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CCL2 (C-C motif chemokine ligand 2)

Identity

Alias (NCBI)GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
HGNC (Hugo) CCL2
HGNC Alias symbMCP1
MCP-1
MCAF
SMC-CF
GDCF-2
HC11
MGC9434
HGNC Alias namemonocyte chemotactic protein 1, homologous to mouse Sig-je
 monocyte chemoattractant protein-1
 monocyte chemotactic and activating factor
 monocyte secretory protein JE
 small inducible cytokine subfamily A (Cys-Cys), member 2
HGNC Previous nameSCYA2
HGNC Previous namesmall inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
 chemokine (C-C motif) ligand 2
LocusID (NCBI) 6347
Atlas_Id 942
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34255285 and ends at 34257201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TAOK1 (17q11.2) / CCL2 (17q12)TAOK1 17q11.2 / CCL2 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CCL2   10618
Cards
Entrez_Gene (NCBI)CCL2    C-C motif chemokine ligand 2
AliasesGDCF-2; HC11; HSMCR30; MCAF; 
MCP-1; MCP1; SCYA2; SMC-CF
GeneCards (Weizmann)CCL2
Ensembl hg19 (Hinxton)ENSG00000108691 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108691 [Gene_View]  ENSG00000108691 [Sequence]  chr17:34255285-34257201 [Contig_View]  CCL2 [Vega]
ICGC DataPortalENSG00000108691
TCGA cBioPortalCCL2
AceView (NCBI)CCL2
Genatlas (Paris)CCL2
SOURCE (Princeton)CCL2
Genetics Home Reference (NIH)CCL2
Genomic and cartography
GoldenPath hg38 (UCSC)CCL2  -     chr17:34255285-34257201 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL2  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathCCL2 - 17q12 [CytoView hg19]  CCL2 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000108691
Genome Data Viewer NCBICCL2 [Mapview hg19]  
OMIM158105   182940   607948   609423   
Gene and transcription
Genbank (Entrez)AK311960 AV733621 BC009716 BG530064 BT007329
RefSeq transcript (Entrez)NM_002982
Consensus coding sequences : CCDS (NCBI)CCL2
Gene ExpressionCCL2 [ NCBI-GEO ]   CCL2 [ EBI - ARRAY_EXPRESS ]   CCL2 [ SEEK ]   CCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL2 [ Firebrowse - Broad ]
GenevisibleExpression of CCL2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6347
GTEX Portal (Tissue expression)CCL2
Human Protein AtlasENSG00000108691-CCL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13500   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13500  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13500
PhosPhoSitePlusP13500
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_b/g/d    Chemokine_CC_CS    Chemokine_IL8-like_dom    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL2
PDB (RSDB)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
PDB Europe1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
PDB (PDBSum)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
PDB (IMB)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
Structural Biology KnowledgeBase1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
SCOP (Structural Classification of Proteins)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
CATH (Classification of proteins structures)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4    4R8I    4ZK9   
SuperfamilyP13500
AlphaFold pdb e-kbP13500   
Human Protein Atlas [tissue]ENSG00000108691-CCL2 [tissue]
HPRD01149
Protein Interaction databases
DIP (DOE-UCLA)P13500
IntAct (EBI)P13500
BioGRIDCCL2
STRING (EMBL)CCL2
ZODIACCCL2
Ontologies - Pathways
QuickGOP13500
Ontology : AmiGOMAPK cascade  angiogenesis  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  signaling receptor binding  protein binding  extracellular region  extracellular region  extracellular space  protein phosphorylation  chemotaxis  inflammatory response  inflammatory response  humoral immune response  cytoskeleton organization  cell adhesion  signal transduction  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  receptor signaling pathway via JAK-STAT  chemokine activity  regulation of cell shape  response to bacterium  animal organ morphogenesis  viral genome replication  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  sensory perception of pain  cellular homeostasis  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR2 chemokine receptor binding  CCR2 chemokine receptor binding  negative regulation of glial cell apoptotic process  helper T cell extravasation  PERK-mediated unfolded protein response  protein kinase B signaling  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  cellular response to fibroblast growth factor stimulus  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of T cell activation  positive regulation of nitric-oxide synthase biosynthetic process  positive regulation of synaptic transmission, glutamatergic  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of calcium ion import  positive regulation of NMDA glutamate receptor activity  negative regulation of vascular endothelial cell proliferation  negative regulation of G1/S transition of mitotic cell cycle  positive regulation of endothelial cell apoptotic process  positive regulation of apoptotic cell clearance  negative regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIMAPK cascade  angiogenesis  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  signaling receptor binding  protein binding  extracellular region  extracellular region  extracellular space  protein phosphorylation  chemotaxis  inflammatory response  inflammatory response  humoral immune response  cytoskeleton organization  cell adhesion  signal transduction  cell surface receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  receptor signaling pathway via JAK-STAT  chemokine activity  regulation of cell shape  response to bacterium  animal organ morphogenesis  viral genome replication  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  sensory perception of pain  cellular homeostasis  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR2 chemokine receptor binding  CCR2 chemokine receptor binding  negative regulation of glial cell apoptotic process  helper T cell extravasation  PERK-mediated unfolded protein response  protein kinase B signaling  negative regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  cellular response to fibroblast growth factor stimulus  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of T cell activation  positive regulation of nitric-oxide synthase biosynthetic process  positive regulation of synaptic transmission, glutamatergic  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of calcium ion import  positive regulation of NMDA glutamate receptor activity  negative regulation of vascular endothelial cell proliferation  negative regulation of G1/S transition of mitotic cell cycle  positive regulation of endothelial cell apoptotic process  positive regulation of apoptotic cell clearance  negative regulation of natural killer cell chemotaxis  
Pathways : BIOCARTAPertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Msp/Ron Receptor Signaling Pathway [Genes]    Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Chagas disease (American trypanosomiasis)    Malaria    Influenza A    Herpes simplex infection    Rheumatoid arthritis   
NDEx NetworkCCL2
Atlas of Cancer Signalling NetworkCCL2
Wikipedia pathwaysCCL2
Orthology - Evolution
OrthoDB6347
GeneTree (enSembl)ENSG00000108691
Phylogenetic Trees/Animal Genes : TreeFamCCL2
Homologs : HomoloGeneCCL2
Homology/Alignments : Family Browser (UCSC)CCL2
Gene fusions - Rearrangements
Fusion : MitelmanTAOK1/CCL2 [17q11.2/17q12]  
Fusion : QuiverCCL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL2
dbVarCCL2
ClinVarCCL2
MonarchCCL2
1000_GenomesCCL2 
Exome Variant ServerCCL2
GNOMAD BrowserENSG00000108691
Varsome BrowserCCL2
ACMGCCL2 variants
VarityP13500
Genomic Variants (DGV)CCL2 [DGVbeta]
DECIPHERCCL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL2 
Mutations
ICGC Data PortalCCL2 
TCGA Data PortalCCL2 
Broad Tumor PortalCCL2
OASIS PortalCCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCL2
Mutations and Diseases : HGMDCCL2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCL2
DgiDB (Drug Gene Interaction Database)CCL2
DoCM (Curated mutations)CCL2
CIViC (Clinical Interpretations of Variants in Cancer)CCL2
Cancer3DCCL2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM158105    182940    607948    609423   
Orphanet
DisGeNETCCL2
MedgenCCL2
Genetic Testing Registry CCL2
NextProtP13500 [Medical]
GENETestsCCL2
Target ValidationCCL2
Huge Navigator CCL2 [HugePedia]
ClinGenCCL2
Clinical trials, drugs, therapy
MyCancerGenomeCCL2
Protein Interactions : CTDCCL2
Pharm GKB GenePA130413151
PharosP13500
Clinical trialCCL2
Miscellaneous
canSAR (ICR)CCL2
HarmonizomeCCL2
DataMed IndexCCL2
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:02:39 CEST 2021

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