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CAPN10 (calpain 10)

Identity

Other aliasCANP10
NIDDM1
HGNC (Hugo) CAPN10
LocusID (NCBI) 11132
Atlas_Id 49989
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 240586716 and ends at 240599109 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAPN10 (2q37.3) / CAPN10 (2q37.3)CAPN10 (2q37.3) / GPR35 (2q37.3)TMEM150A (2p11.2) / CAPN10 (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAPN10   1477
Cards
Entrez_Gene (NCBI)CAPN10  11132  calpain 10
AliasesCANP10; NIDDM1
GeneCards (Weizmann)CAPN10
Ensembl hg19 (Hinxton)ENSG00000142330 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142330 [Gene_View]  chr2:240586716-240599109 [Contig_View]  CAPN10 [Vega]
ICGC DataPortalENSG00000142330
TCGA cBioPortalCAPN10
AceView (NCBI)CAPN10
Genatlas (Paris)CAPN10
WikiGenes11132
SOURCE (Princeton)CAPN10
Genetics Home Reference (NIH)CAPN10
Genomic and cartography
GoldenPath hg38 (UCSC)CAPN10  -     chr2:240586716-240599109 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAPN10  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblCAPN10 - 2q37.3 [CytoView hg19]  CAPN10 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBICAPN10 [Mapview hg19]  CAPN10 [Mapview hg38]
OMIM601283   605286   
Gene and transcription
Genbank (Entrez)AB058748 AF089088 AF089090 AF089091 AF089092
RefSeq transcript (Entrez)NM_021251 NM_023083 NM_023084 NM_023085 NM_023086 NM_023087 NM_023088 NM_023089
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAPN10
Cluster EST : UnigeneHs.728234 [ NCBI ]
CGAP (NCI)Hs.728234
Alternative Splicing GalleryENSG00000142330
Gene ExpressionCAPN10 [ NCBI-GEO ]   CAPN10 [ EBI - ARRAY_EXPRESS ]   CAPN10 [ SEEK ]   CAPN10 [ MEM ]
Gene Expression Viewer (FireBrowse)CAPN10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11132
GTEX Portal (Tissue expression)CAPN10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HC96   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HC96  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HC96
Splice isoforms : SwissVarQ9HC96
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   
PhosPhoSitePlusQ9HC96
Domaine pattern : Prosite (Expaxy)CALPAIN_CAT (PS50203)    THIOL_PROTEASE_CYS (PS00139)   
Domains : Interpro (EBI)C2_III    Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    CAPN10    Pept_cys_AS    Peptidase_C2_calpain_cat   
Domain families : Pfam (Sanger)Calpain_III (PF01067)    Peptidase_C2 (PF00648)   
Domain families : Pfam (NCBI)pfam01067    pfam00648   
Domain families : Smart (EMBL)calpain_III (SM00720)  CysPc (SM00230)  
Conserved Domain (NCBI)CAPN10
DMDM Disease mutations11132
Blocks (Seattle)CAPN10
SuperfamilyQ9HC96
Human Protein AtlasENSG00000142330
Peptide AtlasQ9HC96
HPRD05595
IPIIPI00302479   IPI00220233   IPI00183619   IPI00220234   IPI00253782   IPI00220235   IPI00220236   IPI00220238   IPI00893045   IPI00892527   IPI00892758   
Protein Interaction databases
DIP (DOE-UCLA)Q9HC96
IntAct (EBI)Q9HC96
FunCoupENSG00000142330
BioGRIDCAPN10
STRING (EMBL)CAPN10
ZODIACCAPN10
Ontologies - Pathways
QuickGOQ9HC96
Ontology : AmiGOSNARE binding  calcium-dependent cysteine-type endopeptidase activity  mitochondrion  cytosol  cytosol  plasma membrane  proteolysis  cellular component disassembly involved in execution phase of apoptosis  cytoskeletal protein binding  actin cytoskeleton reorganization  positive regulation of insulin secretion  positive regulation of intracellular transport  cellular response to insulin stimulus  positive regulation of glucose import  type B pancreatic cell apoptotic process  positive regulation of type B pancreatic cell apoptotic process  
Ontology : EGO-EBISNARE binding  calcium-dependent cysteine-type endopeptidase activity  mitochondrion  cytosol  cytosol  plasma membrane  proteolysis  cellular component disassembly involved in execution phase of apoptosis  cytoskeletal protein binding  actin cytoskeleton reorganization  positive regulation of insulin secretion  positive regulation of intracellular transport  cellular response to insulin stimulus  positive regulation of glucose import  type B pancreatic cell apoptotic process  positive regulation of type B pancreatic cell apoptotic process  
NDEx NetworkCAPN10
Atlas of Cancer Signalling NetworkCAPN10
Wikipedia pathwaysCAPN10
Orthology - Evolution
OrthoDB11132
GeneTree (enSembl)ENSG00000142330
Phylogenetic Trees/Animal Genes : TreeFamCAPN10
HOVERGENQ9HC96
HOGENOMQ9HC96
Homologs : HomoloGeneCAPN10
Homology/Alignments : Family Browser (UCSC)CAPN10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAPN10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAPN10
dbVarCAPN10
ClinVarCAPN10
1000_GenomesCAPN10 
Exome Variant ServerCAPN10
ExAC (Exome Aggregation Consortium)CAPN10 (select the gene name)
Genetic variants : HAPMAP11132
Genomic Variants (DGV)CAPN10 [DGVbeta]
DECIPHERCAPN10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAPN10 
Mutations
ICGC Data PortalCAPN10 
TCGA Data PortalCAPN10 
Broad Tumor PortalCAPN10
OASIS PortalCAPN10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAPN10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAPN10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CAPN10
DgiDB (Drug Gene Interaction Database)CAPN10
DoCM (Curated mutations)CAPN10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAPN10 (select a term)
intoGenCAPN10
Cancer3DCAPN10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601283    605286   
Orphanet
MedgenCAPN10
Genetic Testing Registry CAPN10
NextProtQ9HC96 [Medical]
TSGene11132
GENETestsCAPN10
Target ValidationCAPN10
Huge Navigator CAPN10 [HugePedia]
snp3D : Map Gene to Disease11132
BioCentury BCIQCAPN10
ClinGenCAPN10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11132
Chemical/Pharm GKB GenePA26058
Clinical trialCAPN10
Miscellaneous
canSAR (ICR)CAPN10 (select the gene name)
Probes
Litterature
PubMed154 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAPN10
EVEXCAPN10
GoPubMedCAPN10
iHOPCAPN10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:00:25 CEST 2017

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