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ALKBH4 (alkB homolog 4, lysine demethylase)

Identity

Alias_namesalkB
Alias_symbol (synonym)FLJ20013
Other aliasABH4
HGNC (Hugo) ALKBH4
LocusID (NCBI) 54784
Atlas_Id 43078
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 102096667 and ends at 102105321 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ALKBH4   21900
Cards
Entrez_Gene (NCBI)ALKBH4  54784  alkB homolog 4, lysine demethylase
AliasesABH4
GeneCards (Weizmann)ALKBH4
Ensembl hg19 (Hinxton)ENSG00000160993 [Gene_View]  chr7:102096667-102105321 [Contig_View]  ALKBH4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160993 [Gene_View]  chr7:102096667-102105321 [Contig_View]  ALKBH4 [Vega]
ICGC DataPortalENSG00000160993
TCGA cBioPortalALKBH4
AceView (NCBI)ALKBH4
Genatlas (Paris)ALKBH4
WikiGenes54784
SOURCE (Princeton)ALKBH4
Genetics Home Reference (NIH)ALKBH4
Genomic and cartography
GoldenPath hg19 (UCSC)ALKBH4  -     chr7:102096667-102105321 -  7q22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ALKBH4  -     7q22.1   [Description]    (hg38-Dec_2013)
EnsemblALKBH4 - 7q22.1 [CytoView hg19]  ALKBH4 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBIALKBH4 [Mapview hg19]  ALKBH4 [Mapview hg38]
OMIM613302   
Gene and transcription
Genbank (Entrez)AK000020 AK026097 AK222689 BC002820 BC017096
RefSeq transcript (Entrez)NM_017621
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)ALKBH4
Cluster EST : UnigeneHs.658598 [ NCBI ]
CGAP (NCI)Hs.658598
Alternative Splicing GalleryENSG00000160993
Gene ExpressionALKBH4 [ NCBI-GEO ]   ALKBH4 [ EBI - ARRAY_EXPRESS ]   ALKBH4 [ SEEK ]   ALKBH4 [ MEM ]
Gene Expression Viewer (FireBrowse)ALKBH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54784
GTEX Portal (Tissue expression)ALKBH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NXW9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NXW9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NXW9
Splice isoforms : SwissVarQ9NXW9
Catalytic activity : Enzyme1.14.11.- [ Enzyme-Expasy ]   1.14.11.-1.14.11.- [ IntEnz-EBI ]   1.14.11.- [ BRENDA ]   1.14.11.- [ KEGG ]   
PhosPhoSitePlusQ9NXW9
Domains : Interpro (EBI)AlkB-like    ALKBH4   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)ALKBH4
DMDM Disease mutations54784
Blocks (Seattle)ALKBH4
SuperfamilyQ9NXW9
Human Protein AtlasENSG00000160993
Peptide AtlasQ9NXW9
HPRD07875
IPIIPI00033770   IPI00759604   
Protein Interaction databases
DIP (DOE-UCLA)Q9NXW9
IntAct (EBI)Q9NXW9
FunCoupENSG00000160993
BioGRIDALKBH4
STRING (EMBL)ALKBH4
ZODIACALKBH4
Ontologies - Pathways
QuickGOQ9NXW9
Ontology : AmiGOactin binding  protein binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  protein demethylation  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  midbody  actomyosin structure organization  demethylase activity  cleavage furrow ingression  metal ion binding  oxidation-reduction process  contractile ring  
Ontology : EGO-EBIactin binding  protein binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  protein demethylation  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  midbody  actomyosin structure organization  demethylase activity  cleavage furrow ingression  metal ion binding  oxidation-reduction process  contractile ring  
NDEx NetworkALKBH4
Atlas of Cancer Signalling NetworkALKBH4
Wikipedia pathwaysALKBH4
Orthology - Evolution
OrthoDB54784
GeneTree (enSembl)ENSG00000160993
Phylogenetic Trees/Animal Genes : TreeFamALKBH4
HOVERGENQ9NXW9
HOGENOMQ9NXW9
Homologs : HomoloGeneALKBH4
Homology/Alignments : Family Browser (UCSC)ALKBH4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerALKBH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ALKBH4
dbVarALKBH4
ClinVarALKBH4
1000_GenomesALKBH4 
Exome Variant ServerALKBH4
ExAC (Exome Aggregation Consortium)ALKBH4 (select the gene name)
Genetic variants : HAPMAP54784
Genomic Variants (DGV)ALKBH4 [DGVbeta]
DECIPHER (Syndromes)7:102096667-102105321  ENSG00000160993
CONAN: Copy Number AnalysisALKBH4 
Mutations
ICGC Data PortalALKBH4 
TCGA Data PortalALKBH4 
Broad Tumor PortalALKBH4
OASIS PortalALKBH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICALKBH4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDALKBH4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ALKBH4
DgiDB (Drug Gene Interaction Database)ALKBH4
DoCM (Curated mutations)ALKBH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ALKBH4 (select a term)
intoGenALKBH4
Cancer3DALKBH4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613302   
Orphanet
MedgenALKBH4
Genetic Testing Registry ALKBH4
NextProtQ9NXW9 [Medical]
TSGene54784
GENETestsALKBH4
Huge Navigator ALKBH4 [HugePedia]
snp3D : Map Gene to Disease54784
BioCentury BCIQALKBH4
ClinGenALKBH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54784
Chemical/Pharm GKB GenePA143485294
Clinical trialALKBH4
Miscellaneous
canSAR (ICR)ALKBH4 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineALKBH4
EVEXALKBH4
GoPubMedALKBH4
iHOPALKBH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:52:11 CEST 2017

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