Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ATG5 (autophagy related 5)

Identity

Alias (NCBI)APG5
APG5-LIKE
APG5L
ASP
SCAR25
hAPG5
HGNC (Hugo) ATG5
HGNC Alias symbASP
APG5
hAPG5
HGNC Previous nameAPG5L
HGNC Previous nameAPG5 (autophagy 5, S. cerevisiae)-like
 APG5 autophagy 5-like (S. cerevisiae)
 ATG5 autophagy related 5 homolog (S. cerevisiae)
LocusID (NCBI) 9474
Atlas_Id 51040
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 106184477 and ends at 106325760 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATG5 (6q21) / ATG5 (6q21)ATG5 (6q21) / CEACAM16 (19q13.32)ATG5 (6q21) / EIF3E (8q23.1)
ATG5 (6q21) / PDSS2 (6q21)ATG5 (6q21) / QRSL1 (6q21)ATG5 (6q21) / SYNJ2 (6q25.3)
ATG5 (6q21) / TMEM200A (6q23.1)ATG5 (6q21) / UBE2G2 (21q22.3)CCT4 (2p15) / ATG5 (6q21)
GOLGB1 (3q13.33) / ATG5 (6q21)LTV1 (6q24.2) / ATG5 (6q21)PREP (6q21) / ATG5 (6q21)
ATG5 6q21 / CEACAM16 19q13.32ATG5 6q21 / PDSS2 6q21ATG5 6q21 / QRSL1 6q21
ATG5 6q21 / SYNJ2 6q25.3ATG5 6q21 / TMEM200A 6q23.1LTV1 6q24.2 / ATG5 6q21
PREP 6q21 / ATG5 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Aggressive natural killer leukemia (ANKL)


External links

 

Nomenclature
HGNC (Hugo)ATG5   589
Cards
Entrez_Gene (NCBI)ATG5    autophagy related 5
AliasesAPG5; APG5-LIKE; APG5L; ASP; 
SCAR25; hAPG5
GeneCards (Weizmann)ATG5
Ensembl hg19 (Hinxton)ENSG00000057663 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000057663 [Gene_View]  ENSG00000057663 [Sequence]  chr6:106184477-106325760 [Contig_View]  ATG5 [Vega]
ICGC DataPortalENSG00000057663
TCGA cBioPortalATG5
AceView (NCBI)ATG5
Genatlas (Paris)ATG5
SOURCE (Princeton)ATG5
Genetics Home Reference (NIH)ATG5
Genomic and cartography
GoldenPath hg38 (UCSC)ATG5  -     chr6:106184477-106325760 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ATG5  -     6q21   [Description]    (hg19-Feb_2009)
GoldenPathATG5 - 6q21 [CytoView hg19]  ATG5 - 6q21 [CytoView hg38]
ImmunoBaseENSG00000057663
Genome Data Viewer NCBIATG5 [Mapview hg19]  
OMIM604261   617584   
Gene and transcription
Genbank (Entrez)AF293841 AK001899 AK299577 AK315800 BC002699
RefSeq transcript (Entrez)NM_001286106 NM_001286107 NM_001286108 NM_001286111 NM_004849
Consensus coding sequences : CCDS (NCBI)ATG5
Gene ExpressionATG5 [ NCBI-GEO ]   ATG5 [ EBI - ARRAY_EXPRESS ]   ATG5 [ SEEK ]   ATG5 [ MEM ]
Gene Expression Viewer (FireBrowse)ATG5 [ Firebrowse - Broad ]
GenevisibleExpression of ATG5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9474
GTEX Portal (Tissue expression)ATG5
Human Protein AtlasENSG00000057663-ATG5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H1Y0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H1Y0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H1Y0
PhosPhoSitePlusQ9H1Y0
Domains : Interpro (EBI)Atg5    Atg5_HR    Atg5_UblA_dom   
Domain families : Pfam (Sanger)APG5 (PF04106)   
Domain families : Pfam (NCBI)pfam04106   
Conserved Domain (NCBI)ATG5
PDB (RSDB)4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
PDB Europe4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
PDB (PDBSum)4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
PDB (IMB)4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
Structural Biology KnowledgeBase4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
SCOP (Structural Classification of Proteins)4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
CATH (Classification of proteins structures)4GDK    4GDL    4NAW    4TQ0    4TQ1    5D7G    5NPV    5NPW   
SuperfamilyQ9H1Y0
AlphaFold pdb e-kbQ9H1Y0   
Human Protein Atlas [tissue]ENSG00000057663-ATG5 [tissue]
HPRD16051
Protein Interaction databases
DIP (DOE-UCLA)Q9H1Y0
IntAct (EBI)Q9H1Y0
BioGRIDATG5
STRING (EMBL)ATG5
ZODIACATG5
Ontologies - Pathways
QuickGOQ9H1Y0
Ontology : AmiGOautophagosome assembly  autophagosome assembly  autophagy of mitochondrion  blood vessel remodeling  regulation of cytokine production involved in immune response  protein binding  cytoplasm  autophagosome  cytosol  axoneme  C-terminal protein lipidation  autophagy  autophagy  apoptotic process  cellular response to nitrogen starvation  response to fungus  membrane  macroautophagy  antigen processing and presentation of endogenous antigen  phagocytic vesicle membrane  negative regulation of protein ubiquitination  phagophore assembly site membrane  phagophore assembly site membrane  Atg12-Atg5-Atg16 complex  aggrephagy  negative stranded viral RNA replication  vasodilation  response to drug  negative regulation of apoptotic process  post-translational protein modification  mitochondria-associated endoplasmic reticulum membrane  autophagy of nucleus  negative thymic T cell selection  otolith development  negative regulation of phagocytosis  regulation of release of sequestered calcium ion into cytosol  ventricular cardiac muscle cell development  heart contraction  negative regulation of cell death  protein lipidation involved in autophagosome assembly  positive regulation of mucus secretion  cellular response to nitrosative stress  positive regulation by symbiont of host autophagy  regulation of cilium assembly  negative regulation of reactive oxygen species metabolic process  negative regulation of histone H4-K16 acetylation  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  autophagy of mitochondrion  blood vessel remodeling  regulation of cytokine production involved in immune response  protein binding  cytoplasm  autophagosome  cytosol  axoneme  C-terminal protein lipidation  autophagy  autophagy  apoptotic process  cellular response to nitrogen starvation  response to fungus  membrane  macroautophagy  antigen processing and presentation of endogenous antigen  phagocytic vesicle membrane  negative regulation of protein ubiquitination  phagophore assembly site membrane  phagophore assembly site membrane  Atg12-Atg5-Atg16 complex  aggrephagy  negative stranded viral RNA replication  vasodilation  response to drug  negative regulation of apoptotic process  post-translational protein modification  mitochondria-associated endoplasmic reticulum membrane  autophagy of nucleus  negative thymic T cell selection  otolith development  negative regulation of phagocytosis  regulation of release of sequestered calcium ion into cytosol  ventricular cardiac muscle cell development  heart contraction  negative regulation of cell death  protein lipidation involved in autophagosome assembly  positive regulation of mucus secretion  cellular response to nitrosative stress  positive regulation by symbiont of host autophagy  regulation of cilium assembly  negative regulation of reactive oxygen species metabolic process  negative regulation of histone H4-K16 acetylation  
Pathways : KEGGRegulation of autophagy    RIG-I-like receptor signaling pathway    Shigellosis   
NDEx NetworkATG5
Atlas of Cancer Signalling NetworkATG5
Wikipedia pathwaysATG5
Orthology - Evolution
OrthoDB9474
GeneTree (enSembl)ENSG00000057663
Phylogenetic Trees/Animal Genes : TreeFamATG5
Homologs : HomoloGeneATG5
Homology/Alignments : Family Browser (UCSC)ATG5
Gene fusions - Rearrangements
Fusion : MitelmanATG5/CEACAM16 [6q21/19q13.32]  
Fusion : MitelmanATG5/SYNJ2 [6q21/6q25.3]  
Fusion : MitelmanATG5/TMEM200A [6q21/6q23.1]  
Fusion : MitelmanLTV1/ATG5 [6q24.2/6q21]  
Fusion : QuiverATG5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerATG5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ATG5
dbVarATG5
ClinVarATG5
MonarchATG5
1000_GenomesATG5 
Exome Variant ServerATG5
GNOMAD BrowserENSG00000057663
Varsome BrowserATG5
ACMGATG5 variants
VarityQ9H1Y0
Genomic Variants (DGV)ATG5 [DGVbeta]
DECIPHERATG5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisATG5 
Mutations
ICGC Data PortalATG5 
TCGA Data PortalATG5 
Broad Tumor PortalATG5
OASIS PortalATG5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICATG5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DATG5
Mutations and Diseases : HGMDATG5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaATG5
DgiDB (Drug Gene Interaction Database)ATG5
DoCM (Curated mutations)ATG5
CIViC (Clinical Interpretations of Variants in Cancer)ATG5
Cancer3DATG5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604261    617584   
Orphanet
DisGeNETATG5
MedgenATG5
Genetic Testing Registry ATG5
NextProtQ9H1Y0 [Medical]
GENETestsATG5
Target ValidationATG5
Huge Navigator ATG5 [HugePedia]
ClinGenATG5
Clinical trials, drugs, therapy
MyCancerGenomeATG5
Protein Interactions : CTDATG5
Pharm GKB GenePA24880
PharosQ9H1Y0
Clinical trialATG5
Miscellaneous
canSAR (ICR)ATG5
HarmonizomeATG5
DataMed IndexATG5
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXATG5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:00:27 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.