Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

C4BPA (complement component 4 binding protein alpha)

Identity

Alias_namesC4BP
complement component 4-binding protein
Other aliasPRP
HGNC (Hugo) C4BPA
LocusID (NCBI) 722
Atlas_Id 49852
Location 1q32.2  [Link to chromosome band 1q32]
Location_base_pair Starts at 207104262 and ends at 207144972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		C4BPA (1q32.2) / C4BPB (1q32.2)CCDC109B (4q25) / C4BPA (1q32.2)CD55 (1q32.2) / C4BPA (1q32.2)
CCDC109B 4q25 / C4BPA 1q32.2CD55 1q32.2 / C4BPA 1q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)C4BPA   1325
Cards
Entrez_Gene (NCBI)C4BPA  722  complement component 4 binding protein alpha
AliasesC4BP; PRP
GeneCards (Weizmann)C4BPA
Ensembl hg19 (Hinxton)ENSG00000123838 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123838 [Gene_View]  chr1:207104262-207144972 [Contig_View]  C4BPA [Vega]
ICGC DataPortalENSG00000123838
TCGA cBioPortalC4BPA
AceView (NCBI)C4BPA
Genatlas (Paris)C4BPA
WikiGenes722
SOURCE (Princeton)C4BPA
Genetics Home Reference (NIH)C4BPA
Genomic and cartography
GoldenPath hg38 (UCSC)C4BPA  -     chr1:207104262-207144972 +  1q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)C4BPA  -     1q32.2   [Description]    (hg19-Feb_2009)
EnsemblC4BPA - 1q32.2 [CytoView hg19]  C4BPA - 1q32.2 [CytoView hg38]
Mapping of homologs : NCBIC4BPA [Mapview hg19]  C4BPA [Mapview hg38]
OMIM120830   
Gene and transcription
Genbank (Entrez)AK303793 AK303798 AK313164 BC022312 BQ019292
RefSeq transcript (Entrez)NM_000715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)C4BPA
Cluster EST : UnigeneHs.1012 [ NCBI ]
CGAP (NCI)Hs.1012
Alternative Splicing GalleryENSG00000123838
Gene ExpressionC4BPA [ NCBI-GEO ]   C4BPA [ EBI - ARRAY_EXPRESS ]   C4BPA [ SEEK ]   C4BPA [ MEM ]
Gene Expression Viewer (FireBrowse)C4BPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)722
GTEX Portal (Tissue expression)C4BPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04003   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04003  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04003
Splice isoforms : SwissVarP04003
PhosPhoSitePlusP04003
Domaine pattern : Prosite (Expaxy)SUSHI (PS50923)   
Domains : Interpro (EBI)Sushi_SCR_CCP_dom   
Domain families : Pfam (Sanger)Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  
Conserved Domain (NCBI)C4BPA
DMDM Disease mutations722
Blocks (Seattle)C4BPA
PDB (SRS)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
PDB (PDBSum)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
PDB (IMB)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
PDB (RSDB)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
Structural Biology KnowledgeBase2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
SCOP (Structural Classification of Proteins)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
CATH (Classification of proteins structures)2A55    4B0F    5HYP    5HYT    5HYU    5HZP    5I0Q   
SuperfamilyP04003
Human Protein AtlasENSG00000123838
Peptide AtlasP04003
HPRD00403
IPIIPI00021727   IPI00872510   IPI00855766   IPI00880200   
Protein Interaction databases
DIP (DOE-UCLA)P04003
IntAct (EBI)P04003
FunCoupENSG00000123838
BioGRIDC4BPA
STRING (EMBL)C4BPA
ZODIACC4BPA
Ontologies - Pathways
QuickGOP04003
Ontology : AmiGORNA binding  protein binding  extracellular region  extracellular space  plasma membrane  complement activation, classical pathway  regulation of complement activation  other organism cell  innate immune response  positive regulation of protein catabolic process  negative regulation of complement activation, classical pathway  blood microparticle  regulation of opsonization  
Ontology : EGO-EBIRNA binding  protein binding  extracellular region  extracellular space  plasma membrane  complement activation, classical pathway  regulation of complement activation  other organism cell  innate immune response  positive regulation of protein catabolic process  negative regulation of complement activation, classical pathway  blood microparticle  regulation of opsonization  
Pathways : KEGGComplement and coagulation cascades    Pertussis   
NDEx NetworkC4BPA
Atlas of Cancer Signalling NetworkC4BPA
Wikipedia pathwaysC4BPA
Orthology - Evolution
OrthoDB722
GeneTree (enSembl)ENSG00000123838
Phylogenetic Trees/Animal Genes : TreeFamC4BPA
HOVERGENP04003
HOGENOMP04003
Homologs : HomoloGeneC4BPA
Homology/Alignments : Family Browser (UCSC)C4BPA
Gene fusions - Rearrangements
Fusion : MitelmanCCDC109B/C4BPA [4q25/1q32.2]  [t(1;4)(q32;q25)]  
Fusion : MitelmanCD55/C4BPA [1q32.2/1q32.2]  [t(1;1)(q32;q32)]  
Fusion: TCGACCDC109B 4q25 C4BPA 1q32.2 BRCA
Fusion: TCGACD55 1q32.2 C4BPA 1q32.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerC4BPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)C4BPA
dbVarC4BPA
ClinVarC4BPA
1000_GenomesC4BPA 
Exome Variant ServerC4BPA
ExAC (Exome Aggregation Consortium)C4BPA (select the gene name)
Genetic variants : HAPMAP722
Genomic Variants (DGV)C4BPA [DGVbeta]
DECIPHERC4BPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisC4BPA 
Mutations
ICGC Data PortalC4BPA 
TCGA Data PortalC4BPA 
Broad Tumor PortalC4BPA
OASIS PortalC4BPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICC4BPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDC4BPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch C4BPA
DgiDB (Drug Gene Interaction Database)C4BPA
DoCM (Curated mutations)C4BPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)C4BPA (select a term)
intoGenC4BPA
Cancer3DC4BPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120830   
Orphanet
MedgenC4BPA
Genetic Testing Registry C4BPA
NextProtP04003 [Medical]
TSGene722
GENETestsC4BPA
Target ValidationC4BPA
Huge Navigator C4BPA [HugePedia]
snp3D : Map Gene to Disease722
BioCentury BCIQC4BPA
ClinGenC4BPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD722
Chemical/Pharm GKB GenePA25905
Clinical trialC4BPA
Miscellaneous
canSAR (ICR)C4BPA (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineC4BPA
EVEXC4BPA
GoPubMedC4BPA
iHOPC4BPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:48:26 CEST 2017
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.