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CASP14 (caspase 14)

Identity

Alias_namescaspase 14, apoptosis-related cysteine protease
caspase 14, apoptosis-related cysteine peptidase
Alias_symbol (synonym)MICE
MGC119078
MGC119079
Other aliasARCI12
HGNC (Hugo) CASP14
LocusID (NCBI) 23581
Atlas_Id 918
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 15049480 and ends at 15058292 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CASP14 (19p13.12) / ECT2 (3q26.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASP14   1502
Cards
Entrez_Gene (NCBI)CASP14  23581  caspase 14
AliasesARCI12
GeneCards (Weizmann)CASP14
Ensembl hg19 (Hinxton)ENSG00000105141 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105141 [Gene_View]  chr19:15049480-15058292 [Contig_View]  CASP14 [Vega]
ICGC DataPortalENSG00000105141
TCGA cBioPortalCASP14
AceView (NCBI)CASP14
Genatlas (Paris)CASP14
WikiGenes23581
SOURCE (Princeton)CASP14
Genetics Home Reference (NIH)CASP14
Genomic and cartography
GoldenPath hg38 (UCSC)CASP14  -     chr19:15049480-15058292 +  19p13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CASP14  -     19p13.12   [Description]    (hg19-Feb_2009)
EnsemblCASP14 - 19p13.12 [CytoView hg19]  CASP14 - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBICASP14 [Mapview hg19]  CASP14 [Mapview hg38]
OMIM605848   617320   
Gene and transcription
Genbank (Entrez)AF097874 AK313992 BC069541 BC103868 BC103869
RefSeq transcript (Entrez)NM_012114
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CASP14
Cluster EST : UnigeneHs.466057 [ NCBI ]
CGAP (NCI)Hs.466057
Alternative Splicing GalleryENSG00000105141
Gene ExpressionCASP14 [ NCBI-GEO ]   CASP14 [ EBI - ARRAY_EXPRESS ]   CASP14 [ SEEK ]   CASP14 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23581
GTEX Portal (Tissue expression)CASP14
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31944   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31944  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31944
Splice isoforms : SwissVarP31944
Catalytic activity : Enzyme3.4.22.- [ Enzyme-Expasy ]   3.4.22.-3.4.22.- [ IntEnz-EBI ]   3.4.22.- [ BRENDA ]   3.4.22.- [ KEGG ]   
PhosPhoSitePlusP31944
Domaine pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)Caspase-14    Caspase-like_dom    Caspase_cys_AS    Pept_C14_p10    Pept_C14_p20    Pept_C14A   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)CASc (SM00115)  
Conserved Domain (NCBI)CASP14
DMDM Disease mutations23581
Blocks (Seattle)CASP14
SuperfamilyP31944
Human Protein AtlasENSG00000105141
Peptide AtlasP31944
HPRD05788
IPIIPI00013885   
Protein Interaction databases
DIP (DOE-UCLA)P31944
IntAct (EBI)P31944
FunCoupENSG00000105141
BioGRIDCASP14
STRING (EMBL)CASP14
ZODIACCASP14
Ontologies - Pathways
QuickGOP31944
Ontology : AmiGOendopeptidase activity  cysteine-type endopeptidase activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  proteolysis  epidermis development  extracellular matrix  keratinization  keratin filament  extracellular exosome  cornification  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Ontology : EGO-EBIendopeptidase activity  cysteine-type endopeptidase activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  proteolysis  epidermis development  extracellular matrix  keratinization  keratin filament  extracellular exosome  cornification  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
NDEx NetworkCASP14
Atlas of Cancer Signalling NetworkCASP14
Wikipedia pathwaysCASP14
Orthology - Evolution
OrthoDB23581
GeneTree (enSembl)ENSG00000105141
Phylogenetic Trees/Animal Genes : TreeFamCASP14
HOVERGENP31944
HOGENOMP31944
Homologs : HomoloGeneCASP14
Homology/Alignments : Family Browser (UCSC)CASP14
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASP14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP14
dbVarCASP14
ClinVarCASP14
1000_GenomesCASP14 
Exome Variant ServerCASP14
ExAC (Exome Aggregation Consortium)CASP14 (select the gene name)
Genetic variants : HAPMAP23581
Genomic Variants (DGV)CASP14 [DGVbeta]
DECIPHERCASP14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCASP14 
Mutations
ICGC Data PortalCASP14 
TCGA Data PortalCASP14 
Broad Tumor PortalCASP14
OASIS PortalCASP14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCASP14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASP14
DgiDB (Drug Gene Interaction Database)CASP14
DoCM (Curated mutations)CASP14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP14 (select a term)
intoGenCASP14
Cancer3DCASP14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605848    617320   
Orphanet
MedgenCASP14
Genetic Testing Registry CASP14
NextProtP31944 [Medical]
TSGene23581
GENETestsCASP14
Huge Navigator CASP14 [HugePedia]
snp3D : Map Gene to Disease23581
BioCentury BCIQCASP14
ClinGenCASP14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23581
Chemical/Pharm GKB GenePA26085
Clinical trialCASP14
Miscellaneous
canSAR (ICR)CASP14 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP14
EVEXCASP14
GoPubMedCASP14
iHOPCASP14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:08:57 CEST 2017

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