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AHCY (adenosylhomocysteinase)

Identity

Alias_namesS-adenosylhomocysteine hydrolase
Alias_symbol (synonym)SAHH
Other aliasadoHcyase
HGNC (Hugo) AHCY
LocusID (NCBI) 191
Atlas_Id 50513
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34280265 and ends at 34303511 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AHCY (20q11.22) / DHPS (19p13.2)AHCY (20q11.22) / NPIPB7 (16q23.1)AHCY (20q11.22) / SRRM2 (16p13.3)
ITCH (20q11.22) / AHCY (20q11.22)LOC100507412 (-) / AHCY (20q11.22)TAX1BP1 (7p15.2) / AHCY (20q11.22)
ITCH 20q11.22 / AHCY 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AHCY   343
Cards
Entrez_Gene (NCBI)AHCY  191  adenosylhomocysteinase
AliasesSAHH; adoHcyase
GeneCards (Weizmann)AHCY
Ensembl hg19 (Hinxton)ENSG00000101444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101444 [Gene_View]  chr20:34280265-34303511 [Contig_View]  AHCY [Vega]
ICGC DataPortalENSG00000101444
TCGA cBioPortalAHCY
AceView (NCBI)AHCY
Genatlas (Paris)AHCY
WikiGenes191
SOURCE (Princeton)AHCY
Genetics Home Reference (NIH)AHCY
Genomic and cartography
GoldenPath hg38 (UCSC)AHCY  -     chr20:34280265-34303511 -  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AHCY  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblAHCY - 20q11.22 [CytoView hg19]  AHCY - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIAHCY [Mapview hg19]  AHCY [Mapview hg38]
OMIM180960   613752   
Gene and transcription
Genbank (Entrez)AI057366 AK097610 AK290422 AK300014 AK309204
RefSeq transcript (Entrez)NM_000687 NM_001161766 NM_001322084 NM_001322085 NM_001322086
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AHCY
Cluster EST : UnigeneHs.388004 [ NCBI ]
CGAP (NCI)Hs.388004
Alternative Splicing GalleryENSG00000101444
Gene ExpressionAHCY [ NCBI-GEO ]   AHCY [ EBI - ARRAY_EXPRESS ]   AHCY [ SEEK ]   AHCY [ MEM ]
Gene Expression Viewer (FireBrowse)AHCY [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)191
GTEX Portal (Tissue expression)AHCY
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23526   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23526  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23526
Splice isoforms : SwissVarP23526
Catalytic activity : Enzyme3.3.1.1 [ Enzyme-Expasy ]   3.3.1.13.3.1.1 [ IntEnz-EBI ]   3.3.1.1 [ BRENDA ]   3.3.1.1 [ KEGG ]   
PhosPhoSitePlusP23526
Domaine pattern : Prosite (Expaxy)ADOHCYASE_1 (PS00738)    ADOHCYASE_2 (PS00739)   
Domains : Interpro (EBI)Adenosylhomocysteinase-like    Ado_hCys_hydrolase_NAD-bd    NAD(P)-bd_dom    S-Ado-L-homoCys_hydrolase_CS   
Domain families : Pfam (Sanger)AdoHcyase (PF05221)    AdoHcyase_NAD (PF00670)   
Domain families : Pfam (NCBI)pfam05221    pfam00670   
Domain families : Smart (EMBL)AdoHcyase (SM00996)  AdoHcyase_NAD (SM00997)  
Conserved Domain (NCBI)AHCY
DMDM Disease mutations191
Blocks (Seattle)AHCY
PDB (SRS)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
PDB (PDBSum)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
PDB (IMB)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
PDB (RSDB)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
Structural Biology KnowledgeBase1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
SCOP (Structural Classification of Proteins)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
CATH (Classification of proteins structures)1A7A    1LI4    3NJ4    4PFJ    4PGF    4YVF   
SuperfamilyP23526
Human Protein AtlasENSG00000101444
Peptide AtlasP23526
HPRD01621
IPIIPI00012007   IPI00935818   
Protein Interaction databases
DIP (DOE-UCLA)P23526
IntAct (EBI)P23526
FunCoupENSG00000101444
BioGRIDAHCY
STRING (EMBL)AHCY
ZODIACAHCY
Ontologies - Pathways
QuickGOP23526
Ontology : AmiGOsulfur amino acid metabolic process  response to hypoxia  chronic inflammatory response to antigenic stimulus  adenosylhomocysteinase activity  protein binding  nucleus  cytosol  cytosol  cytosol  one-carbon metabolic process  response to nutrient  S-adenosylhomocysteine catabolic process  adenyl nucleotide binding  methylation  S-adenosylmethionine cycle  melanosome  circadian sleep/wake cycle  identical protein binding  neuron projection  NAD binding  extracellular exosome  homocysteine biosynthetic process  
Ontology : EGO-EBIsulfur amino acid metabolic process  response to hypoxia  chronic inflammatory response to antigenic stimulus  adenosylhomocysteinase activity  protein binding  nucleus  cytosol  cytosol  cytosol  one-carbon metabolic process  response to nutrient  S-adenosylhomocysteine catabolic process  adenyl nucleotide binding  methylation  S-adenosylmethionine cycle  melanosome  circadian sleep/wake cycle  identical protein binding  neuron projection  NAD binding  extracellular exosome  homocysteine biosynthetic process  
Pathways : KEGGCysteine and methionine metabolism   
NDEx NetworkAHCY
Atlas of Cancer Signalling NetworkAHCY
Wikipedia pathwaysAHCY
Orthology - Evolution
OrthoDB191
GeneTree (enSembl)ENSG00000101444
Phylogenetic Trees/Animal Genes : TreeFamAHCY
HOVERGENP23526
HOGENOMP23526
Homologs : HomoloGeneAHCY
Homology/Alignments : Family Browser (UCSC)AHCY
Gene fusions - Rearrangements
Fusion : MitelmanITCH/AHCY [20q11.22/20q11.22]  [t(20;20)(q11;q11)]  
Fusion : MitelmanTAX1BP1/AHCY [7p15.2/20q11.22]  [t(7;20)(p15;q11)]  
Fusion: TCGAITCH 20q11.22 AHCY 20q11.22 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAHCY [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AHCY
dbVarAHCY
ClinVarAHCY
1000_GenomesAHCY 
Exome Variant ServerAHCY
ExAC (Exome Aggregation Consortium)AHCY (select the gene name)
Genetic variants : HAPMAP191
Genomic Variants (DGV)AHCY [DGVbeta]
DECIPHERAHCY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAHCY 
Mutations
ICGC Data PortalAHCY 
TCGA Data PortalAHCY 
Broad Tumor PortalAHCY
OASIS PortalAHCY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAHCY  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAHCY
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch AHCY
DgiDB (Drug Gene Interaction Database)AHCY
DoCM (Curated mutations)AHCY (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AHCY (select a term)
intoGenAHCY
Cancer3DAHCY(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180960    613752   
Orphanet11805   
MedgenAHCY
Genetic Testing Registry AHCY
NextProtP23526 [Medical]
TSGene191
GENETestsAHCY
Target ValidationAHCY
Huge Navigator AHCY [HugePedia]
snp3D : Map Gene to Disease191
BioCentury BCIQAHCY
ClinGenAHCY
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD191
Chemical/Pharm GKB GenePA24636
Clinical trialAHCY
Miscellaneous
canSAR (ICR)AHCY (select the gene name)
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAHCY
EVEXAHCY
GoPubMedAHCY
iHOPAHCY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:56:38 CEST 2017

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