CA9 (carbonic anhydrase 9)

2003-06-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
CAIX,MN

Other Information

Locus ID:

NCBI: 768
MIM: 603179
HGNC: 1383
Ensembl: ENSG00000107159

Variants:

dbSNP: 768
ClinVar: 768
TCGA: ENSG00000107159
COSMIC: CA9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107159ENST00000378357Q16790
ENSG00000107159ENST00000378357A0A0S2Z3D0
ENSG00000107159ENST00000617161A0A087WYS4

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Nitrogen metabolismKEGGko00910
Nitrogen metabolismKEGGhsa00910
MetabolismREACTOMER-HSA-1430728
Reversible hydration of carbon dioxideREACTOMER-HSA-1475029
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448871celecoxibChemicalPathwayassociated22336956

References

Pubmed IDYearTitleCitations
180600362007IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.290
155566242004Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.129
125764532003Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy.117
222897412012Recent developments in targeting carbonic anhydrase IX for cancer therapeutics.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
165337752006An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.84
194580842009The role of carbonic anhydrase 9 in regulating extracellular and intracellular ph in three-dimensional tumor cell growths.81
172456992007HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome.77
191652032009The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy.75
232085052013Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.73

Citation

Dessen P

CA9 (carbonic anhydrase 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/898/ca9