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ARHGEF10 (Rho guanine nucleotide exchange factor 10)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 10
Alias_symbol (synonym)KIAA0294
Gef10
Other aliasGEF10
SNCV
HGNC (Hugo) ARHGEF10
LocusID (NCBI) 9639
Atlas_Id 43144
Location 8p23.3  [Link to chromosome band 8p23]
Location_base_pair Starts at 1823976 and ends at 1958641 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Domain families : Pfam (NCBI)
Nomenclature
HGNC (Hugo)ARHGEF10   14103
LRG (Locus Reference Genomic)LRG_234
Cards
Entrez_Gene (NCBI)ARHGEF10  9639  Rho guanine nucleotide exchange factor 10
AliasesGEF10; SNCV
GeneCards (Weizmann)ARHGEF10
Ensembl hg19 (Hinxton)ENSG00000104728 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104728 [Gene_View]  chr8:1823976-1958641 [Contig_View]  ARHGEF10 [Vega]
ICGC DataPortalENSG00000104728
TCGA cBioPortalARHGEF10
AceView (NCBI)ARHGEF10
Genatlas (Paris)ARHGEF10
WikiGenes9639
SOURCE (Princeton)ARHGEF10
Genetics Home Reference (NIH)ARHGEF10
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGEF10  -     chr8:1823976-1958641 +  8p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGEF10  -     8p23.3   [Description]    (hg19-Feb_2009)
EnsemblARHGEF10 - 8p23.3 [CytoView hg19]  ARHGEF10 - 8p23.3 [CytoView hg38]
Mapping of homologs : NCBIARHGEF10 [Mapview hg19]  ARHGEF10 [Mapview hg38]
OMIM608136   608236   
Gene and transcription
Genbank (Entrez)AA758332 AB002292 AF009205 AI348138 AK309799
RefSeq transcript (Entrez)NM_001308152 NM_001308153 NM_014629
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_008480 NT_187576
Consensus coding sequences : CCDS (NCBI)ARHGEF10
Cluster EST : UnigeneHs.98594 [ NCBI ]
CGAP (NCI)Hs.98594
Alternative Splicing GalleryENSG00000104728
Gene ExpressionARHGEF10 [ NCBI-GEO ]   ARHGEF10 [ EBI - ARRAY_EXPRESS ]   ARHGEF10 [ SEEK ]   ARHGEF10 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9639
GTEX Portal (Tissue expression)ARHGEF10
Human Protein AtlasENSG00000104728-ARHGEF10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15013   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15013  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15013
Splice isoforms : SwissVarO15013
PhosPhoSitePlusO15013
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)   
Domains : Interpro (EBI)ARHGEF10    DH-domain    PH_dom-like    WD40/YVTN_repeat-like_dom    WD40_repeat_dom   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
pfam00621   
Domain families : Smart (EMBL)RhoGEF (SM00325)  
Conserved Domain (NCBI)ARHGEF10
DMDM Disease mutations9639
Blocks (Seattle)ARHGEF10
SuperfamilyO15013
Human Protein Atlas [tissue]ENSG00000104728-ARHGEF10 [tissue]
Peptide AtlasO15013
HPRD09735
IPIIPI00413517   IPI00419950   IPI00873672   IPI00979519   IPI00981196   IPI00419949   IPI00465414   
Protein Interaction databases
DIP (DOE-UCLA)O15013
IntAct (EBI)O15013
FunCoupENSG00000104728
BioGRIDARHGEF10
STRING (EMBL)ARHGEF10
ZODIACARHGEF10
Ontologies - Pathways
QuickGOO15013
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  protein binding  centrosome  cytosol  kinesin binding  myelination in peripheral nervous system  regulation of Rho protein signal transduction  centrosome duplication  positive regulation of stress fiber assembly  mitotic spindle assembly  activation of GTPase activity  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  protein binding  centrosome  cytosol  kinesin binding  myelination in peripheral nervous system  regulation of Rho protein signal transduction  centrosome duplication  positive regulation of stress fiber assembly  mitotic spindle assembly  activation of GTPase activity  
NDEx NetworkARHGEF10
Atlas of Cancer Signalling NetworkARHGEF10
Wikipedia pathwaysARHGEF10
Orthology - Evolution
OrthoDB9639
GeneTree (enSembl)ENSG00000104728
Phylogenetic Trees/Animal Genes : TreeFamARHGEF10
HOVERGENO15013
HOGENOMO15013
Homologs : HomoloGeneARHGEF10
Homology/Alignments : Family Browser (UCSC)ARHGEF10
Gene fusions - Rearrangements
Fusion: Tumor Portal ARHGEF10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF10
dbVarARHGEF10
ClinVarARHGEF10
1000_GenomesARHGEF10 
Exome Variant ServerARHGEF10
ExAC (Exome Aggregation Consortium)ENSG00000104728
GNOMAD BrowserENSG00000104728
Genetic variants : HAPMAP9639
Genomic Variants (DGV)ARHGEF10 [DGVbeta]
DECIPHERARHGEF10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGEF10 
Mutations
ICGC Data PortalARHGEF10 
TCGA Data PortalARHGEF10 
Broad Tumor PortalARHGEF10
OASIS PortalARHGEF10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF10
DgiDB (Drug Gene Interaction Database)ARHGEF10
DoCM (Curated mutations)ARHGEF10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF10 (select a term)
intoGenARHGEF10
Cancer3DARHGEF10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608136    608236   
Orphanet16976   
MedgenARHGEF10
Genetic Testing Registry ARHGEF10
NextProtO15013 [Medical]
TSGene9639
GENETestsARHGEF10
Target ValidationARHGEF10
Huge Navigator ARHGEF10 [HugePedia]
snp3D : Map Gene to Disease9639
BioCentury BCIQARHGEF10
ClinGenARHGEF10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9639
Chemical/Pharm GKB GenePA24967
Clinical trialARHGEF10
Miscellaneous
canSAR (ICR)ARHGEF10 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF10
EVEXARHGEF10
GoPubMedARHGEF10
iHOPARHGEF10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:40:50 CET 2017

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