Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARHGAP4 (Rho GTPase activating protein 4)

Identity

Alias_symbol (synonym)KIAA0131
C1
p115
RhoGAP4
SrGAP4
Other aliasRGC1
HGNC (Hugo) ARHGAP4
LocusID (NCBI) 393
Atlas_Id 696
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153907376 and ends at 153926260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP4 (Xq28) / ARHGAP4 (Xq28)ARHGAP4 (Xq28) / RENBP (Xq28)ARHGAP4 (Xq28) / TEX28 (Xq28)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP4   674
Cards
Entrez_Gene (NCBI)ARHGAP4  393  Rho GTPase activating protein 4
AliasesC1; RGC1; RhoGAP4; SrGAP4; 
p115
GeneCards (Weizmann)ARHGAP4
Ensembl hg19 (Hinxton)ENSG00000089820 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089820 [Gene_View]  chrX:153907376-153926260 [Contig_View]  ARHGAP4 [Vega]
ICGC DataPortalENSG00000089820
TCGA cBioPortalARHGAP4
AceView (NCBI)ARHGAP4
Genatlas (Paris)ARHGAP4
WikiGenes393
SOURCE (Princeton)ARHGAP4
Genetics Home Reference (NIH)ARHGAP4
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP4  -     chrX:153907376-153926260 -  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP4  -     Xq28   [Description]    (hg19-Feb_2009)
EnsemblARHGAP4 - Xq28 [CytoView hg19]  ARHGAP4 - Xq28 [CytoView hg38]
Mapping of homologs : NCBIARHGAP4 [Mapview hg19]  ARHGAP4 [Mapview hg38]
OMIM300023   
Gene and transcription
Genbank (Entrez)AI249937 AK294562 AM392626 AM393222 AY183123
RefSeq transcript (Entrez)NM_001164741 NM_001666
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP4
Cluster EST : UnigeneHs.701324 [ NCBI ]
CGAP (NCI)Hs.701324
Alternative Splicing GalleryENSG00000089820
Gene ExpressionARHGAP4 [ NCBI-GEO ]   ARHGAP4 [ EBI - ARRAY_EXPRESS ]   ARHGAP4 [ SEEK ]   ARHGAP4 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)393
GTEX Portal (Tissue expression)ARHGAP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP98171   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP98171  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP98171
Splice isoforms : SwissVarP98171
PhosPhoSitePlusP98171
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)F_BAR    FCH_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SH3_domain   
Domain families : Pfam (Sanger)FCH (PF00611)    RhoGAP (PF00620)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00611    pfam00620    pfam00018   
Domain families : Smart (EMBL)FCH (SM00055)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGAP4
DMDM Disease mutations393
Blocks (Seattle)ARHGAP4
PDB (SRS)2EPD   
PDB (PDBSum)2EPD   
PDB (IMB)2EPD   
PDB (RSDB)2EPD   
Structural Biology KnowledgeBase2EPD   
SCOP (Structural Classification of Proteins)2EPD   
CATH (Classification of proteins structures)2EPD   
SuperfamilyP98171
Human Protein AtlasENSG00000089820
Peptide AtlasP98171
HPRD02063
IPIIPI00398854   IPI00328842   IPI00640371   IPI00642835   IPI00852936   IPI00852774   IPI00852808   IPI00852636   IPI00852716   IPI00878366   IPI00878617   IPI00878758   
Protein Interaction databases
DIP (DOE-UCLA)P98171
IntAct (EBI)P98171
FunCoupENSG00000089820
BioGRIDARHGAP4
STRING (EMBL)ARHGAP4
ZODIACARHGAP4
Ontologies - Pathways
QuickGOP98171
Ontology : AmiGOSH3/SH2 adaptor activity  GTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  microtubule  cytoskeleton organization  Rho protein signal transduction  positive regulation of signal transduction  negative regulation of fibroblast migration  negative regulation of cell migration  growth cone  negative regulation of axon extension  positive regulation of GTPase activity  Rac GTPase binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBISH3/SH2 adaptor activity  GTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytoplasm  Golgi apparatus  cytosol  microtubule  cytoskeleton organization  Rho protein signal transduction  positive regulation of signal transduction  negative regulation of fibroblast migration  negative regulation of cell migration  growth cone  negative regulation of axon extension  positive regulation of GTPase activity  Rac GTPase binding  regulation of small GTPase mediated signal transduction  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]   
NDEx NetworkARHGAP4
Atlas of Cancer Signalling NetworkARHGAP4
Wikipedia pathwaysARHGAP4
Orthology - Evolution
OrthoDB393
GeneTree (enSembl)ENSG00000089820
Phylogenetic Trees/Animal Genes : TreeFamARHGAP4
HOVERGENP98171
HOGENOMP98171
Homologs : HomoloGeneARHGAP4
Homology/Alignments : Family Browser (UCSC)ARHGAP4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP4
dbVarARHGAP4
ClinVarARHGAP4
1000_GenomesARHGAP4 
Exome Variant ServerARHGAP4
ExAC (Exome Aggregation Consortium)ARHGAP4 (select the gene name)
Genetic variants : HAPMAP393
Genomic Variants (DGV)ARHGAP4 [DGVbeta]
DECIPHERARHGAP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP4 
Mutations
ICGC Data PortalARHGAP4 
TCGA Data PortalARHGAP4 
Broad Tumor PortalARHGAP4
OASIS PortalARHGAP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARHGAP4
DgiDB (Drug Gene Interaction Database)ARHGAP4
DoCM (Curated mutations)ARHGAP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP4 (select a term)
intoGenARHGAP4
Cancer3DARHGAP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300023   
Orphanet
MedgenARHGAP4
Genetic Testing Registry ARHGAP4
NextProtP98171 [Medical]
TSGene393
GENETestsARHGAP4
Target ValidationARHGAP4
Huge Navigator ARHGAP4 [HugePedia]
snp3D : Map Gene to Disease393
BioCentury BCIQARHGAP4
ClinGenARHGAP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD393
Chemical/Pharm GKB GenePA24958
Clinical trialARHGAP4
Miscellaneous
canSAR (ICR)ARHGAP4 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP4
EVEXARHGAP4
GoPubMedARHGAP4
iHOPARHGAP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:57:54 CEST 2017

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