ANKK1 (ankyrin repeat and kinase domain containing 1)

2006-10-01  

Identity

HGNC
LOCATION
11q23.2
LOCUSID
ALIAS
PKK2,sgK288

Other Information

Locus ID:

NCBI: 255239
MIM: 608774
HGNC: 21027
Ensembl: ENSG00000170209

Variants:

dbSNP: 255239
ClinVar: 255239
TCGA: ENSG00000170209
COSMIC: ANKK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170209ENST00000303941Q8NFD2
ENSG00000170209ENST00000542948H0YH32

Expression (GTEx)

0
1
2
3
4
5
6
7

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD18855532, 18926547
PA128406954Weight gainDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA151186253nemonaprideChemicalClinicalAnnotationassociatedPD10823405
PA164712720Drugs used in nicotine dependenceChemicalClinicalAnnotation, VariantAnnotationambiguousPD15077009, 19273465, 21540761
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 27447243, 8033754
PA444065EpilepsyDiseaseClinicalAnnotationassociatedPD
PA444460Heroin DependenceDiseaseClinicalAnnotationassociatedPD23651024
PA444545HyperprolactinemiaDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA445043Opioid-Related DisordersDiseaseClinicalAnnotationassociatedPD11054774, 23651024, 25500252
PA445048NauseaDiseaseClinicalAnnotationassociatedPD24360851
PA445876Tobacco Use DisorderDiseaseClinicalAnnotation, VariantAnnotationambiguousPD14570538, 15077009, 15492764, 17654295, 18058343, 19273465, 21540761, 25881752, 26153084
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociatedPD23635803
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD10823405, 18855532, 18926547
PA447268tardive dyskinesiaDiseaseClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA448073ethanolChemicalClinicalAnnotationassociatedPD10490697, 11054774, 17989061, 1839129, 1969501, 1979357, 27447243, 8033754
PA448687bupropionChemicalClinicalAnnotationassociatedPD14570538, 15492764, 17654295, 18058343, 25881752, 26153084
PA449061clozapineChemicalClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23851570, 23859574, 26872113
PA449376disulfiramChemicalClinicalAnnotationassociatedPD23635803
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437
PA450401methadoneChemicalClinicalAnnotationassociatedPD23651024
PA450626nicotineChemicalClinicalAnnotationassociatedPD15077009, 19273465, 21540761
PA450688olanzapineChemicalClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 20714340, 23559402, 23851570, 23859574, 26872113
PA451114prochlorperazineChemicalClinicalAnnotationassociatedPD24360851
PA451257risperidoneChemicalClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 18855532, 18926547, 20714340, 23851570, 23859574, 26872113
PA451846valproic acidChemicalClinicalAnnotationassociatedPD
PA452233antipsychoticsChemicalClinicalAnnotationassociatedPD17767146, 18086475, 18180754, 18579277, 18855532, 18926547, 20714340, 23851570, 23859574, 26872113
PA452618opioidsChemicalClinicalAnnotationassociatedPD11054774, 25500252

References

Pubmed IDYearTitleCitations
189273952008Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele.297
170854842006Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.82
193217662009Dopamine DRD2 polymorphism alters reversal learning and associated neural activity.77
174530612007Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias.75
178506422007Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.58
178506422007Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1.58
183543872009Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.57
183543872009Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample.57
177616872007Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.51
177616872007Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.51

Citation

Dessen P

ANKK1 (ankyrin repeat and kinase domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43121/ankk1