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ATF6 (activating transcription factor 6)

Identity

Alias_symbol (synonym)ATF6A
Other aliasACHM7
HGNC (Hugo) ATF6
LocusID (NCBI) 22926
Atlas_Id 43841
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161736034 and ends at 161933860 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATF6 (1q23.3) / GJA5 (1q21.2)ATF6 (1q23.3) / PCP4L1 (1q23.3)ATF6 (1q23.3) / SH2D1B (1q23.3)
ATP6V0A1 (17q21.2) / ATF6 (1q23.3)CTBP1 (4p16.3) / ATF6 (1q23.3)MAGI3 (1p13.2) / ATF6 (1q23.3)
NMNAT2 (1q25.3) / ATF6 (1q23.3)NOS1AP (1q23.3) / ATF6 (1q23.3)PMEPA1 (20q13.31) / ATF6 (1q23.3)
ZNF318 (6p21.1) / ATF6 (1q23.3)ATF6 1q23.3 / GJA5 1q21.2ATF6 1q23.3 / PCP4L1 1q23.3
ATF6 1q23.3 / SH2D1B 1q23.3ATP6V0A1 17q21.2 / ATF6 1q23.3MAGI3 1p13.2 / ATF6 1q23.3
NMNAT2 1q25.3 / ATF6 1q23.3NOS1AP 1q23.3 / ATF6 1q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ATF6   791
Cards
Entrez_Gene (NCBI)ATF6  22926  activating transcription factor 6
AliasesACHM7; ATF6A
GeneCards (Weizmann)ATF6
Ensembl hg19 (Hinxton)ENSG00000118217 [Gene_View]  chr1:161736034-161933860 [Contig_View]  ATF6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118217 [Gene_View]  chr1:161736034-161933860 [Contig_View]  ATF6 [Vega]
ICGC DataPortalENSG00000118217
TCGA cBioPortalATF6
AceView (NCBI)ATF6
Genatlas (Paris)ATF6
WikiGenes22926
SOURCE (Princeton)ATF6
Genetics Home Reference (NIH)ATF6
Genomic and cartography
GoldenPath hg19 (UCSC)ATF6  -     chr1:161736034-161933860 +  1q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ATF6  -     1q23.3   [Description]    (hg38-Dec_2013)
EnsemblATF6 - 1q23.3 [CytoView hg19]  ATF6 - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIATF6 [Mapview hg19]  ATF6 [Mapview hg38]
OMIM605537   616517   
Gene and transcription
Genbank (Entrez)AB015856 AB208929 AF005887 AF088035 AK025316
RefSeq transcript (Entrez)NM_007348
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_029773 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)ATF6
Cluster EST : UnigeneHs.617868 [ NCBI ]
CGAP (NCI)Hs.617868
Alternative Splicing GalleryENSG00000118217
Gene ExpressionATF6 [ NCBI-GEO ]   ATF6 [ EBI - ARRAY_EXPRESS ]   ATF6 [ SEEK ]   ATF6 [ MEM ]
Gene Expression Viewer (FireBrowse)ATF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22926
GTEX Portal (Tissue expression)ATF6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18850   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18850  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18850
Splice isoforms : SwissVarP18850
PhosPhoSitePlusP18850
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)ATF6A    bZIP   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)   
Domain families : Pfam (NCBI)pfam00170   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)ATF6
DMDM Disease mutations22926
Blocks (Seattle)ATF6
SuperfamilyP18850
Human Protein AtlasENSG00000118217
Peptide AtlasP18850
HPRD16118
IPIIPI00002511   
Protein Interaction databases
DIP (DOE-UCLA)P18850
IntAct (EBI)P18850
FunCoupENSG00000118217
BioGRIDATF6
STRING (EMBL)ATF6
ZODIACATF6
Ontologies - Pathways
QuickGOP18850
Ontology : AmiGOGolgi membrane  transcription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  eye development  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleus  nuclear envelope  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein folding  response to stress  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  signal transduction  visual perception  membrane  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  endoplasmic reticulum unfolded protein response  ubiquitin protein ligase binding  cAMP response element binding  ATF6-mediated unfolded protein response  identical protein binding  protein heterodimerization activity  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIGolgi membrane  transcription regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  eye development  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleus  nuclear envelope  nucleoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein folding  response to stress  positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  signal transduction  visual perception  membrane  integral component of endoplasmic reticulum membrane  integral component of endoplasmic reticulum membrane  endoplasmic reticulum unfolded protein response  ubiquitin protein ligase binding  cAMP response element binding  ATF6-mediated unfolded protein response  identical protein binding  protein heterodimerization activity  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : KEGGProtein processing in endoplasmic reticulum    Alzheimer's disease   
NDEx NetworkATF6
Atlas of Cancer Signalling NetworkATF6
Wikipedia pathwaysATF6
Orthology - Evolution
OrthoDB22926
GeneTree (enSembl)ENSG00000118217
Phylogenetic Trees/Animal Genes : TreeFamATF6
HOVERGENP18850
HOGENOMP18850
Homologs : HomoloGeneATF6
Homology/Alignments : Family Browser (UCSC)ATF6
Gene fusions - Rearrangements
Fusion : MitelmanATF6/GJA5 [1q23.3/1q21.2]  
Fusion : MitelmanATF6/PCP4L1 [1q23.3/1q23.3]  [t(1;1)(q23;q23)]  
Fusion : MitelmanATF6/SH2D1B [1q23.3/1q23.3]  [t(1;1)(q23;q23)]  
Fusion : MitelmanATP6V0A1/ATF6 [17q21.2/1q23.3]  [t(1;17)(q23;q21)]  
Fusion : MitelmanMAGI3/ATF6 [1p13.2/1q23.3]  [t(1;1)(p13;q23)]  
Fusion : MitelmanNMNAT2/ATF6 [1q25.3/1q23.3]  [t(1;1)(q23;q25)]  
Fusion : MitelmanNOS1AP/ATF6 [1q23.3/1q23.3]  [t(1;1)(q23;q23)]  
Fusion: TCGAATF6 1q23.3 GJA5 1q21.2 LUAD
Fusion: TCGAATF6 1q23.3 PCP4L1 1q23.3 LUAD
Fusion: TCGAATF6 1q23.3 SH2D1B 1q23.3 BRCA
Fusion: TCGAATP6V0A1 17q21.2 ATF6 1q23.3 BRCA
Fusion: TCGAMAGI3 1p13.2 ATF6 1q23.3 BRCA
Fusion: TCGANMNAT2 1q25.3 ATF6 1q23.3 LGG
Fusion: TCGANOS1AP 1q23.3 ATF6 1q23.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATF6
dbVarATF6
ClinVarATF6
1000_GenomesATF6 
Exome Variant ServerATF6
ExAC (Exome Aggregation Consortium)ATF6 (select the gene name)
Genetic variants : HAPMAP22926
Genomic Variants (DGV)ATF6 [DGVbeta]
DECIPHER (Syndromes)1:161736034-161933860  ENSG00000118217
CONAN: Copy Number AnalysisATF6 
Mutations
ICGC Data PortalATF6 
TCGA Data PortalATF6 
Broad Tumor PortalATF6
OASIS PortalATF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDATF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ATF6
DgiDB (Drug Gene Interaction Database)ATF6
DoCM (Curated mutations)ATF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ATF6 (select a term)
intoGenATF6
Cancer3DATF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605537    616517   
Orphanet10639   
MedgenATF6
Genetic Testing Registry ATF6
NextProtP18850 [Medical]
TSGene22926
GENETestsATF6
Huge Navigator ATF6 [HugePedia]
snp3D : Map Gene to Disease22926
BioCentury BCIQATF6
ClinGenATF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22926
Chemical/Pharm GKB GenePA25091
Clinical trialATF6
Miscellaneous
canSAR (ICR)ATF6 (select the gene name)
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineATF6
EVEXATF6
GoPubMedATF6
iHOPATF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:56:48 CET 2017

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