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CALCRL (calcitonin receptor like receptor)

Identity

Alias_namescalcitonin receptor-like
Alias_symbol (synonym)CGRPR
CRLR
Other alias
HGNC (Hugo) CALCRL
LocusID (NCBI) 10203
Atlas_Id 50973
Location 2q32.1  [Link to chromosome band 2q32]
Location_base_pair Starts at 187341963 and ends at 187448294 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MFSD6 (2q32.2) / CALCRL (2q32.1)MFSD6 2q32.2 / CALCRL 2q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CALCRL   16709
Cards
Entrez_Gene (NCBI)CALCRL  10203  calcitonin receptor like receptor
AliasesCGRPR; CRLR
GeneCards (Weizmann)CALCRL
Ensembl hg19 (Hinxton)ENSG00000064989 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000064989 [Gene_View]  chr2:187341963-187448294 [Contig_View]  CALCRL [Vega]
ICGC DataPortalENSG00000064989
TCGA cBioPortalCALCRL
AceView (NCBI)CALCRL
Genatlas (Paris)CALCRL
WikiGenes10203
SOURCE (Princeton)CALCRL
Genetics Home Reference (NIH)CALCRL
Genomic and cartography
GoldenPath hg38 (UCSC)CALCRL  -     chr2:187341963-187448294 -  2q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CALCRL  -     2q32.1   [Description]    (hg19-Feb_2009)
EnsemblCALCRL - 2q32.1 [CytoView hg19]  CALCRL - 2q32.1 [CytoView hg38]
Mapping of homologs : NCBICALCRL [Mapview hg19]  CALCRL [Mapview hg38]
OMIM114190   
Gene and transcription
Genbank (Entrez)AA436933 AA961493 AK291630 AK292998 AL602685
RefSeq transcript (Entrez)NM_001271751 NM_005795
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CALCRL
Cluster EST : UnigeneHs.744587 [ NCBI ]
CGAP (NCI)Hs.744587
Alternative Splicing GalleryENSG00000064989
Gene ExpressionCALCRL [ NCBI-GEO ]   CALCRL [ EBI - ARRAY_EXPRESS ]   CALCRL [ SEEK ]   CALCRL [ MEM ]
Gene Expression Viewer (FireBrowse)CALCRL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10203
GTEX Portal (Tissue expression)CALCRL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16602
Splice isoforms : SwissVarQ16602
PhosPhoSitePlusQ16602
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F2_1 (PS00649)    G_PROTEIN_RECEP_F2_2 (PS00650)    G_PROTEIN_RECEP_F2_3 (PS50227)    G_PROTEIN_RECEP_F2_4 (PS50261)   
Domains : Interpro (EBI)GCPR_2_calcitonin_rcpt_fam    GPCR_2-like    GPCR_2_CGRP1_rcpt    GPCR_2_extracellular_dom    GPCR_2_secretin-like    GPCR_2_secretin-like_CS   
Domain families : Pfam (Sanger)7tm_2 (PF00002)    HRM (PF02793)   
Domain families : Pfam (NCBI)pfam00002    pfam02793   
Domain families : Smart (EMBL)HormR (SM00008)  
Conserved Domain (NCBI)CALCRL
DMDM Disease mutations10203
Blocks (Seattle)CALCRL
PDB (SRS)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
PDB (PDBSum)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
PDB (IMB)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
PDB (RSDB)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
Structural Biology KnowledgeBase3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
SCOP (Structural Classification of Proteins)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
CATH (Classification of proteins structures)3AQF    3N7P    3N7R    3N7S    4RWF    4RWG   
SuperfamilyQ16602
Human Protein AtlasENSG00000064989
Peptide AtlasQ16602
HPRD11809
IPIIPI00916380   IPI00873582   IPI00719593   IPI00917347   IPI00916523   
Protein Interaction databases
DIP (DOE-UCLA)Q16602
IntAct (EBI)Q16602
FunCoupENSG00000064989
BioGRIDCALCRL
STRING (EMBL)CALCRL
ZODIACCALCRL
Ontologies - Pathways
QuickGOQ16602
Ontology : AmiGOangiogenesis  adrenomedullin receptor activity  calcitonin gene-related peptide receptor activity  G-protein coupled receptor activity  calcitonin receptor activity  protein binding  lysosome  endosome  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  calcium ion transport  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating G-protein coupled receptor signaling pathway  heart development  protein transporter activity  protein transport  positive regulation of cAMP biosynthetic process  positive regulation of cAMP biosynthetic process  receptor internalization  negative regulation of smooth muscle contraction  positive regulation of smooth muscle cell proliferation  negative regulation of inflammatory response  cellular response to sucrose stimulus  
Ontology : EGO-EBIangiogenesis  adrenomedullin receptor activity  calcitonin gene-related peptide receptor activity  G-protein coupled receptor activity  calcitonin receptor activity  protein binding  lysosome  endosome  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  cAMP biosynthetic process  calcium ion transport  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  adenylate cyclase-activating G-protein coupled receptor signaling pathway  heart development  protein transporter activity  protein transport  positive regulation of cAMP biosynthetic process  positive regulation of cAMP biosynthetic process  receptor internalization  negative regulation of smooth muscle contraction  positive regulation of smooth muscle cell proliferation  negative regulation of inflammatory response  cellular response to sucrose stimulus  
Pathways : KEGGNeuroactive ligand-receptor interaction    Vascular smooth muscle contraction   
NDEx NetworkCALCRL
Atlas of Cancer Signalling NetworkCALCRL
Wikipedia pathwaysCALCRL
Orthology - Evolution
OrthoDB10203
GeneTree (enSembl)ENSG00000064989
Phylogenetic Trees/Animal Genes : TreeFamCALCRL
HOVERGENQ16602
HOGENOMQ16602
Homologs : HomoloGeneCALCRL
Homology/Alignments : Family Browser (UCSC)CALCRL
Gene fusions - Rearrangements
Fusion : MitelmanMFSD6/CALCRL [2q32.2/2q32.1]  [t(2;2)(q32;q32)]  
Fusion: TCGAMFSD6 2q32.2 CALCRL 2q32.1 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCALCRL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CALCRL
dbVarCALCRL
ClinVarCALCRL
1000_GenomesCALCRL 
Exome Variant ServerCALCRL
ExAC (Exome Aggregation Consortium)CALCRL (select the gene name)
Genetic variants : HAPMAP10203
Genomic Variants (DGV)CALCRL [DGVbeta]
DECIPHERCALCRL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCALCRL 
Mutations
ICGC Data PortalCALCRL 
TCGA Data PortalCALCRL 
Broad Tumor PortalCALCRL
OASIS PortalCALCRL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCALCRL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCALCRL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CALCRL
DgiDB (Drug Gene Interaction Database)CALCRL
DoCM (Curated mutations)CALCRL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CALCRL (select a term)
intoGenCALCRL
Cancer3DCALCRL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114190   
Orphanet
MedgenCALCRL
Genetic Testing Registry CALCRL
NextProtQ16602 [Medical]
TSGene10203
GENETestsCALCRL
Target ValidationCALCRL
Huge Navigator CALCRL [HugePedia]
snp3D : Map Gene to Disease10203
BioCentury BCIQCALCRL
ClinGenCALCRL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10203
Chemical/Pharm GKB GenePA26033
Clinical trialCALCRL
Miscellaneous
canSAR (ICR)CALCRL (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCALCRL
EVEXCALCRL
GoPubMedCALCRL
iHOPCALCRL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:26:32 CEST 2017

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