CCL2 (C-C motif chemokine ligand 2)

2003-05-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
GDCF-2,HC11,HSMCR30,MCAF,MCP-1,MCP1,SCYA2,SMC-CF
FUSION GENES

Other Information

Locus ID:

NCBI: 6347
MIM: 158105
HGNC: 10618
Ensembl: ENSG00000108691

Variants:

dbSNP: 6347
ClinVar: 6347
TCGA: ENSG00000108691
COSMIC: CCL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108691ENST00000225831P13500
ENSG00000108691ENST00000580907J3KRT7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
PERK regulates gene expressionREACTOMER-HSA-381042
ATF4 activates genesREACTOMER-HSA-380994
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783
IL-17 signaling pathwayKEGGko04657
Fluid shear stress and atherosclerosisKEGGko05418
IL-17 signaling pathwayKEGGhsa04657
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD24495780
PA451257risperidoneChemicalClinicalAnnotationassociatedPD24495780

References

Pubmed IDYearTitleCitations
194418832009Monocyte chemoattractant protein-1 (MCP-1): an overview.877
216547482011CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.752
181909122008Increased MCP-1 and microglia in various regions of the human alcoholic brain.198
164365952006CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.195
184397512008The inflammatory chemokines CCL2 and CCL5 in breast cancer.186
198337262009CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.184
219307702011Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.170
206810572010The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.137
199042832010Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks.136
127530882003MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis.131

Citation

Dessen P

CCL2 (C-C motif chemokine ligand 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/942/ccl2