ANGPT4 (angiopoietin 4)

2003-05-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
ANG3,ANG4

Other Information

Locus ID:

NCBI: 51378
MIM: 603705
HGNC: 487
Ensembl: ENSG00000101280

Variants:

dbSNP: 51378
ClinVar: 51378
TCGA: ENSG00000101280
COSMIC: ANGPT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101280ENST00000381922Q9Y264

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Tie2 SignalingREACTOMER-HSA-210993

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
152842202004Biological characterization of angiopoietin-3 and angiopoietin-4.40
222677462012Angiopoietin-like 4 (Angptl4) protein is a physiological mediator of intracellular lipolysis in murine adipocytes.40
208231542010Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis.25
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
151989272004Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis.15
216036282011Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2.14
167900852006Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

ANGPT4 (angiopoietin 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/638/angpt4