CCL2 (C-C motif chemokine ligand 2)

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CCL2 (C-C motif chemokine ligand 2)

Identity

Alias_names	SCYA2
	small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
	chemokine (C-C motif) ligand 2
Alias_symbol (synonym)	MCP1
	MCP-1
	MCAF
	SMC-CF
	GDCF-2
	HC11
	MGC9434
Other alias	HSMCR30
HGNC (Hugo)	CCL2
LocusID (NCBI)	6347
Atlas_Id	942
Location	17q12 [Link to chromosome band 17q12]
Location_base_pair	Starts at 34255277 and ends at 34257201 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2016)

TAOK1 (17q11.2) / CCL2 (17q12)

TAOK1 17q11.2 / CCL2 17q12

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CCL2 10618
	Cards
Entrez_Gene (NCBI)	CCL2 6347 C-C motif chemokine ligand 2
Aliases	GDCF-2; HC11; HSMCR30; MCAF;
	MCP-1; MCP1; SCYA2; SMC-CF
GeneCards (Weizmann)	CCL2
Ensembl hg19 (Hinxton)	ENSG00000108691 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000108691 [Gene_View] chr17:34255277-34257201 [Contig_View] CCL2 [Vega]
ICGC DataPortal	ENSG00000108691
TCGA cBioPortal	CCL2
AceView (NCBI)	CCL2
Genatlas (Paris)	CCL2
WikiGenes	6347
SOURCE (Princeton)	CCL2
Genetics Home Reference (NIH)	CCL2
	Genomic and cartography
GoldenPath hg38 (UCSC)	CCL2 - chr17:34255277-34257201 + 17q12 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	CCL2 - 17q12 [Description] (hg19-Feb_2009)
Ensembl	CCL2 - 17q12 [CytoView hg19] CCL2 - 17q12 [CytoView hg38]
Mapping of homologs : NCBI	CCL2 [Mapview hg19] CCL2 [Mapview hg38]
OMIM	158105 182940 607948 609423
	Gene and transcription
Genbank (Entrez)	AK311960 AV733621 BC009716 BG530064 BT007329
RefSeq transcript (Entrez)	NM_002982
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	CCL2
Cluster EST : Unigene	Hs.303649 [ NCBI ]
CGAP (NCI)	Hs.303649
Alternative Splicing Gallery	ENSG00000108691
Gene Expression	CCL2 [ NCBI-GEO ] CCL2 [ EBI - ARRAY_EXPRESS ] CCL2 [ SEEK ] CCL2 [ MEM ]
Gene Expression Viewer (FireBrowse)	CCL2 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevisible	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	6347
GTEX Portal (Tissue expression)	CCL2
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P13500 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P13500 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P13500
Splice isoforms : SwissVar	P13500
PhosPhoSitePlus	P13500
Domaine pattern : Prosite (Expaxy)	SMALL_CYTOKINES_CC (PS00472)
Domains : Interpro (EBI)	Chemokine_CC_CS Chemokine_IL8-like_dom
Domain families : Pfam (Sanger)	IL8 (PF00048)
Domain families : Pfam (NCBI)	pfam00048
Domain families : Smart (EMBL)	SCY (SM00199)
Conserved Domain (NCBI)	CCL2
DMDM Disease mutations	6347
Blocks (Seattle)	CCL2
PDB (SRS)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB (PDBSum)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB (IMB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
PDB (RSDB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
Structural Biology KnowledgeBase	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
SCOP (Structural Classification of Proteins)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
CATH (Classification of proteins structures)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9
Superfamily	P13500
Human Protein Atlas	ENSG00000108691
Peptide Atlas	P13500
HPRD	01149
IPI	IPI00009308
	Protein Interaction databases
DIP (DOE-UCLA)	P13500
IntAct (EBI)	P13500
FunCoup	ENSG00000108691
BioGRID	CCL2
STRING (EMBL)	CCL2
ZODIAC	CCL2
	Ontologies - Pathways
QuickGO	P13500
Ontology : AmiGO	MAPK cascade angiogenesis response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response chronic inflammatory response monocyte chemotaxis positive regulation of cellular extravasation protein kinase activity receptor binding extracellular region extracellular region extracellular space rough endoplasmic reticulum protein phosphorylation cellular calcium ion homeostasis chemotaxis inflammatory response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging chemokine activity heparin binding regulation of cell shape response to heat response to wounding response to mechanical stimulus response to bacterium animal organ morphogenesis response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis viral genome replication cytokine-mediated signaling pathway cellular homeostasis endocytic vesicle dendrite neutrophil chemotaxis animal organ regeneration lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 negative regulation of glial cell apoptotic process helper T cell extravasation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus PERK-mediated unfolded protein response response to amino acid perikaryon protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration axon terminus C-fiber cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis perinuclear region of cytoplasm positive regulation of synaptic transmission positive regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in female pregnancy maternal process involved in parturition chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to ATP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to fatty acid cellular response to high density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of wound healing positive regulation of protein targeting to membrane response to cyclosporin A positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Ontology : EGO-EBI	MAPK cascade angiogenesis response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response chronic inflammatory response monocyte chemotaxis positive regulation of cellular extravasation protein kinase activity receptor binding extracellular region extracellular region extracellular space rough endoplasmic reticulum protein phosphorylation cellular calcium ion homeostasis chemotaxis inflammatory response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging chemokine activity heparin binding regulation of cell shape response to heat response to wounding response to mechanical stimulus response to bacterium animal organ morphogenesis response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis viral genome replication cytokine-mediated signaling pathway cellular homeostasis endocytic vesicle dendrite neutrophil chemotaxis animal organ regeneration lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 negative regulation of glial cell apoptotic process helper T cell extravasation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus PERK-mediated unfolded protein response response to amino acid perikaryon protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity astrocyte cell migration axon terminus C-fiber cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis perinuclear region of cytoplasm positive regulation of synaptic transmission positive regulation of T cell activation positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in female pregnancy maternal process involved in parturition chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to ATP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to fatty acid cellular response to high density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of calcium ion import positive regulation of wound healing positive regulation of protein targeting to membrane response to cyclosporin A positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Pathways : BIOCARTA	Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes] Msp/Ron Receptor Signaling Pathway [Genes] Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]
Pathways : KEGG
NDEx Network	CCL2
Atlas of Cancer Signalling Network	CCL2
Wikipedia pathways	CCL2
	Orthology - Evolution
OrthoDB	6347
GeneTree (enSembl)	ENSG00000108691
Phylogenetic Trees/Animal Genes : TreeFam	CCL2
HOVERGEN	P13500
HOGENOM	P13500
Homologs : HomoloGene	CCL2
Homology/Alignments : Family Browser (UCSC)	CCL2
	Gene fusions - Rearrangements
Fusion : Mitelman	TAOK1/CCL2 [17q11.2/17q12] [t(17;17)(q11;q12)]
Fusion: TCGA	TAOK1 17q11.2 CCL2 17q12 BRCA
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	CCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CCL2
dbVar	CCL2
ClinVar	CCL2
1000_Genomes	CCL2
Exome Variant Server	CCL2
ExAC (Exome Aggregation Consortium)	CCL2 (select the gene name)
Genetic variants : HAPMAP	6347
Genomic Variants (DGV)	CCL2 [DGVbeta]
DECIPHER	CCL2 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	CCL2
	Mutations
ICGC Data Portal	CCL2
TCGA Data Portal	CCL2
Broad Tumor Portal	CCL2
OASIS Portal	CCL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	CCL2 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	CCL2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMuta	search CCL2
DgiDB (Drug Gene Interaction Database)	CCL2
DoCM (Curated mutations)	CCL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	CCL2 (select a term)
intoGen	CCL2
Cancer3D	CCL2(select the gene name)
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	158105 182940 607948 609423
Orphanet
Medgen	CCL2
Genetic Testing Registry	CCL2
NextProt	P13500 [Medical]
TSGene	6347
GENETests	CCL2
Target Validation	CCL2
Huge Navigator	CCL2 [HugePedia]
snp3D : Map Gene to Disease	6347
BioCentury BCIQ	CCL2
ClinGen	CCL2
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	6347
Chemical/Pharm GKB Gene	PA130413151
Clinical trial	CCL2
	Miscellaneous
canSAR (ICR)	CCL2 (select the gene name)
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	CCL2
EVEX	CCL2
GoPubMed	CCL2
iHOP	CCL2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Sep 25 19:00:55 CEST 2017

Home Genes Leukemias Solid Tumors Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

CCL2 (C-C motif chemokine ligand 2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute