Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CCL2 (chemokine (C-C motif) ligand 2)

Identity

Other namesGDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
HGNC (Hugo) CCL2
LocusID (NCBI) 6347
Location 17q12
Location_base_pair Starts at 32582296 and ends at 32584220 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CCL2   10618
Entrez_Gene (NCBI)CCL2  6347  chemokine (C-C motif) ligand 2
Cards
GeneCards (Weizmann)CCL2
Ensembl (Hinxton)ENSG00000108691 [Gene_View]  chr17:32582296-32584220 [Contig_View]  CCL2 [Vega]
AceView (NCBI)CCL2
Genatlas (Paris)CCL2
SOURCE (Stanford)NM_002982
Genomic and cartography
GoldenPath (UCSC)CCL2  -  17q12   chr17:32582296-32584220 +  17q12   [Description]    (hg19-Feb_2009)
EnsemblCCL2 - 17q12 [CytoView]
Mapping of homologs : NCBICCL2 [Mapview]
OMIM158105   182940   607948   609423   
Gene and transcription
Genbank (Entrez)AK311960 AV733621 BC009716 BG530064 BT007329
RefSeq transcript (SRS)NM_002982
RefSeq transcript (Entrez)NM_002982
RefSeq genomic (SRS)AC_000149 NC_000017 NC_018928 NG_012123 NT_010799 NW_001838432 NW_004078092
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_012123 NT_010799 NW_001838432 NW_004078092
Consensus coding sequences : CCDS (NCBI)CCL2
Cluster EST : UnigeneHs.303649 [ SRS ] Hs.303649 [ NCBI ]
CGAP (NCI)Hs.303649
Alternative Splicing : Fast-db (Paris)GSHG0012398
Alternative Splicing GalleryENSG00000108691
Gene ExpressionCCL2 [ NCBI-GEO ]   CCL2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13500 (SRS) P13500 (Uniprot)
NextProtP13500
With graphics : InterProP13500
Splice isoforms : SwissVarP13500(Swissvar)
Domaine pattern : Prosite (SRS)SMALL_CYTOKINES_CC (PS00472)   
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (SRS)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Related proteins : CluSTrP13500
Domain families : Pfam (SRS)IL8 (PF00048)   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM6347
Blocks (Seattle)P13500
PDB (SRS)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4   
PDB (PDBSum)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4   
PDB (IMB)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4   
PDB (RSDB)1DOK    1DOL    1DOM    1DON    1MCA    1ML0    2BDN    2NZ1    3IFD    4DN4   
Human Protein AtlasENSG00000108691
HPRD01149
IPIIPI00009308   
Protein Interaction databases
DIP (DOE-UCLA)P13500
IntAct (EBI)P13500
FunCoupENSG00000108691
REACTOMECCL2
Protein Interaction Database6347
BioGRIDCCL2
InParanoidP13500
Interologous Interaction database P13500
IntegromeDBCCL2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CCL2
SNP (GeneSNP Utah)CCL2
SNP : HGBaseCCL2
Genetic variants : HAPMAPCCL2
Somatic Mutations in Cancer : COSMICCCL2 
CONAN: Copy Number AnalysisCCL2 
Mutations and Diseases : HGMDCCL2
OMIM158105    182940    607948    609423   
GENETests158105    182940    607948    609423   
Disease Genetic AssociationCCL2
Huge Navigator CCL2 [HugePedia]  CCL2 [HugeCancerGEM]
Genomic VariantsCCL2  CCL2 [DGVbeta]
snp3D : Map Gene to Disease6347
General knowledge
Homologs : HomoloGeneCCL2
Homology/Alignments : Family Browser (UCSC)CCL2
Phylogenetic Trees/Animal Genes : TreeFamCCL2
Chemical/Protein Interactions : CTD6347
Chemical/Pharm GKB GenePA130413151
Clinical trialCCL2
Cancer Resource (Charite)ENSG00000108691
Ontology : AmiGOMAPK cascade  angiogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  monocyte chemotaxis  protein kinase activity  receptor binding  extracellular region  extracellular region  extracellular space  cytoplasm  protein phosphorylation  cellular calcium ion homeostasis  chemotaxis  inflammatory response  humoral immune response  activation of signaling protein activity involved in unfolded protein response  cytoskeleton organization  cell adhesion  signal transduction  cell surface receptor signaling pathway  transforming growth factor beta receptor signaling pathway  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  JAK-STAT cascade  aging  chemokine activity  heparin binding  regulation of cell shape  response to heat  response to mechanical stimulus  response to bacterium  organ morphogenesis  response to gamma radiation  regulation of vascular endothelial growth factor production  positive regulation of macrophage chemotaxis  response to activity  negative regulation of angiogenesis  viral genome replication  cytokine-mediated signaling pathway  cellular homeostasis  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  organ regeneration  lipopolysaccharide-mediated signaling pathway  CCR2 chemokine receptor binding  CCR2 chemokine receptor binding  response to progesterone stimulus  response to vitamin B3  helper T cell extravasation  response to drug  neuronal cell body  negative regulation of apoptotic process  response to amino acid stimulus  protein kinase B signaling cascade  astrocyte cell migration  cellular response to fibroblast growth factor stimulus  response to ethanol  response to antibiotic  vascular endothelial growth factor receptor signaling pathway  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of synaptic transmission  positive regulation of T cell activation  response to glucocorticoid stimulus  positive regulation of nitric-oxide synthase biosynthetic process  maternal process involved in parturition  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of immune complex clearance by monocytes and macrophages  positive regulation of apoptotic cell clearance  negative regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIMAPK cascade  angiogenesis  response to hypoxia  positive regulation of endothelial cell proliferation  monocyte chemotaxis  protein kinase activity  receptor binding  extracellular region  extracellular region  extracellular space  cytoplasm  protein phosphorylation  cellular calcium ion homeostasis  chemotaxis  inflammatory response  humoral immune response  activation of signaling protein activity involved in unfolded protein response  cytoskeleton organization  cell adhesion  signal transduction  cell surface receptor signaling pathway  transforming growth factor beta receptor signaling pathway  G-protein coupled receptor signaling pathway  G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  JAK-STAT cascade  aging  chemokine activity  heparin binding  regulation of cell shape  response to heat  response to mechanical stimulus  response to bacterium  organ morphogenesis  response to gamma radiation  regulation of vascular endothelial growth factor production  positive regulation of macrophage chemotaxis  response to activity  negative regulation of angiogenesis  viral genome replication  cytokine-mediated signaling pathway  cellular homeostasis  neutrophil chemotaxis  endoplasmic reticulum unfolded protein response  organ regeneration  lipopolysaccharide-mediated signaling pathway  CCR2 chemokine receptor binding  CCR2 chemokine receptor binding  response to progesterone stimulus  response to vitamin B3  helper T cell extravasation  response to drug  neuronal cell body  negative regulation of apoptotic process  response to amino acid stimulus  protein kinase B signaling cascade  astrocyte cell migration  cellular response to fibroblast growth factor stimulus  response to ethanol  response to antibiotic  vascular endothelial growth factor receptor signaling pathway  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of synaptic transmission  positive regulation of T cell activation  response to glucocorticoid stimulus  positive regulation of nitric-oxide synthase biosynthetic process  maternal process involved in parturition  chemokine-mediated signaling pathway  cellular response to lipopolysaccharide  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of immune complex clearance by monocytes and macrophages  positive regulation of apoptotic cell clearance  negative regulation of natural killer cell chemotaxis  
Pathways : BIOCARTAPertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Msp/Ron Receptor Signaling Pathway [Genes]    Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneCCL2
iHOPCCL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:35:09 CEST 2013
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