CCAR1 (cell division cycle and apoptosis regulator 1)

2007-08-01 Affiliation

Identity

HGNC

CCAR1

LOCATION

10q21.3

LOCUSID

55749

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55749
MIM: 612569
HGNC: 24236
Ensembl: ENSG00000060339

Variants:

dbSNP: 55749
ClinVar: 55749
TCGA: ENSG00000060339
COSMIC: CCAR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000060339	ENST00000265872	Q8IX12
ENSG00000060339	ENST00000479143	H0YFT7
ENSG00000060339	ENST00000494903	F5H808
ENSG00000060339	ENST00000536012	F5H1H2
ENSG00000060339	ENST00000536391	F5H3I8
ENSG00000060339	ENST00000538031	F5H7M9
ENSG00000060339	ENST00000539539	A0A0C4DGG8
ENSG00000060339	ENST00000540210	F5H3E1
ENSG00000060339	ENST00000541012	F5H3E1
ENSG00000060339	ENST00000543225	F5H2E6
ENSG00000060339	ENST00000543229	F5H1L3
ENSG00000060339	ENST00000543706	H0YFJ7
ENSG00000060339	ENST00000543719	Q8IX12
ENSG00000060339	ENST00000630771	F5H3E1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18722177	2008	CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.	73
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
12816952	2003	Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.	40
16543231	2006	Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor.	36
18321953	2008	Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.	35
19520846	2009	Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells.	31
19073175	2009	Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules.	29
31281495	2019	Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.	22
21903591	2011	Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis.	21
17513614	2007	Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of human breast cancer cells in vitro and in vivo.	18

Citation

Dessen P

CCAR1 (cell division cycle and apoptosis regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47696/ccar1