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ARHGEF3 (Rho guanine nucleotide exchange factor 3)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 3
Alias_symbol (synonym)STA3
XPLN
GEF3
DKFZP434F2429
Other alias
HGNC (Hugo) ARHGEF3
LocusID (NCBI) 50650
Atlas_Id 43151
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 56761446 and ends at 57113336 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGEF3 (3p14.3) / ACP6 (1q21.2)ARHGEF3 (3p14.3) / ANO10 (3p22.1)ARHGEF3 (3p14.3) / FDFT1 (8p23.1)
ARHGEF3 (3p14.3) / HESX1 (3p14.3)ARHGEF3 (3p14.3) / ILVBL (19p13.12)ARHGEF3 (3p14.3) / MALAT1 (11q13.1)
ARHGEF3 (3p14.3) / NDUFAF6 (8q22.1)ARHGEF3 (3p14.3) / RHAG (6p12.3)ARHGEF3 (3p14.3) / RPL23 (17q12)
ARHGEF3 (3p14.3) / SDC4 (20q13.12)ERC2 (3p14.3) / ARHGEF3 (3p14.3)PVT1 (8q24.21) / ARHGEF3 (3p14.3)
ARHGEF3 3p14.3 / ACP6 1q21.2ARHGEF3 3p14.3 / ANO10 3p22.1ARHGEF3 3p14.3 / FDFT1 8p23.1
ARHGEF3 3p14.3 / HESX1 3p14.3ARHGEF3 3p14.3 / RHAG 6p12.3ERC2 3p14.3 / ARHGEF3 3p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGEF3   683
Cards
Entrez_Gene (NCBI)ARHGEF3  50650  Rho guanine nucleotide exchange factor 3
AliasesGEF3; STA3; XPLN
GeneCards (Weizmann)ARHGEF3
Ensembl hg19 (Hinxton)ENSG00000163947 [Gene_View]  chr3:56761446-57113336 [Contig_View]  ARHGEF3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163947 [Gene_View]  chr3:56761446-57113336 [Contig_View]  ARHGEF3 [Vega]
ICGC DataPortalENSG00000163947
TCGA cBioPortalARHGEF3
AceView (NCBI)ARHGEF3
Genatlas (Paris)ARHGEF3
WikiGenes50650
SOURCE (Princeton)ARHGEF3
Genetics Home Reference (NIH)ARHGEF3
Genomic and cartography
GoldenPath hg19 (UCSC)ARHGEF3  -     chr3:56761446-57113336 -  3p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARHGEF3  -     3p14.3   [Description]    (hg38-Dec_2013)
EnsemblARHGEF3 - 3p14.3 [CytoView hg19]  ARHGEF3 - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIARHGEF3 [Mapview hg19]  ARHGEF3 [Mapview hg38]
OMIM612115   
Gene and transcription
Genbank (Entrez)AB209661 AF249744 AF433662 AK024340 AK225688
RefSeq transcript (Entrez)NM_001128615 NM_001128616 NM_001289698 NM_019555
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)ARHGEF3
Cluster EST : UnigeneHs.476402 [ NCBI ]
CGAP (NCI)Hs.476402
Alternative Splicing GalleryENSG00000163947
Gene ExpressionARHGEF3 [ NCBI-GEO ]   ARHGEF3 [ EBI - ARRAY_EXPRESS ]   ARHGEF3 [ SEEK ]   ARHGEF3 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50650
GTEX Portal (Tissue expression)ARHGEF3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NR81   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NR81  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NR81
Splice isoforms : SwissVarQ9NR81
PhosPhoSitePlusQ9NR81
Domaine pattern : Prosite (Expaxy)DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DH-domain    GDS_CDC24_CS    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)ARHGEF3
DMDM Disease mutations50650
Blocks (Seattle)ARHGEF3
SuperfamilyQ9NR81
Human Protein AtlasENSG00000163947
Peptide AtlasQ9NR81
HPRD12480
IPIIPI00020949   IPI00385169   IPI00854602   IPI00946445   IPI00945383   IPI00791528   IPI00794649   IPI00792077   IPI00947543   IPI00981666   IPI00795793   IPI00944905   
Protein Interaction databases
DIP (DOE-UCLA)Q9NR81
IntAct (EBI)Q9NR81
FunCoupENSG00000163947
BioGRIDARHGEF3
STRING (EMBL)ARHGEF3
ZODIACARHGEF3
Ontologies - Pathways
QuickGOQ9NR81
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  cytosol  Rho protein signal transduction  regulation of Rho protein signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  cytosol  Rho protein signal transduction  regulation of Rho protein signal transduction  positive regulation of apoptotic process  positive regulation of GTPase activity  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGEF3
Atlas of Cancer Signalling NetworkARHGEF3
Wikipedia pathwaysARHGEF3
Orthology - Evolution
OrthoDB50650
GeneTree (enSembl)ENSG00000163947
Phylogenetic Trees/Animal Genes : TreeFamARHGEF3
HOVERGENQ9NR81
HOGENOMQ9NR81
Homologs : HomoloGeneARHGEF3
Homology/Alignments : Family Browser (UCSC)ARHGEF3
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF3/ACP6 [3p14.3/1q21.2]  
Fusion : MitelmanARHGEF3/ANO10 [3p14.3/3p22.1]  [t(3;3)(p14;p21)]  
Fusion : MitelmanARHGEF3/FDFT1 [3p14.3/8p23.1]  [t(3;8)(p14;p23)]  
Fusion : MitelmanARHGEF3/HESX1 [3p14.3/3p14.3]  [t(3;3)(p14;p14)]  
Fusion : MitelmanARHGEF3/NDUFAF6 [3p14.3/8q22.1]  [t(3;8)(p14;q22)]  
Fusion : MitelmanARHGEF3/RHAG [3p14.3/6p12.3]  [t(3;6)(p14;p12)]  
Fusion : MitelmanERC2/ARHGEF3 [3p14.3/3p14.3]  [t(3;3)(p14;p14)]  
Fusion : MitelmanPVT1/ARHGEF3 [8q24.21/3p14.3]  [t(3;8)(p14;q24)]  
Fusion: TCGAARHGEF3 3p14.3 ACP6 1q21.2 BRCA
Fusion: TCGAARHGEF3 3p14.3 ANO10 3p22.1 LUAD
Fusion: TCGAARHGEF3 3p14.3 FDFT1 8p23.1 PRAD
Fusion: TCGAARHGEF3 3p14.3 HESX1 3p14.3 BRCA
Fusion: TCGAARHGEF3 3p14.3 RHAG 6p12.3 LUAD
Fusion: TCGAERC2 3p14.3 ARHGEF3 3p14.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF3
dbVarARHGEF3
ClinVarARHGEF3
1000_GenomesARHGEF3 
Exome Variant ServerARHGEF3
ExAC (Exome Aggregation Consortium)ARHGEF3 (select the gene name)
Genetic variants : HAPMAP50650
Genomic Variants (DGV)ARHGEF3 [DGVbeta]
DECIPHER (Syndromes)3:56761446-57113336  ENSG00000163947
CONAN: Copy Number AnalysisARHGEF3 
Mutations
ICGC Data PortalARHGEF3 
TCGA Data PortalARHGEF3 
Broad Tumor PortalARHGEF3
OASIS PortalARHGEF3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF3
DgiDB (Drug Gene Interaction Database)ARHGEF3
DoCM (Curated mutations)ARHGEF3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF3 (select a term)
intoGenARHGEF3
Cancer3DARHGEF3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612115   
Orphanet
MedgenARHGEF3
Genetic Testing Registry ARHGEF3
NextProtQ9NR81 [Medical]
TSGene50650
GENETestsARHGEF3
Huge Navigator ARHGEF3 [HugePedia]
snp3D : Map Gene to Disease50650
BioCentury BCIQARHGEF3
ClinGenARHGEF3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50650
Chemical/Pharm GKB GenePA24973
Clinical trialARHGEF3
Miscellaneous
canSAR (ICR)ARHGEF3 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF3
EVEXARHGEF3
GoPubMedARHGEF3
iHOPARHGEF3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:52:58 CEST 2017

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