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CAPN2 (calpain 2, (m/II) large subunit)

Identity

Other namesCANP2
CANPL2
CANPml
mCANP
HGNC (Hugo) CAPN2
LocusID (NCBI) 824
Location 1q41
Location_base_pair Starts at 223889295 and ends at 223963720 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CAPN2   1479
Cards
Entrez_Gene (NCBI)CAPN2  824  calpain 2, (m/II) large subunit
GeneCards (Weizmann)CAPN2
Ensembl (Hinxton)ENSG00000162909 [Gene_View]  chr1:223889295-223963720 [Contig_View]  CAPN2 [Vega]
AceView (NCBI)CAPN2
Genatlas (Paris)CAPN2
WikiGenes824
SOURCE (Princeton)NM_001146068 NM_001748
Genomic and cartography
GoldenPath (UCSC)CAPN2  -  1q41   chr1:223889295-223963720 +  1q41   [Description]    (hg19-Feb_2009)
EnsemblCAPN2 - 1q41 [CytoView]
Mapping of homologs : NCBICAPN2 [Mapview]
OMIM114230   
Gene and transcription
Genbank (Entrez)AB209855 AF261089 AI089162 AK023851 AK056838
RefSeq transcript (Entrez)NM_001146068 NM_001748
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_167186 NW_001838539 NW_004929294
Consensus coding sequences : CCDS (NCBI)CAPN2
Cluster EST : UnigeneHs.350899 [ NCBI ]
CGAP (NCI)Hs.350899
Alternative Splicing : Fast-db (Paris)GSHG0001469
Alternative Splicing GalleryENSG00000162909
Gene ExpressionCAPN2 [ NCBI-GEO ]     CAPN2 [ SEEK ]   CAPN2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17655 (Uniprot)
NextProtP17655  [Medical]
With graphics : InterProP17655
Splice isoforms : SwissVarP17655 (Swissvar)
Catalytic activity : Enzyme3.4.22.53 [ Enzyme-Expasy ]   3.4.22.533.4.22.53 [ IntEnz-EBI ]   3.4.22.53 [ BRENDA ]   3.4.22.53 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CALPAIN_CAT (PS50203)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (EBI)Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Pept_cys_AS    Peptidase_C2_calpain_cat   
Related proteins : CluSTrP17655
Domain families : Pfam (Sanger)Calpain_III (PF01067)    Peptidase_C2 (PF00648)   
Domain families : Pfam (NCBI)pfam01067    pfam00648   
Domain families : Smart (EMBL)calpain_III (SM00720)  CysPc (SM00230)  EFh (SM00054)  
DMDM Disease mutations824
Blocks (Seattle)P17655
PDB (SRS)1KFU    1KFX    2NQA   
PDB (PDBSum)1KFU    1KFX    2NQA   
PDB (IMB)1KFU    1KFX    2NQA   
PDB (RSDB)1KFU    1KFX    2NQA   
Human Protein AtlasENSG00000162909
Peptide AtlasP17655
HPRD00254
IPIIPI00289758   IPI01010797   IPI00902887   IPI00910745   IPI00446140   IPI00641266   
Protein Interaction databases
DIP (DOE-UCLA)P17655
IntAct (EBI)P17655
FunCoupENSG00000162909
BioGRIDCAPN2
InParanoidP17655
Interologous Interaction database P17655
IntegromeDBCAPN2
STRING (EMBL)CAPN2
Ontologies - Pathways
Ontology : AmiGOchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  plasma membrane  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein autoprocessing  dendrite  protein heterodimerization activity  cellular response to amino acid stimulus  
Ontology : EGO-EBIchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  plasma membrane  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein autoprocessing  dendrite  protein heterodimerization activity  cellular response to amino acid stimulus  
Pathways : BIOCARTAmCalpain and friends in Cell motility [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]   
Pathways : KEGGProtein processing in endoplasmic reticulum    Apoptosis    Focal adhesion    Alzheimer's disease   
REACTOMECAPN2
Protein Interaction DatabaseCAPN2
Wikipedia pathwaysCAPN2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CAPN2
SNP (GeneSNP Utah)CAPN2
SNP : HGBaseCAPN2
Genetic variants : HAPMAPCAPN2
1000_GenomesCAPN2 
ICGC programENSG00000162909 
Somatic Mutations in Cancer : COSMICCAPN2 
CONAN: Copy Number AnalysisCAPN2 
Mutations and Diseases : HGMDCAPN2
OMIM114230   
GENETestsCAPN2
Disease Genetic AssociationCAPN2
Huge Navigator CAPN2 [HugePedia]  CAPN2 [HugeCancerGEM]
Genomic VariantsCAPN2  CAPN2 [DGVbeta]
Exome VariantCAPN2
dbVarCAPN2
ClinVarCAPN2
snp3D : Map Gene to Disease824
General knowledge
Homologs : HomoloGeneCAPN2
Homology/Alignments : Family Browser (UCSC)CAPN2
Phylogenetic Trees/Animal Genes : TreeFamCAPN2
Chemical/Protein Interactions : CTD824
Chemical/Pharm GKB GenePA26060
Clinical trialCAPN2
Cancer Resource (Charite)ENSG00000162909
Other databases
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
CoreMineCAPN2
iHOPCAPN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:12:27 CEST 2014

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