CASP14 (caspase 14)

2003-08-01  

Identity

HGNC
LOCATION
19p13.12
LOCUSID
ALIAS
ARCI12
FUSION GENES

Other Information

Locus ID:

NCBI: 23581
MIM: 605848
HGNC: 1502
Ensembl: ENSG00000105141

Variants:

dbSNP: 23581
ClinVar: 23581
TCGA: ENSG00000105141
COSMIC: CASP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105141ENST00000427043P31944
ENSG00000105141ENST00000427043B2CIS9

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
219307822011Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.46
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
124452052002Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner.24
194148602009Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies.19
160618622005Tumor-associated alterations in caspase-14 expression in epithelial malignancies.18
215396192011Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines--a possible link between reduced skin barrier function and inflammation?13
153314082004Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.12
195730802009Common genetic variants in candidate genes and risk of familial lymphoid malignancies.12
205338282010New role for LEKTI in skin barrier formation: label-free quantitative proteomic identification of caspase 14 as a novel target for the protease inhibitor LEKTI.11
122001342002Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.9

Citation

Dessen P

CASP14 (caspase 14)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/918/casp14