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CAPN2 (calpain 2)

Identity

Other namesCANP2
CANPL2
CANPml
mCANP
HGNC (Hugo) CAPN2
LocusID (NCBI) 824
Atlas_Id 45566
Location 1q41  [Link to chromosome band 1q41]
Location_base_pair Starts at 223889295 and ends at 223963720 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CAPN2 (1q41) / CAPN2 (1q41)CAPN2 (1q41) / LAPTM4A (2p24.1)CAPN2 (1q41) / SMARCA1 (Xq25)
CAPN2 (1q41) / ZNF32-AS3 (10q11.21)CAPN2 1q41 / SMARCA1 Xq25

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAPN2   1479
Cards
Entrez_Gene (NCBI)CAPN2  824  calpain 2
AliasesCANP2; CANPL2; CANPml; mCANP
GeneCards (Weizmann)CAPN2
Ensembl hg19 (Hinxton)ENSG00000162909 [Gene_View]  chr1:223889295-223963720 [Contig_View]  CAPN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000162909 [Gene_View]  chr1:223889295-223963720 [Contig_View]  CAPN2 [Vega]
ICGC DataPortalENSG00000162909
TCGA cBioPortalCAPN2
AceView (NCBI)CAPN2
Genatlas (Paris)CAPN2
WikiGenes824
SOURCE (Princeton)CAPN2
Genomic and cartography
GoldenPath hg19 (UCSC)CAPN2  -     chr1:223889295-223963720 +  1q41   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CAPN2  -     1q41   [Description]    (hg38-Dec_2013)
EnsemblCAPN2 - 1q41 [CytoView hg19]  CAPN2 - 1q41 [CytoView hg38]
Mapping of homologs : NCBICAPN2 [Mapview hg19]  CAPN2 [Mapview hg38]
OMIM114230   
Gene and transcription
Genbank (Entrez)AB209855 AF261089 AI089162 AK023851 AK055046
RefSeq transcript (Entrez)NM_001146068 NM_001748
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)CAPN2
Cluster EST : UnigeneHs.350899 [ NCBI ]
CGAP (NCI)Hs.350899
Alternative Splicing GalleryENSG00000162909
Gene ExpressionCAPN2 [ NCBI-GEO ]   CAPN2 [ EBI - ARRAY_EXPRESS ]   CAPN2 [ SEEK ]   CAPN2 [ MEM ]
Gene Expression Viewer (FireBrowse)CAPN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)824
GTEX Portal (Tissue expression)CAPN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17655 (Uniprot)
NextProtP17655  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17655
Splice isoforms : SwissVarP17655 (Swissvar)
Catalytic activity : Enzyme3.4.22.53 [ Enzyme-Expasy ]   3.4.22.533.4.22.53 [ IntEnz-EBI ]   3.4.22.53 [ BRENDA ]   3.4.22.53 [ KEGG ]   
PhosPhoSitePlusP17655
Domaine pattern : Prosite (Expaxy)CALPAIN_CAT (PS50203)    EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    THIOL_PROTEASE_CYS (PS00139)   
Domains : Interpro (EBI)Calpain_cysteine_protease    Calpain_domain_III    Calpain_III    CAPN2    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    Pept_cys_AS    Peptidase_C2_calpain_cat   
Domain families : Pfam (Sanger)Calpain_III (PF01067)    EF-hand_8 (PF13833)    Peptidase_C2 (PF00648)   
Domain families : Pfam (NCBI)pfam01067    pfam13833    pfam00648   
Domain families : Smart (EMBL)calpain_III (SM00720)  CysPc (SM00230)  EFh (SM00054)  
DMDM Disease mutations824
Blocks (Seattle)CAPN2
PDB (SRS)1KFU    1KFX    2NQA   
PDB (PDBSum)1KFU    1KFX    2NQA   
PDB (IMB)1KFU    1KFX    2NQA   
PDB (RSDB)1KFU    1KFX    2NQA   
Structural Biology KnowledgeBase1KFU    1KFX    2NQA   
SCOP (Structural Classification of Proteins)1KFU    1KFX    2NQA   
CATH (Classification of proteins structures)1KFU    1KFX    2NQA   
SuperfamilyP17655
Human Protein AtlasENSG00000162909
Peptide AtlasP17655
HPRD00254
IPIIPI00289758   IPI01010797   IPI00902887   IPI00910745   IPI00446140   IPI00641266   
Protein Interaction databases
DIP (DOE-UCLA)P17655
IntAct (EBI)P17655
FunCoupENSG00000162909
BioGRIDCAPN2
STRING (EMBL)CAPN2
ZODIACCAPN2
Ontologies - Pathways
QuickGOP17655
Ontology : AmiGOchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  cytoplasm  lysosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  plasma membrane  focal adhesion  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein autoprocessing  extracellular matrix disassembly  dendrite  cortical actin cytoskeleton  pseudopodium  membrane raft  membrane raft  protein heterodimerization activity  regulation of cytoskeleton organization  proteolysis involved in cellular protein catabolic process  extracellular exosome  cellular response to amino acid stimulus  perinuclear endoplasmic reticulum  
Ontology : EGO-EBIchromatin  response to hypoxia  blastocyst development  calcium-dependent cysteine-type endopeptidase activity  calcium-dependent cysteine-type endopeptidase activity  calcium ion binding  protein binding  nucleus  cytoplasm  cytoplasm  lysosome  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  plasma membrane  focal adhesion  proteolysis  myoblast fusion  cytoskeletal protein binding  cysteine-type peptidase activity  protein autoprocessing  extracellular matrix disassembly  dendrite  cortical actin cytoskeleton  pseudopodium  membrane raft  membrane raft  protein heterodimerization activity  regulation of cytoskeleton organization  proteolysis involved in cellular protein catabolic process  extracellular exosome  cellular response to amino acid stimulus  perinuclear endoplasmic reticulum  
Pathways : BIOCARTAmCalpain and friends in Cell motility [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]   
Pathways : KEGGProtein processing in endoplasmic reticulum    Apoptosis    Focal adhesion    Alzheimer's disease   
NDEx NetworkCAPN2
Atlas of Cancer Signalling NetworkCAPN2
Wikipedia pathwaysCAPN2
Orthology - Evolution
OrthoDB824
GeneTree (enSembl)ENSG00000162909
Phylogenetic Trees/Animal Genes : TreeFamCAPN2
Homologs : HomoloGeneCAPN2
Homology/Alignments : Family Browser (UCSC)CAPN2
Gene fusions - Rearrangements
Fusion: TCGACAPN2 1q41 SMARCA1 Xq25 PRAD
Polymorphisms : SNP, variants
NCBI Variation ViewerCAPN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAPN2
dbVarCAPN2
ClinVarCAPN2
1000_GenomesCAPN2 
Exome Variant ServerCAPN2
ExAC (Exome Aggregation Consortium)CAPN2 (select the gene name)
Genetic variants : HAPMAP824
Genomic Variants (DGV)CAPN2 [DGVbeta]
Mutations
ICGC Data PortalCAPN2 
TCGA Data PortalCAPN2 
Broad Tumor PortalCAPN2
OASIS PortalCAPN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAPN2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAPN2
DgiDB (Drug Gene Interaction Database)CAPN2
DoCM (Curated mutations)CAPN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAPN2 (select a term)
intoGenCAPN2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:223889295-223963720  ENSG00000162909
CONAN: Copy Number AnalysisCAPN2 
Mutations and Diseases : HGMDCAPN2
OMIM114230   
MedgenCAPN2
Genetic Testing Registry CAPN2
NextProtP17655 [Medical]
TSGene824
GENETestsCAPN2
Huge Navigator CAPN2 [HugePedia]
snp3D : Map Gene to Disease824
BioCentury BCIQCAPN2
ClinGenCAPN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD824
Chemical/Pharm GKB GenePA26060
Clinical trialCAPN2
Miscellaneous
canSAR (ICR)CAPN2 (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAPN2
EVEXCAPN2
GoPubMedCAPN2
iHOPCAPN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:40:00 CEST 2016

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