Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

AGT (angiotensinogen)

Identity

Other namesANHU
SERPINA8
HGNC (Hugo) AGT
LocusID (NCBI) 183
Atlas_Id 45772
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 230838272 and ends at 230850336 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGT (1q42.2) / CCNI2 (5q31.1)AGT (1q42.2) / GGCT (7p14.3)GABBR2 (9q22.33) / AGT (1q42.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AGT   333
Cards
Entrez_Gene (NCBI)AGT  183  angiotensinogen
AliasesANHU; SERPINA8
GeneCards (Weizmann)AGT
Ensembl hg19 (Hinxton)ENSG00000135744 [Gene_View]  chr1:230838272-230850336 [Contig_View]  AGT [Vega]
Ensembl hg38 (Hinxton)ENSG00000135744 [Gene_View]  chr1:230838272-230850336 [Contig_View]  AGT [Vega]
ICGC DataPortalENSG00000135744
TCGA cBioPortalAGT
AceView (NCBI)AGT
Genatlas (Paris)AGT
WikiGenes183
SOURCE (Princeton)AGT
Genomic and cartography
GoldenPath hg19 (UCSC)AGT  -     chr1:230838272-230850336 -  1q42.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)AGT  -     1q42.2   [Description]    (hg38-Dec_2013)
EnsemblAGT - 1q42.2 [CytoView hg19]  AGT - 1q42.2 [CytoView hg38]
Mapping of homologs : NCBIAGT [Mapview hg19]  AGT [Mapview hg38]
OMIM106150   145500   267430   
Gene and transcription
Genbank (Entrez)AB209769 AK222798 AK222815 AK293507 AK303755
RefSeq transcript (Entrez)NM_000029
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008836 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)AGT
Cluster EST : UnigeneHs.19383 [ NCBI ]
CGAP (NCI)Hs.19383
Alternative Splicing GalleryENSG00000135744
Gene ExpressionAGT [ NCBI-GEO ]   AGT [ EBI - ARRAY_EXPRESS ]   AGT [ SEEK ]   AGT [ MEM ]
Gene Expression Viewer (FireBrowse)AGT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)183
GTEX Portal (Tissue expression)AGT
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01019 (Uniprot)
NextProtP01019  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01019
Splice isoforms : SwissVarP01019 (Swissvar)
PhosPhoSitePlusP01019
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Angiotensinogen    Serpin_CS    Serpin_dom    Serpin_fam   
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM Disease mutations183
Blocks (Seattle)AGT
PDB (SRS)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
PDB (PDBSum)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
PDB (IMB)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
PDB (RSDB)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
Structural Biology KnowledgeBase1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
SCOP (Structural Classification of Proteins)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
CATH (Classification of proteins structures)1N9U    1N9V    2JP8    2WXW    2X0B    3CK0    3WOO    3WOR    4AA1    4APH    4FYS   
SuperfamilyP01019
Human Protein AtlasENSG00000135744
Peptide AtlasP01019
HPRD00106
IPIIPI00032220   IPI00908365   
Protein Interaction databases
DIP (DOE-UCLA)P01019
IntAct (EBI)P01019
FunCoupENSG00000135744
BioGRIDAGT
STRING (EMBL)AGT
ZODIACAGT
Ontologies - Pathways
QuickGOP01019
Ontology : AmiGOregulation of cell growth  positive regulation of cytokine production  kidney development  blood vessel remodeling  angiotensin maturation  regulation of blood volume by renin-angiotensin  renin-angiotensin regulation of aldosterone production  regulation of renal output by angiotensin  regulation of heart rate  regulation of blood vessel size by renin-angiotensin  renal system process  angiotensin-mediated drinking behavior  positive regulation of extracellular matrix constituent secretion  serine-type endopeptidase inhibitor activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  cytoplasm  cellular sodium ion homeostasis  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  nitric oxide mediated signal transduction  cell-cell signaling  female pregnancy  aging  growth factor activity  regulation of blood pressure  positive regulation of activation of JAK2 kinase activity  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  negative regulation of gene expression  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  negative regulation of endopeptidase activity  regulation of norepinephrine secretion  positive regulation of phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  response to muscle activity involved in regulation of muscle adaptation  superoxide-generating NADPH oxidase activator activity  negative regulation of angiogenesis  sodium channel regulator activity  regulation of vasoconstriction  negative regulation of cell growth  type 1 angiotensin receptor binding  type 2 angiotensin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  negative regulation of tissue remodeling  low-density lipoprotein particle remodeling  catenin import into nucleus  regulation of renal sodium excretion  positive regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  vasodilation  positive regulation of nitric oxide biosynthetic process  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of blood pressure  positive regulation of transcription, DNA-templated  positive regulation of vasodilation  receptor agonist activity  fibroblast proliferation  positive regulation of fibroblast proliferation  regulation of long-term neuronal synaptic plasticity  smooth muscle cell proliferation  cytokine secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  negative regulation of neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  regulation of calcium ion transport  regulation of transmission of nerve impulse  cell growth involved in cardiac muscle cell development  positive regulation of protein tyrosine kinase activity  extracellular exosome  ERK1 and ERK2 cascade  uterine smooth muscle contraction  cellular response to mechanical stimulus  blood microparticle  positive regulation of branching involved in ureteric bud morphogenesis  regulation of extracellular matrix assembly  positive regulation of membrane hyperpolarization  positive regulation of gap junction assembly  regulation of cardiac conduction  positive regulation of reactive oxygen species metabolic process  negative regulation of sodium ion transmembrane transporter activity  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIregulation of cell growth  positive regulation of cytokine production  kidney development  blood vessel remodeling  angiotensin maturation  regulation of blood volume by renin-angiotensin  renin-angiotensin regulation of aldosterone production  regulation of renal output by angiotensin  regulation of heart rate  regulation of blood vessel size by renin-angiotensin  renal system process  angiotensin-mediated drinking behavior  positive regulation of extracellular matrix constituent secretion  serine-type endopeptidase inhibitor activity  hormone activity  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  extracellular space  cytoplasm  cellular sodium ion homeostasis  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger  phospholipase C-activating G-protein coupled receptor signaling pathway  activation of phospholipase C activity  nitric oxide mediated signal transduction  cell-cell signaling  female pregnancy  aging  growth factor activity  regulation of blood pressure  positive regulation of activation of JAK2 kinase activity  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  negative regulation of gene expression  positive regulation of macrophage derived foam cell differentiation  positive regulation of cholesterol esterification  negative regulation of endopeptidase activity  regulation of norepinephrine secretion  positive regulation of phosphatidylinositol 3-kinase signaling  artery smooth muscle contraction  response to muscle activity involved in regulation of muscle adaptation  superoxide-generating NADPH oxidase activator activity  negative regulation of angiogenesis  sodium channel regulator activity  regulation of vasoconstriction  negative regulation of cell growth  type 1 angiotensin receptor binding  type 2 angiotensin receptor binding  positive regulation of cellular protein metabolic process  positive regulation of superoxide anion generation  positive regulation of NAD(P)H oxidase activity  negative regulation of tissue remodeling  low-density lipoprotein particle remodeling  catenin import into nucleus  regulation of renal sodium excretion  positive regulation of renal sodium excretion  angiotensin-activated signaling pathway  regulation of cell proliferation  vasodilation  positive regulation of nitric oxide biosynthetic process  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of blood pressure  positive regulation of transcription, DNA-templated  positive regulation of vasodilation  receptor agonist activity  fibroblast proliferation  positive regulation of fibroblast proliferation  regulation of long-term neuronal synaptic plasticity  smooth muscle cell proliferation  cytokine secretion  positive regulation of inflammatory response  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  negative regulation of neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  regulation of calcium ion transport  regulation of transmission of nerve impulse  cell growth involved in cardiac muscle cell development  positive regulation of protein tyrosine kinase activity  extracellular exosome  ERK1 and ERK2 cascade  uterine smooth muscle contraction  cellular response to mechanical stimulus  blood microparticle  positive regulation of branching involved in ureteric bud morphogenesis  regulation of extracellular matrix assembly  positive regulation of membrane hyperpolarization  positive regulation of gap junction assembly  regulation of cardiac conduction  positive regulation of reactive oxygen species metabolic process  negative regulation of sodium ion transmembrane transporter activity  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Angiotensin-converting enzyme 2 regulates heart function [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]   
Pathways : KEGGRenin-angiotensin system   
NDEx Network
Atlas of Cancer Signalling NetworkAGT
Wikipedia pathwaysAGT
Orthology - Evolution
OrthoDB183
GeneTree (enSembl)ENSG00000135744
Phylogenetic Trees/Animal Genes : TreeFamAGT
Homologs : HomoloGeneAGT
Homology/Alignments : Family Browser (UCSC)AGT
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerAGT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AGT
dbVarAGT
ClinVarAGT
1000_GenomesAGT 
Exome Variant ServerAGT
ExAC (Exome Aggregation Consortium)AGT (select the gene name)
Genetic variants : HAPMAP183
Genomic Variants (DGV)AGT [DGVbeta]
Mutations
ICGC Data PortalAGT 
TCGA Data PortalAGT 
Broad Tumor PortalAGT
OASIS PortalAGT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAGT 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AGT
DgiDB (Drug Gene Interaction Database)AGT
DoCM (Curated mutations)AGT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AGT (select a term)
intoGenAGT
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:230838272-230850336  ENSG00000135744
CONAN: Copy Number AnalysisAGT 
Mutations and Diseases : HGMDAGT
OMIM106150    145500    267430   
MedgenAGT
Genetic Testing Registry AGT
NextProtP01019 [Medical]
TSGene183
GENETestsAGT
Huge Navigator AGT [HugePedia]
snp3D : Map Gene to Disease183
BioCentury BCIQAGT
ClinGenAGT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD183
Chemical/Pharm GKB GenePA42
Clinical trialAGT
Miscellaneous
canSAR (ICR)AGT (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAGT
EVEXAGT
GoPubMedAGT
iHOPAGT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 18:58:36 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.