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BRSK2 (BR serine/threonine kinase 2)

Identity

Alias_namesC11orf7
STK29
chromsosome 11 open reading frame 7
Alias_symbol (synonym)PEN11B
Other aliasSAD1
SADA
HGNC (Hugo) BRSK2
LocusID (NCBI) 9024
Atlas_Id 43174
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1411129 and ends at 1483919 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LRCH3 (3q29) / BRSK2 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)BRSK2   11405
Cards
Entrez_Gene (NCBI)BRSK2  9024  BR serine/threonine kinase 2
AliasesC11orf7; PEN11B; SAD1; SADA; 
STK29
GeneCards (Weizmann)BRSK2
Ensembl hg19 (Hinxton)ENSG00000174672 [Gene_View]  chr11:1411129-1483919 [Contig_View]  BRSK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174672 [Gene_View]  chr11:1411129-1483919 [Contig_View]  BRSK2 [Vega]
ICGC DataPortalENSG00000174672
TCGA cBioPortalBRSK2
AceView (NCBI)BRSK2
Genatlas (Paris)BRSK2
WikiGenes9024
SOURCE (Princeton)BRSK2
Genetics Home Reference (NIH)BRSK2
Genomic and cartography
GoldenPath hg19 (UCSC)BRSK2  -     chr11:1411129-1483919 +  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)BRSK2  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblBRSK2 - 11p15.5 [CytoView hg19]  BRSK2 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBIBRSK2 [Mapview hg19]  BRSK2 [Mapview hg38]
OMIM609236   
Gene and transcription
Genbank (Entrez)AF020089 AF533876 AF533877 AF533878 AF533879
RefSeq transcript (Entrez)NM_001256627 NM_001256629 NM_001256630 NM_001282218 NM_003957
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)BRSK2
Cluster EST : UnigeneHs.170819 [ NCBI ]
CGAP (NCI)Hs.170819
Alternative Splicing GalleryENSG00000174672
Gene ExpressionBRSK2 [ NCBI-GEO ]   BRSK2 [ EBI - ARRAY_EXPRESS ]   BRSK2 [ SEEK ]   BRSK2 [ MEM ]
Gene Expression Viewer (FireBrowse)BRSK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9024
GTEX Portal (Tissue expression)BRSK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWQ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWQ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWQ3
Splice isoforms : SwissVarQ8IWQ3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IWQ3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)BRSK2
DMDM Disease mutations9024
Blocks (Seattle)BRSK2
SuperfamilyQ8IWQ3
Human Protein AtlasENSG00000174672
Peptide AtlasQ8IWQ3
IPIIPI00744296   IPI00339266   IPI00028344   IPI00604667   IPI00339265   IPI01011203   IPI00446679   IPI00982611   IPI00980315   IPI01015628   IPI00979722   IPI00983170   
Protein Interaction databases
DIP (DOE-UCLA)Q8IWQ3
IntAct (EBI)Q8IWQ3
FunCoupENSG00000174672
BioGRIDBRSK2
STRING (EMBL)BRSK2
ZODIACBRSK2
Ontologies - Pathways
QuickGOQ8IWQ3
Ontology : AmiGOG2/M transition of mitotic cell cycle  magnesium ion binding  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  endoplasmic reticulum  centrosome  protein phosphorylation  exocytosis  mitotic nuclear division  axonogenesis  peptidyl-serine phosphorylation  protein kinase binding  establishment of cell polarity  neuron differentiation  actin cytoskeleton reorganization  ERAD pathway  regulation of ATPase activity  perinuclear region of cytoplasm  tau-protein kinase activity  tau-protein kinase activity  ATPase binding  cell division  ATPase regulator activity  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of insulin secretion involved in cellular response to glucose stimulus  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  regulation of retrograde protein transport, ER to cytosol  regulation of retrograde protein transport, ER to cytosol  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  magnesium ion binding  protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  endoplasmic reticulum  centrosome  protein phosphorylation  exocytosis  mitotic nuclear division  axonogenesis  peptidyl-serine phosphorylation  protein kinase binding  establishment of cell polarity  neuron differentiation  actin cytoskeleton reorganization  ERAD pathway  regulation of ATPase activity  perinuclear region of cytoplasm  tau-protein kinase activity  tau-protein kinase activity  ATPase binding  cell division  ATPase regulator activity  regulation of insulin secretion involved in cellular response to glucose stimulus  regulation of insulin secretion involved in cellular response to glucose stimulus  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  regulation of retrograde protein transport, ER to cytosol  regulation of retrograde protein transport, ER to cytosol  
NDEx NetworkBRSK2
Atlas of Cancer Signalling NetworkBRSK2
Wikipedia pathwaysBRSK2
Orthology - Evolution
OrthoDB9024
GeneTree (enSembl)ENSG00000174672
Phylogenetic Trees/Animal Genes : TreeFamBRSK2
HOVERGENQ8IWQ3
HOGENOMQ8IWQ3
Homologs : HomoloGeneBRSK2
Homology/Alignments : Family Browser (UCSC)BRSK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerBRSK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)BRSK2
dbVarBRSK2
ClinVarBRSK2
1000_GenomesBRSK2 
Exome Variant ServerBRSK2
ExAC (Exome Aggregation Consortium)BRSK2 (select the gene name)
Genetic variants : HAPMAP9024
Genomic Variants (DGV)BRSK2 [DGVbeta]
DECIPHER (Syndromes)11:1411129-1483919  ENSG00000174672
CONAN: Copy Number AnalysisBRSK2 
Mutations
ICGC Data PortalBRSK2 
TCGA Data PortalBRSK2 
Broad Tumor PortalBRSK2
OASIS PortalBRSK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICBRSK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDBRSK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch BRSK2
DgiDB (Drug Gene Interaction Database)BRSK2
DoCM (Curated mutations)BRSK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)BRSK2 (select a term)
intoGenBRSK2
Cancer3DBRSK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609236   
Orphanet
MedgenBRSK2
Genetic Testing Registry BRSK2
NextProtQ8IWQ3 [Medical]
TSGene9024
GENETestsBRSK2
Huge Navigator BRSK2 [HugePedia]
snp3D : Map Gene to Disease9024
BioCentury BCIQBRSK2
ClinGenBRSK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9024
Chemical/Pharm GKB GenePA36212
Clinical trialBRSK2
Miscellaneous
canSAR (ICR)BRSK2 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineBRSK2
EVEXBRSK2
GoPubMedBRSK2
iHOPBRSK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:57:52 CET 2017

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