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AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8))

Identity

Other namesANHU
SERPINA8
HGNC (Hugo) AGT
LocusID (NCBI) 183
Location 1q42.2
Location_base_pair Starts at 230838272 and ends at 230850336 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)AGT   333
Cards
Entrez_Gene (NCBI)AGT  183  angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
GeneCards (Weizmann)AGT
Ensembl (Hinxton)ENSG00000135744 [Gene_View]  chr1:230838272-230850336 [Contig_View]  AGT [Vega]
ICGC DataPortalENSG00000135744
AceView (NCBI)AGT
Genatlas (Paris)AGT
WikiGenes183
SOURCE (Princeton)NM_000029
Genomic and cartography
GoldenPath (UCSC)AGT  -  1q42.2   chr1:230838272-230850336 -  1q42.2   [Description]    (hg19-Feb_2009)
EnsemblAGT - 1q42.2 [CytoView]
Mapping of homologs : NCBIAGT [Mapview]
OMIM106150   145500   267430   
Gene and transcription
Genbank (Entrez)AB209769 AK222798 AK222815 AK293507 AK303755
RefSeq transcript (Entrez)NM_000029
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008836 NT_167186 NW_001838549 NW_004929294
Consensus coding sequences : CCDS (NCBI)AGT
Cluster EST : UnigeneHs.19383 [ NCBI ]
CGAP (NCI)Hs.19383
Alternative Splicing : Fast-db (Paris)GSHG0003033
Alternative Splicing GalleryENSG00000135744
Gene ExpressionAGT [ NCBI-GEO ]     AGT [ SEEK ]   AGT [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01019 (Uniprot)
NextProtP01019  [Medical]
With graphics : InterProP01019
Splice isoforms : SwissVarP01019 (Swissvar)
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Angiotensinogen    Serpin_CS    Serpin_dom    Serpin_fam   
Related proteins : CluSTrP01019
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM Disease mutations183
Blocks (Seattle)P01019
PDB (SRS)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    4AA1    4APH    4FYS   
PDB (PDBSum)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    4AA1    4APH    4FYS   
PDB (IMB)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    4AA1    4APH    4FYS   
PDB (RSDB)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    4AA1    4APH    4FYS   
Human Protein AtlasENSG00000135744
Peptide AtlasP01019
HPRD00106
IPIIPI00032220   IPI00908365   
Protein Interaction databases
DIP (DOE-UCLA)P01019
IntAct (EBI)P01019
FunCoupENSG00000135744
BioGRIDAGT
InParanoidP01019
Interologous Interaction database P01019
IntegromeDBAGT
STRING (EMBL)AGT
Ontologies - Pathways
Ontology : AmiGOovarian follicle rupture  regulation of cell growth  blood vessel development  branching involved in ureteric bud morphogenesis  positive regulation of cytokine production  kidney development  blood vessel remodeling  angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure  renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  angiotensin maturation  regulation of blood volume by renin-angiotensin  renin-angiotensin regulation of aldosterone production  regulation of renal output by angiotensin  regulation of blood vessel size by renin-angiotensin  renal system process  angiotensin-mediated drinking behavior  positive regulation of extracellular matrix constituent secretion  serine-type endopeptidase inhibitor activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  cellular sodium ion homeostasis  cell-matrix adhesion  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  activation of NF-kappaB-inducing kinase activity  nitric oxide mediated signal transduction  cell-cell signaling  aging  excretion  establishment of blood-nerve barrier  growth factor activity  negative regulation of cell proliferation  response to cold  response to salt stress  positive regulation of activation of JAK2 kinase activity  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  negative regulation of endopeptidase activity  regulation of norepinephrine secretion  positive regulation of phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  response to muscle activity involved in regulation of muscle adaptation  negative regulation of angiogenesis  regulation of vasoconstriction  regulation of proteolysis  extracellular matrix organization  negative regulation of cell growth  peristalsis  type 1 angiotensin receptor binding  type 2 angiotensin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  negative regulation of tissue remodeling  low-density lipoprotein particle remodeling  catenin import into nucleus  regulation of renal sodium excretion  positive regulation of renal sodium excretion  positive regulation of multicellular organism growth  regulation of cell proliferation  vasodilation  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  cellular lipid metabolic process  cellular protein metabolic process  small molecule metabolic process  positive regulation of fatty acid biosynthetic process  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of organ growth  astrocyte activation  fibroblast proliferation  positive regulation of fibroblast proliferation  regulation of long-term neuronal synaptic plasticity  smooth muscle cell proliferation  cytokine secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  smooth muscle cell differentiation  negative regulation of neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  regulation of calcium ion transport  cell growth involved in cardiac muscle cell development  positive regulation of protein tyrosine kinase activity  extracellular vesicular exosome  ERK1 and ERK2 cascade  uterine smooth muscle contraction  cellular response to mechanical stimulus  blood microparticle  positive regulation of branching involved in ureteric bud morphogenesis  positive regulation of reactive oxygen species metabolic process  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIovarian follicle rupture  regulation of cell growth  blood vessel development  branching involved in ureteric bud morphogenesis  positive regulation of cytokine production  kidney development  blood vessel remodeling  angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure  renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  angiotensin maturation  regulation of blood volume by renin-angiotensin  renin-angiotensin regulation of aldosterone production  regulation of renal output by angiotensin  regulation of blood vessel size by renin-angiotensin  renal system process  angiotensin-mediated drinking behavior  positive regulation of extracellular matrix constituent secretion  serine-type endopeptidase inhibitor activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  cellular sodium ion homeostasis  cell-matrix adhesion  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  activation of NF-kappaB-inducing kinase activity  nitric oxide mediated signal transduction  cell-cell signaling  aging  excretion  establishment of blood-nerve barrier  growth factor activity  negative regulation of cell proliferation  response to cold  response to salt stress  positive regulation of activation of JAK2 kinase activity  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  negative regulation of endopeptidase activity  regulation of norepinephrine secretion  positive regulation of phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  response to muscle activity involved in regulation of muscle adaptation  negative regulation of angiogenesis  regulation of vasoconstriction  regulation of proteolysis  extracellular matrix organization  negative regulation of cell growth  peristalsis  type 1 angiotensin receptor binding  type 2 angiotensin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  negative regulation of tissue remodeling  low-density lipoprotein particle remodeling  catenin import into nucleus  regulation of renal sodium excretion  positive regulation of renal sodium excretion  positive regulation of multicellular organism growth  regulation of cell proliferation  vasodilation  positive regulation of MAPK cascade  negative regulation of neuron apoptotic process  cellular lipid metabolic process  cellular protein metabolic process  small molecule metabolic process  positive regulation of fatty acid biosynthetic process  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription, DNA-templated  positive regulation of organ growth  astrocyte activation  fibroblast proliferation  positive regulation of fibroblast proliferation  regulation of long-term neuronal synaptic plasticity  smooth muscle cell proliferation  cytokine secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  smooth muscle cell differentiation  negative regulation of neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  regulation of calcium ion transport  cell growth involved in cardiac muscle cell development  positive regulation of protein tyrosine kinase activity  extracellular vesicular exosome  ERK1 and ERK2 cascade  uterine smooth muscle contraction  cellular response to mechanical stimulus  blood microparticle  positive regulation of branching involved in ureteric bud morphogenesis  positive regulation of reactive oxygen species metabolic process  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Angiotensin-converting enzyme 2 regulates heart function [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]   
Pathways : KEGGRenin-angiotensin system   
Protein Interaction DatabaseAGT
Wikipedia pathwaysAGT
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)AGT
SNP (GeneSNP Utah)AGT
SNP : HGBaseAGT
Genetic variants : HAPMAPAGT
1000_GenomesAGT 
ICGC programENSG00000135744 
CONAN: Copy Number AnalysisAGT 
Somatic Mutations in Cancer : COSMICAGT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDAGT
OMIM106150    145500    267430   
MedgenAGT
GENETestsAGT
Disease Genetic AssociationAGT
Huge Navigator AGT [HugePedia]  AGT [HugeCancerGEM]
Genomic VariantsAGT  AGT [DGVbeta]
Exome VariantAGT
dbVarAGT
ClinVarAGT
snp3D : Map Gene to Disease183
General knowledge
Homologs : HomoloGeneAGT
Homology/Alignments : Family Browser (UCSC)AGT
Phylogenetic Trees/Animal Genes : TreeFamAGT
Chemical/Protein Interactions : CTD183
Chemical/Pharm GKB GenePA42
Clinical trialAGT
Cancer Resource (Charite)ENSG00000135744
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineAGT
iHOPAGT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:31:09 CEST 2014

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