ARPC1B (actin related protein 2/3 complex subunit 1B)

2007-02-01  

Identity

HGNC
ARPC1B
LOCATION
7q22.1
LOCUSID
10095
ALIAS
ARC41,IMD71,PLTEID,p40-ARC,p41-ARC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10095
MIM: 604223
HGNC: 704
Ensembl: ENSG00000130429

Variants:

dbSNP: 10095
ClinVar: 10095
TCGA: ENSG00000130429
COSMIC: ARPC1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130429ENST00000414376C9JBJ7
ENSG00000130429ENST00000417330C9JEY1
ENSG00000130429ENST00000418347C9JTT6
ENSG00000130429ENST00000427217O15143
ENSG00000130429ENST00000427217A4D275
ENSG00000130429ENST00000429246C9JM51
ENSG00000130429ENST00000431816O15143
ENSG00000130429ENST00000431816A4D275
ENSG00000130429ENST00000432343F8VXW2
ENSG00000130429ENST00000443222C9K057
ENSG00000130429ENST00000445924F8WEB3
ENSG00000130429ENST00000451682O15143
ENSG00000130429ENST00000451682A4D275
ENSG00000130429ENST00000455009O15143
ENSG00000130429ENST00000455009A4D275
ENSG00000130429ENST00000458033O15143
ENSG00000130429ENST00000458033A4D275
ENSG00000130429ENST00000645391O15143
ENSG00000130429ENST00000645391A4D275
ENSG00000130429ENST00000646101O15143
ENSG00000130429ENST00000646101A4D275

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
147497192004p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.60
283680182017Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.33
206033262010Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.19
302541282018T-cell defects in patients with ARPC1B germline mutations account for combined immunodeficiency.13
291271442017Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.12
121155872002Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.11
261383912016Caveolin 1 (Cav-1) and actin-related protein 2/3 complex, subunit 1B (ARPC1B) expressions as prognostic indicators for oral squamous cell carcinoma (OSCC).4
167234372006Arpc1b gene is a candidate prediction marker for choroidal malignant melanomas sensitive to radiotherapy.3
274793552017Low-frequency nonsynonymous variants in FKBPL and ARPC1B genes are associated with breast cancer risk in Chinese women.1
317103102019Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.1

Citation

Dessen P

ARPC1B (actin related protein 2/3 complex subunit 1B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46311/arpc1b