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AHCY (adenosylhomocysteinase)

Identity

Alias (NCBI)SAHH
adoHcyase
HGNC (Hugo) AHCY
HGNC Alias symbSAHH
HGNC Previous nameS-adenosylhomocysteine hydrolase
LocusID (NCBI) 191
Atlas_Id 50513
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34280268 and ends at 34303355 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AHCY (20q11.22) / DHPS (19p13.2)AHCY (20q11.22) / NPIPB7 (16q23.1)AHCY (20q11.22) / SRRM2 (16p13.3)
ITCH (20q11.22) / AHCY (20q11.22)LOC100507412 (-) / AHCY (20q11.22)TAX1BP1 (7p15.2) / AHCY (20q11.22)
ITCH 20q11.22 / AHCY 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)AHCY   343
Cards
Entrez_Gene (NCBI)AHCY    adenosylhomocysteinase
AliasesSAHH; adoHcyase
GeneCards (Weizmann)AHCY
Ensembl hg19 (Hinxton)ENSG00000101444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101444 [Gene_View]  ENSG00000101444 [Sequence]  chr20:34280268-34303355 [Contig_View]  AHCY [Vega]
ICGC DataPortalENSG00000101444
TCGA cBioPortalAHCY
AceView (NCBI)AHCY
Genatlas (Paris)AHCY
SOURCE (Princeton)AHCY
Genetics Home Reference (NIH)AHCY
Genomic and cartography
GoldenPath hg38 (UCSC)AHCY  -     chr20:34280268-34303355 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AHCY  -     20q11.22   [Description]    (hg19-Feb_2009)
GoldenPathAHCY - 20q11.22 [CytoView hg19]  AHCY - 20q11.22 [CytoView hg38]
ImmunoBaseENSG00000101444
Genome Data Viewer NCBIAHCY [Mapview hg19]  
OMIM180960   613752   
Gene and transcription
Genbank (Entrez)AI057366 AK097610 AK290422 AK300014 AK309204
RefSeq transcript (Entrez)NM_000687 NM_001161766 NM_001322084 NM_001322085 NM_001322086 NM_001362750
Consensus coding sequences : CCDS (NCBI)AHCY
Gene ExpressionAHCY [ NCBI-GEO ]   AHCY [ EBI - ARRAY_EXPRESS ]   AHCY [ SEEK ]   AHCY [ MEM ]
Gene Expression Viewer (FireBrowse)AHCY [ Firebrowse - Broad ]
GenevisibleExpression of AHCY in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)191
GTEX Portal (Tissue expression)AHCY
Human Protein AtlasENSG00000101444-AHCY [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23526   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23526  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23526
Catalytic activity : Enzyme3.3.1.1 [ Enzyme-Expasy ]   3.3.1.13.3.1.1 [ IntEnz-EBI ]   3.3.1.1 [ BRENDA ]   3.3.1.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP23526
Domaine pattern : Prosite (Expaxy)ADOHCYASE_1 (PS00738)    ADOHCYASE_2 (PS00739)   
Domains : Interpro (EBI)Adenosylhomocyst_ase-like_sf    Adenosylhomocysteinase-like    Ado_hCys_hydrolase_NAD-bd    NAD(P)-bd_dom_sf    S-Ado-L-homoCys_hydrolase_CS   
Domain families : Pfam (Sanger)AdoHcyase (PF05221)    AdoHcyase_NAD (PF00670)   
Domain families : Pfam (NCBI)pfam05221    pfam00670   
Domain families : Smart (EMBL)AdoHcyase (SM00996)  AdoHcyase_NAD (SM00997)  
Conserved Domain (NCBI)AHCY
PDB (RSDB)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
PDB Europe1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
PDB (PDBSum)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
PDB (IMB)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
Structural Biology KnowledgeBase1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
SCOP (Structural Classification of Proteins)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
CATH (Classification of proteins structures)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF    5W49    5W4B   
SuperfamilyP23526
AlphaFold pdb e-kbP23526   
Human Protein Atlas [tissue]ENSG00000101444-AHCY [tissue]
HPRD01621
Protein Interaction databases
DIP (DOE-UCLA)P23526
IntAct (EBI)P23526
BioGRIDAHCY
STRING (EMBL)AHCY
ZODIACAHCY
Ontologies - Pathways
QuickGOP23526
Ontology : AmiGOsulfur amino acid metabolic process  response to hypoxia  chronic inflammatory response to antigenic stimulus  adenosylhomocysteinase activity  adenosylhomocysteinase activity  protein binding  nucleus  cytosol  cytosol  cytosol  one-carbon metabolic process  response to nutrient  S-adenosylhomocysteine catabolic process  adenyl nucleotide binding  methylation  S-adenosylmethionine cycle  melanosome  circadian sleep/wake cycle  identical protein binding  neuron projection  NAD binding  extracellular exosome  
Ontology : EGO-EBIsulfur amino acid metabolic process  response to hypoxia  chronic inflammatory response to antigenic stimulus  adenosylhomocysteinase activity  adenosylhomocysteinase activity  protein binding  nucleus  cytosol  cytosol  cytosol  one-carbon metabolic process  response to nutrient  S-adenosylhomocysteine catabolic process  adenyl nucleotide binding  methylation  S-adenosylmethionine cycle  melanosome  circadian sleep/wake cycle  identical protein binding  neuron projection  NAD binding  extracellular exosome  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkAHCY
Atlas of Cancer Signalling NetworkAHCY
Wikipedia pathwaysAHCY
Orthology - Evolution
OrthoDB191
GeneTree (enSembl)ENSG00000101444
Phylogenetic Trees/Animal Genes : TreeFamAHCY
Homologs : HomoloGeneAHCY
Homology/Alignments : Family Browser (UCSC)AHCY
Gene fusions - Rearrangements
Fusion : MitelmanITCH/AHCY [20q11.22/20q11.22]  
Fusion : MitelmanTAX1BP1/AHCY [7p15.2/20q11.22]  
Fusion : QuiverAHCY
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAHCY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AHCY
dbVarAHCY
ClinVarAHCY
MonarchAHCY
1000_GenomesAHCY 
Exome Variant ServerAHCY
GNOMAD BrowserENSG00000101444
Varsome BrowserAHCY
ACMGAHCY variants
VarityP23526
Genomic Variants (DGV)AHCY [DGVbeta]
DECIPHERAHCY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAHCY 
Mutations
ICGC Data PortalAHCY 
TCGA Data PortalAHCY 
Broad Tumor PortalAHCY
OASIS PortalAHCY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAHCY  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DAHCY
Mutations and Diseases : HGMDAHCY
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaAHCY
DgiDB (Drug Gene Interaction Database)AHCY
DoCM (Curated mutations)AHCY
CIViC (Clinical Interpretations of Variants in Cancer)AHCY
Cancer3DAHCY
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180960    613752   
Orphanet11805   
DisGeNETAHCY
MedgenAHCY
Genetic Testing Registry AHCY
NextProtP23526 [Medical]
GENETestsAHCY
Target ValidationAHCY
Huge Navigator AHCY [HugePedia]
ClinGenAHCY
Clinical trials, drugs, therapy
MyCancerGenomeAHCY
Protein Interactions : CTDAHCY
Pharm GKB GenePA24636
PharosP23526
Clinical trialAHCY
Miscellaneous
canSAR (ICR)AHCY
HarmonizomeAHCY
DataMed IndexAHCY
Probes
Litterature
PubMed139 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXAHCY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:58:52 CEST 2021

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