ATG5 (autophagy related 5)

2009-08-01 Affiliation

Identity

HGNC

ATG5

LOCATION

6q21

LOCUSID

9474

ALIAS

APG5,APG5-LIKE,APG5L,ASP,SCAR25,hAPG5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9474
MIM: 604261
HGNC: 589
Ensembl: ENSG00000057663

Variants:

dbSNP: 9474
ClinVar: 9474
TCGA: ENSG00000057663
COSMIC: ATG5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000057663	ENST00000343245	Q9H1Y0
ENSG00000057663	ENST00000343245	A9UGY9
ENSG00000057663	ENST00000360666	Q7Z3H3
ENSG00000057663	ENST00000369070	L7UMD8
ENSG00000057663	ENST00000369076	Q9H1Y0
ENSG00000057663	ENST00000369076	A9UGY9
ENSG00000057663	ENST00000613993	L7UQJ2
ENSG00000057663	ENST00000635758	Q9H1Y0
ENSG00000057663	ENST00000636335	A0A1B0GUS1
ENSG00000057663	ENST00000636437	A0A1B0GV54
ENSG00000057663	ENST00000646025	A0A2R8Y718

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
Autophagy - animal	KEGG	hsa04140
Shigellosis	KEGG	hsa05131
RIG-I-like receptor signaling pathway	KEGG	ko04622
RIG-I-like receptor signaling pathway	KEGG	hsa04622
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	REACTOME	R-HSA-168928
Negative regulators of RIG-I/MDA5 signaling	REACTOME	R-HSA-936440
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Mitophagy	REACTOME	R-HSA-5205647
Pink/Parkin Mediated Mitophagy	REACTOME	R-HSA-5205685
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Mitophagy - animal	KEGG	ko04137
Mitophagy - animal	KEGG	hsa04137
Autophagy - other	KEGG	ko04136
Ferroptosis	KEGG	ko04216
Autophagy - other	KEGG	hsa04136
Ferroptosis	KEGG	hsa04216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10004	adalimumab	Chemical	ClinicalAnnotation	associated		PD	27096233
PA446116	Inflammatory Bowel Diseases	Disease	ClinicalAnnotation	associated		PD	27096233

References

Pubmed ID	Year	Title	Citations
20038797	2010	The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.	254
15778222	2005	Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death.	210
18353420	2008	Autophagic machinery activated by dengue virus enhances virus replication.	150
19148225	2009	PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.	135
19881538	2010	Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.	127
27245739	2016	Autophagy promotes ferroptosis by degradation of ferritin.	120
23202584	2013	Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.	109
19124466	2009	Regulation of autophagy by the p300 acetyltransferase.	86
21655094	2011	EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells.	85
21622776	2011	Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population.	84

Citation

Dessen P

ATG5 (autophagy related 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51040/atg5