CCL2 (C-C motif chemokine ligand 2)

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CCL2 (C-C motif chemokine ligand 2)

Identity

Alias (NCBI)	GDCF-2
	HC11
	HSMCR30
	MCAF
	MCP-1
	MCP1
	SCYA2
	SMC-CF
HGNC (Hugo)	CCL2
HGNC Alias symb	MCP1
	MCP-1
	MCAF
	SMC-CF
	GDCF-2
	HC11
	MGC9434
HGNC Alias name	monocyte chemotactic protein 1, homologous to mouse Sig-je
	monocyte chemoattractant protein-1
	monocyte chemotactic and activating factor
	monocyte secretory protein JE
	small inducible cytokine subfamily A (Cys-Cys), member 2
HGNC Previous name	SCYA2
HGNC Previous name	small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
	chemokine (C-C motif) ligand 2
LocusID (NCBI)	6347
Atlas_Id	942
Location	17q12 [Link to chromosome band 17q12]
Location_base_pair	Starts at 34255285 and ends at 34257201 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

TAOK1 (17q11.2) / CCL2 (17q12)

TAOK1 17q11.2 / CCL2 17q12

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CCL2 10618
	Cards
Entrez_Gene (NCBI)	CCL2 C-C motif chemokine ligand 2
Aliases	GDCF-2; HC11; HSMCR30; MCAF;
	MCP-1; MCP1; SCYA2; SMC-CF
GeneCards (Weizmann)	CCL2
Ensembl hg19 (Hinxton)	ENSG00000108691 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000108691 [Gene_View] ENSG00000108691 [Sequence] chr17:34255285-34257201 [Contig_View] CCL2 [Vega]
ICGC DataPortal	ENSG00000108691
TCGA cBioPortal	CCL2
AceView (NCBI)	CCL2
Genatlas (Paris)	CCL2
SOURCE (Princeton)	CCL2
Genetics Home Reference (NIH)	CCL2
	Genomic and cartography
GoldenPath hg38 (UCSC)	CCL2 - chr17:34255285-34257201 + 17q12 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	CCL2 - 17q12 [Description] (hg19-Feb_2009)
GoldenPath	CCL2 - 17q12 [CytoView hg19] CCL2 - 17q12 [CytoView hg38]
ImmunoBase	ENSG00000108691
Genome Data Viewer NCBI	CCL2 [Mapview hg19]
OMIM	158105 182940 607948 609423
	Gene and transcription
Genbank (Entrez)	AK311960 AV733621 BC009716 BG530064 BT007329
RefSeq transcript (Entrez)	NM_002982
Consensus coding sequences : CCDS (NCBI)	CCL2
Gene Expression	CCL2 [ NCBI-GEO ] CCL2 [ EBI - ARRAY_EXPRESS ] CCL2 [ SEEK ] CCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)	CCL2 [ Firebrowse - Broad ]
Genevisible	Expression of CCL2 in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	6347
GTEX Portal (Tissue expression)	CCL2
Human Protein Atlas	ENSG00000108691-CCL2 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P13500 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P13500 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P13500
PhosPhoSitePlus	P13500
Domaine pattern : Prosite (Expaxy)	SMALL_CYTOKINES_CC (PS00472)
Domains : Interpro (EBI)	Chemokine_b/g/d Chemokine_CC_CS Chemokine_IL8-like_dom Interleukin_8-like_sf
Domain families : Pfam (Sanger)	IL8 (PF00048)
Domain families : Pfam (NCBI)	pfam00048
Domain families : Smart (EMBL)	SCY (SM00199)
Conserved Domain (NCBI)	CCL2
PDB (RSDB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB Europe	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB (PDBSum)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB (IMB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
Structural Biology KnowledgeBase	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
SCOP (Structural Classification of Proteins)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
CATH (Classification of proteins structures)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
Superfamily	P13500
AlphaFold pdb e-kb	P13500
Human Protein Atlas [tissue]	ENSG00000108691-CCL2 [tissue]
HPRD	01149
	Protein Interaction databases
DIP (DOE-UCLA)	P13500
IntAct (EBI)	P13500
BioGRID	CCL2
STRING (EMBL)	CCL2
ZODIAC	CCL2
	Ontologies - Pathways
QuickGO	P13500
Ontology : AmiGO	MAPK cascade angiogenesis monocyte chemotaxis monocyte chemotaxis protein kinase activity signaling receptor binding protein binding extracellular region extracellular region extracellular space protein phosphorylation chemotaxis inflammatory response inflammatory response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger receptor signaling pathway via JAK-STAT chemokine activity regulation of cell shape response to bacterium animal organ morphogenesis viral genome replication cytokine-mediated signaling pathway cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process helper T cell extravasation PERK-mediated unfolded protein response protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration cellular response to fibroblast growth factor stimulus CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of synaptic transmission, glutamatergic chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import positive regulation of NMDA glutamate receptor activity negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Ontology : EGO-EBI	MAPK cascade angiogenesis monocyte chemotaxis monocyte chemotaxis protein kinase activity signaling receptor binding protein binding extracellular region extracellular region extracellular space protein phosphorylation chemotaxis inflammatory response inflammatory response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger receptor signaling pathway via JAK-STAT chemokine activity regulation of cell shape response to bacterium animal organ morphogenesis viral genome replication cytokine-mediated signaling pathway cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis neutrophil chemotaxis lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding negative regulation of glial cell apoptotic process helper T cell extravasation PERK-mediated unfolded protein response protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration cellular response to fibroblast growth factor stimulus CCR chemokine receptor binding eosinophil chemotaxis macrophage chemotaxis lymphocyte chemotaxis positive regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process positive regulation of synaptic transmission, glutamatergic chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of calcium ion import positive regulation of NMDA glutamate receptor activity negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Pathways : BIOCARTA	Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes] Msp/Ron Receptor Signaling Pathway [Genes] Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction Chemokine signaling pathway NOD-like receptor signaling pathway TNF signaling pathway Chagas disease (American trypanosomiasis) Malaria Influenza A Herpes simplex infection Rheumatoid arthritis
NDEx Network	CCL2
Atlas of Cancer Signalling Network	CCL2
Wikipedia pathways	CCL2
	Orthology - Evolution
OrthoDB	6347
GeneTree (enSembl)	ENSG00000108691
Phylogenetic Trees/Animal Genes : TreeFam	CCL2
Homologs : HomoloGene	CCL2
Homology/Alignments : Family Browser (UCSC)	CCL2
	Gene fusions - Rearrangements
Fusion : Mitelman	TAOK1/CCL2 [17q11.2/17q12]
Fusion : Quiver	CCL2
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	CCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CCL2
dbVar	CCL2
ClinVar	CCL2
Monarch	CCL2
1000_Genomes	CCL2
Exome Variant Server	CCL2
GNOMAD Browser	ENSG00000108691
Varsome Browser	CCL2
ACMG	CCL2 variants
Varity	P13500
Genomic Variants (DGV)	CCL2 [DGVbeta]
DECIPHER	CCL2 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	CCL2
	Mutations
ICGC Data Portal	CCL2
TCGA Data Portal	CCL2
Broad Tumor Portal	CCL2
OASIS Portal	CCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	CCL2 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	CCL2
Mutations and Diseases : HGMD	CCL2
LOVD (Leiden Open Variation Database)	[gene] [transcripts] [variants]
BioMuta	CCL2
DgiDB (Drug Gene Interaction Database)	CCL2
DoCM (Curated mutations)	CCL2
CIViC (Clinical Interpretations of Variants in Cancer)	CCL2
Cancer3D	CCL2
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	158105 182940 607948 609423
Orphanet
DisGeNET	CCL2
Medgen	CCL2
Genetic Testing Registry	CCL2
NextProt	P13500 [Medical]
GENETests	CCL2
Target Validation	CCL2
Huge Navigator	CCL2 [HugePedia]
ClinGen	CCL2
	Clinical trials, drugs, therapy
MyCancerGenome	CCL2
Protein Interactions : CTD	CCL2
Pharm GKB Gene	PA130413151
Pharos	P13500
Clinical trial	CCL2
	Miscellaneous
canSAR (ICR)	CCL2
Harmonizome	CCL2
DataMed Index	CCL2
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
EVEX	CCL2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Oct 4 15:02:39 CEST 2021

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

CCL2 (C-C motif chemokine ligand 2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute