BDKRB1 (bradykinin receptor B1)

2007-02-01 Affiliation

Identity

HGNC

BDKRB1

LOCATION

14q32.2

LOCUSID

623

ALIAS

B1BKR,B1R,BKB1R,BKR1,BRADYB1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 623
MIM: 600337
HGNC: 1029
Ensembl: ENSG00000100739

Variants:

dbSNP: 623
ClinVar: 623
TCGA: ENSG00000100739
COSMIC: BDKRB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100739	ENST00000216629	P46663
ENSG00000100739	ENST00000553356	G3V4Y2
ENSG00000100739	ENST00000611804	P46663

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Complement and coagulation cascades	KEGG	ko04610
Regulation of actin cytoskeleton	KEGG	ko04810
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Complement and coagulation cascades	KEGG	hsa04610
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated		PD	20712529
PA450877	perindopril	Chemical	ClinicalAnnotation	associated		PD	20712529

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15520046	2004	Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes.	45
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
28935640	2018	Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg⁹ bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.	27
21216565	2011	Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.	26
17110500	2007	Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis.	24
17328065	2007	Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.	23
18809736	2009	Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy.	23
19796797	2009	Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency.	20
11880373	2002	Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.	18

Citation

Dessen P

BDKRB1 (bradykinin receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46143/bdkrb1