CALCRL (calcitonin receptor like receptor)

2009-06-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
CGRPR,CRLR,LMPHM8
FUSION GENES

Other Information

Locus ID:

NCBI: 10203
MIM: 114190
HGNC: 16709
Ensembl: ENSG00000064989

Variants:

dbSNP: 10203
ClinVar: 10203
TCGA: ENSG00000064989
COSMIC: CALCRL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064989ENST00000392370Q16602
ENSG00000064989ENST00000409998Q16602
ENSG00000064989ENST00000410068Q16602
ENSG00000064989ENST00000410102B8ZZJ4
ENSG00000064989ENST00000447403E7EN01

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
259821132015Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.35
176752982007Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor.34
302094002018Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.34
119734352002Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature.33
177854632007Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1.31
156134682005Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.29
173100672007Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1.29
221023692012Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.24

Citation

Dessen P

CALCRL (calcitonin receptor like receptor)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50973/calcrl