Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1)

Identity

Alias_namesKIAA0317
KIAA0317
Alias_symbol (synonym)FIEL1
Other alias
HGNC (Hugo) AREL1
LocusID (NCBI) 9870
Atlas_Id 60454
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 74661252 and ends at 74713104 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AREL1 (14q24.3) / AREL1 (14q24.3)AREL1 (14q24.3) / SRPK2 (7q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)AREL1   20363
Cards
Entrez_Gene (NCBI)AREL1  9870  apoptosis resistant E3 ubiquitin protein ligase 1
AliasesFIEL1; KIAA0317
GeneCards (Weizmann)AREL1
Ensembl hg19 (Hinxton)ENSG00000119682 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000119682 [Gene_View]  chr14:74661252-74713104 [Contig_View]  AREL1 [Vega]
ICGC DataPortalENSG00000119682
TCGA cBioPortalAREL1
AceView (NCBI)AREL1
Genatlas (Paris)AREL1
WikiGenes9870
SOURCE (Princeton)AREL1
Genetics Home Reference (NIH)AREL1
Genomic and cartography
GoldenPath hg38 (UCSC)AREL1  -     chr14:74661252-74713104 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)AREL1  -     14q24.3   [Description]    (hg19-Feb_2009)
EnsemblAREL1 - 14q24.3 [CytoView hg19]  AREL1 - 14q24.3 [CytoView hg38]
Mapping of homologs : NCBIAREL1 [Mapview hg19]  AREL1 [Mapview hg38]
OMIM615380   
Gene and transcription
Genbank (Entrez)AB002315 AK296912 AK304217 BC032944 BI459956
RefSeq transcript (Entrez)NM_001039479 NM_014821
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)AREL1
Cluster EST : UnigeneHs.497417 [ NCBI ]
CGAP (NCI)Hs.497417
Alternative Splicing GalleryENSG00000119682
Gene ExpressionAREL1 [ NCBI-GEO ]   AREL1 [ EBI - ARRAY_EXPRESS ]   AREL1 [ SEEK ]   AREL1 [ MEM ]
Gene Expression Viewer (FireBrowse)AREL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9870
GTEX Portal (Tissue expression)AREL1
Human Protein AtlasENSG00000119682-AREL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15033   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15033  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15033
Splice isoforms : SwissVarO15033
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusO15033
Domaine pattern : Prosite (Expaxy)FILAMIN_REPEAT (PS50194)    HECT (PS50237)   
Domains : Interpro (EBI)Filamin/ABP280_repeat-like    HECT_dom    Ig-like_fold    Ig_E-set   
Domain families : Pfam (Sanger)Filamin (PF00630)    HECT (PF00632)   
Domain families : Pfam (NCBI)pfam00630    pfam00632   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)AREL1
DMDM Disease mutations9870
Blocks (Seattle)AREL1
SuperfamilyO15033
Human Protein Atlas [tissue]ENSG00000119682-AREL1 [tissue]
Peptide AtlasO15033
HPRD13794
IPIIPI00006561   IPI00472646   IPI01025154   IPI00384136   IPI01024791   IPI01024923   IPI01026434   IPI01026546   IPI01026524   IPI01026187   IPI01025949   
Protein Interaction databases
DIP (DOE-UCLA)O15033
IntAct (EBI)O15033
FunCoupENSG00000119682
BioGRIDAREL1
STRING (EMBL)AREL1
ZODIACAREL1
Ontologies - Pathways
QuickGOO15033
Ontology : AmiGOubiquitin-protein transferase activity  cytosol  apoptotic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of apoptotic process  
Ontology : EGO-EBIubiquitin-protein transferase activity  cytosol  apoptotic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of apoptotic process  
NDEx NetworkAREL1
Atlas of Cancer Signalling NetworkAREL1
Wikipedia pathwaysAREL1
Orthology - Evolution
OrthoDB9870
GeneTree (enSembl)ENSG00000119682
Phylogenetic Trees/Animal Genes : TreeFamAREL1
HOVERGENO15033
HOGENOMO15033
Homologs : HomoloGeneAREL1
Homology/Alignments : Family Browser (UCSC)AREL1
Gene fusions - Rearrangements
Tumor Fusion PortalAREL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAREL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)AREL1
dbVarAREL1
ClinVarAREL1
1000_GenomesAREL1 
Exome Variant ServerAREL1
ExAC (Exome Aggregation Consortium)ENSG00000119682
GNOMAD BrowserENSG00000119682
Genetic variants : HAPMAP9870
Genomic Variants (DGV)AREL1 [DGVbeta]
DECIPHERAREL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAREL1 
Mutations
ICGC Data PortalAREL1 
TCGA Data PortalAREL1 
Broad Tumor PortalAREL1
OASIS PortalAREL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDAREL1
BioMutasearch AREL1
DgiDB (Drug Gene Interaction Database)AREL1
DoCM (Curated mutations)AREL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)AREL1 (select a term)
intoGenAREL1
Cancer3DAREL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615380   
Orphanet
DisGeNETAREL1
MedgenAREL1
Genetic Testing Registry AREL1
NextProtO15033 [Medical]
TSGene9870
GENETestsAREL1
Target ValidationAREL1
Huge Navigator AREL1 [HugePedia]
snp3D : Map Gene to Disease9870
BioCentury BCIQAREL1
ClinGenAREL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9870
Chemical/Pharm GKB GenePA134985474
Clinical trialAREL1
Miscellaneous
canSAR (ICR)AREL1 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAREL1
EVEXAREL1
GoPubMedAREL1
iHOPAREL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:29:13 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.