CCL2 (chemokine (C-C motif) ligand 2)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

CCL2 (chemokine (C-C motif) ligand 2)

Identity

Other names	GDCF-2
	HC11
	HSMCR30
	MCAF
	MCP-1
	MCP1
	SCYA2
	SMC-CF
HGNC (Hugo)	CCL2
LocusID (NCBI)	6347
Location	17q12
Location_base_pair	Starts at 32582296 and ends at 32584220 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CCL2 10618
	Cards
Entrez_Gene (NCBI)	CCL2 6347 chemokine (C-C motif) ligand 2
GeneCards (Weizmann)	CCL2
Ensembl hg19 (Hinxton)	ENSG00000108691 [Gene_View] chr17:32582296-32584220 [Contig_View] CCL2 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000108691 [Gene_View] chr17:32582296-32584220 [Contig_View] CCL2 [Vega]
ICGC DataPortal	ENSG00000108691
cBioPortal	CCL2
AceView (NCBI)	CCL2
Genatlas (Paris)	CCL2
WikiGenes	6347
SOURCE (Princeton)	CCL2
	Genomic and cartography
GoldenPath hg19 (UCSC)	CCL2 - chr17:32582296-32584220 + 17q12 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	CCL2 - 17q12 [Description] (hg38-Dec_2013)
Ensembl	CCL2 - 17q12 [CytoView hg19] CCL2 - 17q12 [CytoView hg38]
Mapping of homologs : NCBI	CCL2 [Mapview hg19] CCL2 [Mapview hg38]
OMIM	158105 182940 607948 609423
	Gene and transcription
Genbank (Entrez)	AK311960 AV733621 BC009716 BG530064 BT007329
RefSeq transcript (Entrez)	NM_002982
RefSeq genomic (Entrez)	AC_000149 NC_000017 NC_018928 NG_012123 NT_010783 NW_001838432 NW_004929407
Consensus coding sequences : CCDS (NCBI)	CCL2
Cluster EST : Unigene	Hs.303649 [ NCBI ]
CGAP (NCI)	Hs.303649
Alternative Splicing : Fast-db (Paris)	GSHG0012398
Alternative Splicing Gallery	ENSG00000108691
Gene Expression	CCL2 [ NCBI-GEO ] CCL2 [ SEEK ] CCL2 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P13500 (Uniprot)
NextProt	P13500 [Medical]
With graphics : InterPro	P13500
Splice isoforms : SwissVar	P13500 (Swissvar)
Domaine pattern : Prosite (Expaxy)	SMALL_CYTOKINES_CC (PS00472)
Domains : Interpro (EBI)	Chemokine_CC_CS Chemokine_IL8-like_dom
Related proteins : CluSTr	P13500
Domain families : Pfam (Sanger)	IL8 (PF00048)
Domain families : Pfam (NCBI)	pfam00048
Domain families : Smart (EMBL)	SCY (SM00199)
DMDM Disease mutations	6347
Blocks (Seattle)	P13500
PDB (SRS)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
PDB (PDBSum)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
PDB (IMB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
PDB (RSDB)	1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
Human Protein Atlas	ENSG00000108691
Peptide Atlas	P13500
HPRD	01149
IPI	IPI00009308
	Protein Interaction databases
DIP (DOE-UCLA)	P13500
IntAct (EBI)	P13500
FunCoup	ENSG00000108691
BioGRID	CCL2
IntegromeDB	CCL2
STRING (EMBL)	CCL2
	Ontologies - Pathways
QuickGO	P13500
Ontology : AmiGO	MAPK cascade angiogenesis response to hypoxia positive regulation of endothelial cell proliferation monocyte chemotaxis protein kinase activity receptor binding extracellular region extracellular region extracellular space cytoplasm protein phosphorylation cellular calcium ion homeostasis chemotaxis inflammatory response humoral immune response activation of signaling protein activity involved in unfolded protein response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging chemokine activity heparin binding regulation of cell shape response to heat response to mechanical stimulus response to bacterium organ morphogenesis response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis viral genome replication cytokine-mediated signaling pathway cellular homeostasis neutrophil chemotaxis endoplasmic reticulum unfolded protein response organ regeneration lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding response to progesterone response to vitamin B3 negative regulation of glial cell apoptotic process helper T cell extravasation response to drug neuronal cell body response to amino acid protein kinase B signaling negative regulation of neuron apoptotic process astrocyte cell migration cellular protein metabolic process cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis positive regulation of synaptic transmission positive regulation of T cell activation response to glucocorticoid positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in parturition chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of immune complex clearance by monocytes and macrophages positive regulation of calcium ion import positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Ontology : EGO-EBI	MAPK cascade angiogenesis response to hypoxia positive regulation of endothelial cell proliferation monocyte chemotaxis protein kinase activity receptor binding extracellular region extracellular region extracellular space cytoplasm protein phosphorylation cellular calcium ion homeostasis chemotaxis inflammatory response humoral immune response activation of signaling protein activity involved in unfolded protein response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway transforming growth factor beta receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade aging chemokine activity heparin binding regulation of cell shape response to heat response to mechanical stimulus response to bacterium organ morphogenesis response to gamma radiation regulation of vascular endothelial growth factor production positive regulation of macrophage chemotaxis response to activity negative regulation of angiogenesis viral genome replication cytokine-mediated signaling pathway cellular homeostasis neutrophil chemotaxis endoplasmic reticulum unfolded protein response organ regeneration lipopolysaccharide-mediated signaling pathway CCR2 chemokine receptor binding CCR2 chemokine receptor binding response to progesterone response to vitamin B3 negative regulation of glial cell apoptotic process helper T cell extravasation response to drug neuronal cell body response to amino acid protein kinase B signaling negative regulation of neuron apoptotic process astrocyte cell migration cellular protein metabolic process cellular response to fibroblast growth factor stimulus response to ethanol response to antibiotic vascular endothelial growth factor receptor signaling pathway macrophage chemotaxis lymphocyte chemotaxis positive regulation of synaptic transmission positive regulation of T cell activation response to glucocorticoid positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in parturition chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to tumor necrosis factor cellular response to organic cyclic compound positive regulation of immune complex clearance by monocytes and macrophages positive regulation of calcium ion import positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis
Pathways : BIOCARTA	Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes] Msp/Ron Receptor Signaling Pathway [Genes] Low-density lipoprotein (LDL) pathway during atherogenesis [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction Chemokine signaling pathway NOD-like receptor signaling pathway TNF signaling pathway Chagas disease (American trypanosomiasis) Malaria Influenza A Herpes simplex infection Rheumatoid arthritis
Protein Interaction Database	CCL2
DoCM (Curated mutations)	CCL2
Wikipedia pathways	CCL2
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	CCL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CCL2
dbVar	CCL2
ClinVar	CCL2
1000_Genomes	CCL2
Exome Variant Server	CCL2
SNP (GeneSNP Utah)	CCL2
SNP : HGBase	CCL2
Genetic variants : HAPMAP	CCL2
Genomic Variants (DGV)	CCL2 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000108691
Somatic Mutations in Cancer : COSMIC	CCL2
CONAN: Copy Number Analysis	CCL2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	TBsLVD Tuberculosis susceptibility Locus Variation Database
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	17:32582296-32584220
Mutations and Diseases : HGMD	CCL2
OMIM	158105 182940 607948 609423
Medgen	CCL2
NextProt	P13500 [Medical]
GENETests	CCL2
Disease Genetic Association	CCL2
Huge Navigator	CCL2 [HugePedia] CCL2 [HugeCancerGEM]
snp3D : Map Gene to Disease	6347
DGIdb (Drug Gene Interaction db)	CCL2
	General knowledge
Homologs : HomoloGene	CCL2
Homology/Alignments : Family Browser (UCSC)	CCL2
Phylogenetic Trees/Animal Genes : TreeFam	CCL2
Chemical/Protein Interactions : CTD	6347
Chemical/Pharm GKB Gene	PA130413151
Clinical trial	CCL2
Cancer Resource (Charite)	ENSG00000108691
	Other databases
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
CoreMine	CCL2
GoPubMed	CCL2
iHOP	CCL2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 15:04:41 CET 2015

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