Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CAPN2 (calpain 2, (m/II) large subunit)

Identity

Other namesCANP2
CANPL2
CANPml
mCANP
HGNC (Hugo) CAPN2
LocusID (NCBI) 824
Location 1q41
Location_base_pair Starts at 223889295 and ends at 223963720 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CAPN2   1479
Entrez_Gene (NCBI)CAPN2  824  calpain 2, (m/II) large subunit
Cards
GeneCards (Weizmann)CAPN2
Ensembl (Hinxton)ENSG00000162909 [Gene_View]  chr1:223889295-223963720 [Contig_View]  CAPN2 [Vega]
AceView (NCBI)CAPN2
Genatlas (Paris)CAPN2
SOURCE (Stanford)NM_001146068 NM_001748
Genomic and cartography
GoldenPath (UCSC)CAPN2  -  1q41   chr1:223889295-223963720 +  1q41   [Description]    (hg19-Feb_2009)
EnsemblCAPN2 - 1q41 [CytoView]
Mapping of homologs : NCBICAPN2 [Mapview]
OMIM114230   
Gene and transcription
Genbank (Entrez)AB209855 AF261089 AI089162 AK023851 AK056838
RefSeq transcript (SRS)NM_001146068 NM_001748
RefSeq transcript (Entrez)NM_001146068 NM_001748
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NT_167186 NW_001838539 NW_004078000
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_167186 NW_001838539 NW_004078000
Consensus coding sequences : CCDS (NCBI)CAPN2
Cluster EST : UnigeneHs.350899 [ SRS ] Hs.350899 [ NCBI ]
CGAP (NCI)Hs.350899
Alternative Splicing : Fast-db (Paris)GSHG0001469
Alternative Splicing GalleryENSG00000162909
Gene ExpressionCAPN2 [ NCBI-GEO ]   CAPN2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17655 (SRS) P17655 (Uniprot)
NextProtP17655
With graphics : InterProP17655
Splice isoforms : SwissVarP17655(Swissvar)
Domaine pattern : Prosite (SRS)CALPAIN_CAT (PS50203)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domaine pattern : Prosite (Expaxy)CALPAIN_CAT (PS50203)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    THIOL_PROTEASE_ASN (PS00640)    THIOL_PROTEASE_CYS (PS00139)    THIOL_PROTEASE_HIS (PS00639)   
Domains : Interpro (SRS)Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    EF-hand-like_dom    EF_Hand_1_Ca_BS    EF_HAND_2    EF_hand_Ca-bd    Pept_cys_AS    Peptidase_C2_calpain_cat   
Domains : Interpro (EBI)Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    EF-hand-like_dom    EF_Hand_1_Ca_BS    EF_HAND_2    EF_hand_Ca-bd    Pept_cys_AS    Peptidase_C2_calpain_cat   
Related proteins : CluSTrP17655
Domain families : Pfam (SRS)Calpain_III (PF01067)    Peptidase_C2 (PF00648)   
Domain families : Pfam (Sanger)Calpain_III (PF01067)    Peptidase_C2 (PF00648)   
Domain families : Pfam (NCBI)pfam01067    pfam00648   
Domain families : Smart (EMBL)calpain_III (SM00720)  CysPc (SM00230)  EFh (SM00054)  
DMDM824
Blocks (Seattle)P17655
PDB (SRS)1KFU    1KFX    2NQA   
PDB (PDBSum)1KFU    1KFX    2NQA   
PDB (IMB)1KFU    1KFX    2NQA   
PDB (RSDB)1KFU    1KFX    2NQA   
Human Protein AtlasENSG00000162909
HPRD00254
IPIIPI00289758   IPI01010797   IPI00902887   IPI00910745   IPI00446140   IPI00641266   
Protein Interaction databases
DIP (DOE-UCLA)P17655
IntAct (EBI)P17655
FunCoupENSG00000162909
REACTOMECAPN2
Protein Interaction Database824
BioGRIDCAPN2
InParanoidP17655
Interologous Interaction database P17655
IntegromeDBCAPN2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CAPN2
SNP (GeneSNP Utah)CAPN2
SNP : HGBaseCAPN2
Genetic variants : HAPMAPCAPN2
Somatic Mutations in Cancer : COSMICCAPN2 
CONAN: Copy Number AnalysisCAPN2 
Mutations and Diseases : HGMDCAPN2
OMIM114230   
GENETests114230   
Disease Genetic AssociationCAPN2
Huge Navigator CAPN2 [HugePedia]  CAPN2 [HugeCancerGEM]
Genomic VariantsCAPN2  CAPN2 [DGVbeta]
snp3D : Map Gene to Disease824
General knowledge
Homologs : HomoloGeneCAPN2
Homology/Alignments : Family Browser (UCSC)CAPN2
Phylogenetic Trees/Animal Genes : TreeFamCAPN2
Catalytic activity : Enzyme3.4.22.53 [ Enzyme-Expasy ]   3.4.22.53 [ Enzyme-SRS ]   3.4.22.53 [ IntEnz-EBI ]   3.4.22.53 [ BRENDA ]   3.4.22.53 [ KEGG ]   
Chemical/Protein Interactions : CTD824
Chemical/Pharm GKB GenePA26060
Clinical trialCAPN2
Cancer Resource (Charite)ENSG00000162909
Ontology : AmiGOchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  plasma membrane  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein heterodimerization activity  
Ontology : EGO-EBIchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  plasma membrane  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein heterodimerization activity  
Pathways : BIOCARTAmCalpain and friends in Cell motility [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]   
Pathways : KEGGApoptosisFocal adhesion
Other databases
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
PubGeneCAPN2
iHOPCAPN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:23:33 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.