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CBR1 (carbonyl reductase 1)

Identity

Alias_namesmember 1
CBR
Alias_symbol (synonym)SDR21C1
Other aliashCBR1
HGNC (Hugo) CBR1
LocusID (NCBI) 873
Atlas_Id 50526
Location 21q22.12  [Link to chromosome band 21q22]
Location_base_pair Starts at 36069924 and ends at 36073177 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CBR1   1548
Cards
Entrez_Gene (NCBI)CBR1  873  carbonyl reductase 1
AliasesCBR; SDR21C1; hCBR1
GeneCards (Weizmann)CBR1
Ensembl hg19 (Hinxton)ENSG00000159228 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159228 [Gene_View]  chr21:36069924-36073177 [Contig_View]  CBR1 [Vega]
ICGC DataPortalENSG00000159228
TCGA cBioPortalCBR1
AceView (NCBI)CBR1
Genatlas (Paris)CBR1
WikiGenes873
SOURCE (Princeton)CBR1
Genetics Home Reference (NIH)CBR1
Genomic and cartography
GoldenPath hg38 (UCSC)CBR1  -     chr21:36069924-36073177 +  21q22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CBR1  -     21q22.12   [Description]    (hg19-Feb_2009)
EnsemblCBR1 - 21q22.12 [CytoView hg19]  CBR1 - 21q22.12 [CytoView hg38]
Mapping of homologs : NCBICBR1 [Mapview hg19]  CBR1 [Mapview hg38]
OMIM114830   
Gene and transcription
Genbank (Entrez)AB124848 AK294142 AK308691 AK311219 AK314879
RefSeq transcript (Entrez)NM_001286789 NM_001757
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CBR1
Cluster EST : UnigeneHs.88778 [ NCBI ]
CGAP (NCI)Hs.88778
Alternative Splicing GalleryENSG00000159228
Gene ExpressionCBR1 [ NCBI-GEO ]   CBR1 [ EBI - ARRAY_EXPRESS ]   CBR1 [ SEEK ]   CBR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CBR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)873
GTEX Portal (Tissue expression)CBR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16152   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16152  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16152
Splice isoforms : SwissVarP16152
Catalytic activity : Enzyme1.1.1.184 [ Enzyme-Expasy ]   1.1.1.1841.1.1.184 [ IntEnz-EBI ]   1.1.1.184 [ BRENDA ]   1.1.1.184 [ KEGG ]   
PhosPhoSitePlusP16152
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)NAD(P)-bd_dom    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)CBR1
DMDM Disease mutations873
Blocks (Seattle)CBR1
PDB (SRS)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
PDB (PDBSum)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
PDB (IMB)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
PDB (RSDB)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
Structural Biology KnowledgeBase1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
SCOP (Structural Classification of Proteins)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
CATH (Classification of proteins structures)1WMA    2PFG    3BHI    3BHJ    3BHM    4Z3D   
SuperfamilyP16152
Human Protein AtlasENSG00000159228
Peptide AtlasP16152
HPRD00267
IPIIPI00295386   IPI00795334   IPI00909888   IPI00974490   
Protein Interaction databases
DIP (DOE-UCLA)P16152
IntAct (EBI)P16152
FunCoupENSG00000159228
BioGRIDCBR1
STRING (EMBL)CBR1
ZODIACCBR1
Ontologies - Pathways
QuickGOP16152
Ontology : AmiGOcarbonyl reductase (NADPH) activity  cytosol  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  drug metabolic process  cyclooxygenase pathway  epithelial cell differentiation  vitamin K metabolic process  15-hydroxyprostaglandin dehydrogenase (NADP+) activity  prostaglandin-E2 9-reductase activity  oxidation-reduction process  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBIcarbonyl reductase (NADPH) activity  cytosol  oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor  drug metabolic process  cyclooxygenase pathway  epithelial cell differentiation  vitamin K metabolic process  15-hydroxyprostaglandin dehydrogenase (NADP+) activity  prostaglandin-E2 9-reductase activity  oxidation-reduction process  extracellular exosome  extracellular vesicle  
Pathways : KEGGArachidonic acid metabolism    Metabolism of xenobiotics by cytochrome P450    Chemical carcinogenesis   
NDEx NetworkCBR1
Atlas of Cancer Signalling NetworkCBR1
Wikipedia pathwaysCBR1
Orthology - Evolution
OrthoDB873
GeneTree (enSembl)ENSG00000159228
Phylogenetic Trees/Animal Genes : TreeFamCBR1
HOVERGENP16152
HOGENOMP16152
Homologs : HomoloGeneCBR1
Homology/Alignments : Family Browser (UCSC)CBR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCBR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CBR1
dbVarCBR1
ClinVarCBR1
1000_GenomesCBR1 
Exome Variant ServerCBR1
ExAC (Exome Aggregation Consortium)CBR1 (select the gene name)
Genetic variants : HAPMAP873
Genomic Variants (DGV)CBR1 [DGVbeta]
DECIPHERCBR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCBR1 
Mutations
ICGC Data PortalCBR1 
TCGA Data PortalCBR1 
Broad Tumor PortalCBR1
OASIS PortalCBR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCBR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCBR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CBR1
DgiDB (Drug Gene Interaction Database)CBR1
DoCM (Curated mutations)CBR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CBR1 (select a term)
intoGenCBR1
Cancer3DCBR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114830   
Orphanet
MedgenCBR1
Genetic Testing Registry CBR1
NextProtP16152 [Medical]
TSGene873
GENETestsCBR1
Target ValidationCBR1
Huge Navigator CBR1 [HugePedia]
snp3D : Map Gene to Disease873
BioCentury BCIQCBR1
ClinGenCBR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD873
Chemical/Pharm GKB GenePA26121
Clinical trialCBR1
Miscellaneous
canSAR (ICR)CBR1 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCBR1
EVEXCBR1
GoPubMedCBR1
iHOPCBR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:48:49 CEST 2017

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