pfam07648    pfam00053    pfam00054    pfam03146    pfam01390   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_Lam (SM00180)  FOLN (SM00274)  KAZAL (SM00280)  LamG (SM00282)  SEA (SM00200)  
DMDM Disease mutations375790
Blocks (Seattle)O00468
Human Protein AtlasENSG00000188157
Peptide AtlasO00468
HPRD10550
IPIIPI00374563   IPI00514026   IPI00976820   
Protein Interaction databases
DIP (DOE-UCLA)O00468
IntAct (EBI)O00468
FunCoupENSG00000188157
BioGRIDAGRN
InParanoidO00468
Interologous Interaction database O00468
IntegromeDBAGRN
STRING (EMBL)AGRN
Ontologies - Pathways
Ontology : AmiGOretinoid metabolic process  dystroglycan binding  structural constituent of cytoskeleton  calcium ion binding  protein binding  extracellular region  basal lamina  extracellular space  cytoplasm  Golgi lumen  plasma membrane  plasma membrane  carbohydrate metabolic process  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  plasma membrane organization  signal transduction  G-protein coupled acetylcholine receptor signaling pathway  axon guidance  neuromuscular junction development  phototransduction, visible light  cell surface  regulation of receptor activity  integral component of membrane  cell junction  extracellular matrix organization  glycosaminoglycan metabolic process  chondroitin sulfate metabolic process  acetylcholine receptor regulator activity  extracellular matrix  extracellular matrix  extracellular matrix  positive regulation of Rho GTPase activity  sialic acid binding  chondroitin sulfate binding  receptor clustering  receptor clustering  lysosomal lumen  laminin binding  heparan sulfate proteoglycan binding  positive regulation of neuron apoptotic process  small molecule metabolic process  clustering of voltage-gated sodium channels  synapse  neurotransmitter receptor metabolic process  positive regulation of synaptic growth at neuromuscular junction  positive regulation of transcription from RNA polymerase II promoter  synapse organization  positive regulation of filopodium assembly  extracellular vesicular exosome  
Ontology : EGO-EBIretinoid metabolic process  dystroglycan binding  structural constituent of cytoskeleton  calcium ion binding  protein binding  extracellular region  basal lamina  extracellular space  cytoplasm  Golgi lumen  plasma membrane  plasma membrane  carbohydrate metabolic process  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  plasma membrane organization  signal transduction  G-protein coupled acetylcholine receptor signaling pathway  axon guidance  neuromuscular junction development  phototransduction, visible light  cell surface  regulation of receptor activity  integral component of membrane  cell junction  extracellular matrix organization  glycosaminoglycan metabolic process  chondroitin sulfate metabolic process  acetylcholine receptor regulator activity  extracellular matrix  extracellular matrix  extracellular matrix  positive regulation of Rho GTPase activity  sialic acid binding  chondroitin sulfate binding  receptor clustering  receptor clustering  lysosomal lumen  laminin binding  heparan sulfate proteoglycan binding  positive regulation of neuron apoptotic process  small molecule metabolic process  clustering of voltage-gated sodium channels  synapse  neurotransmitter receptor metabolic process  positive regulation of synaptic growth at neuromuscular junction  positive regulation of transcription from RNA polymerase II promoter  synapse organization  positive regulation of filopodium assembly  extracellular vesicular exosome  
Pathways : BIOCARTAAgrin in Postsynaptic Differentiation [Genes]   
Pathways : KEGGECM-receptor interaction   
Protein Interaction DatabaseAGRN
Wikipedia pathwaysAGRN
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)AGRN
SNP (GeneSNP Utah)AGRN
SNP : HGBaseAGRN
Genetic variants : HAPMAPAGRN
1000_GenomesAGRN 
ICGC programENSG00000188157 
CONAN: Copy Number AnalysisAGRN 
Somatic Mutations in Cancer : COSMICAGRN 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDAGRN
OMIM103320    615120   
MedgenAGRN
GENETestsAGRN
Disease Genetic AssociationAGRN
Huge Navigator AGRN [HugePedia]  AGRN [HugeCancerGEM]
Genomic VariantsAGRN  AGRN [DGVbeta]
Exome VariantAGRN
dbVarAGRN
ClinVarAGRN
snp3D : Map Gene to Disease375790
General knowledge
Homologs : HomoloGeneAGRN
Homology/Alignments : Family Browser (UCSC)AGRN
Phylogenetic Trees/Animal Genes : TreeFamAGRN
Chemical/Protein Interactions : CTD375790
Chemical/Pharm GKB GenePA24626
Clinical trialAGRN
Cancer Resource (Charite)ENSG00000188157
Other databases
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
CoreMineAGRN
iHOPAGRN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:31:08 CEST 2014

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