ARHGAP4 (Rho GTPase activating protein 4)

2003-05-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
C1,RGC1,RhoGAP4,SrGAP4,p115
FUSION GENES

Other Information

Locus ID:

NCBI: 393
MIM: 300023
HGNC: 674
Ensembl: ENSG00000089820

Variants:

dbSNP: 393
ClinVar: 393
TCGA: ENSG00000089820
COSMIC: ARHGAP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089820ENST00000350060P98171
ENSG00000089820ENST00000370016E7EQN5
ENSG00000089820ENST00000370028P98171
ENSG00000089820ENST00000393721E9PCM6
ENSG00000089820ENST00000404127F8WAR0
ENSG00000089820ENST00000418750H7C3G3
ENSG00000089820ENST00000420383A0A0B4J1X7
ENSG00000089820ENST00000422091C9JLA8
ENSG00000089820ENST00000422918H7C120
ENSG00000089820ENST00000442172H7C2Z8
ENSG00000089820ENST00000442262C9J5M2
ENSG00000089820ENST00000454164H7C3K8
ENSG00000089820ENST00000461052S4R314
ENSG00000089820ENST00000488269S4R352

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
220097492011PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.17
240438782014Common variants on Xq28 conferring risk of schizophrenia in Han Chinese.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
229659142012A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability.7
117541002002Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus.6
127367242003FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains.3
309585312019ARHGAP4 regulates the cell migration and invasion of pancreatic cancer by the HDAC2/β-catenin signaling pathway.2
184897902008Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes.1

Citation

Dessen P

ARHGAP4 (Rho GTPase activating protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/696/arhgap4