CCL22 (C-C motif chemokine ligand 22)

2007-02-01  

Identity

HGNC
LOCATION
16q21
LOCUSID
ALIAS
A-152E5.1,ABCD-1,DC/B-CK,MDC,SCYA22,STCP-1
FUSION GENES

Other Information

Locus ID:

NCBI: 6367
MIM: 602957
HGNC: 10621
Ensembl: ENSG00000102962

Variants:

dbSNP: 6367
ClinVar: 6367
TCGA: ENSG00000102962
COSMIC: CCL22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102962ENST00000219235O00626

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

References

Pubmed IDYearTitleCitations
159443272005Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.231
192441252009Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.192
229753732012TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.155
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
182246872008CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer.104
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
119818282002Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.62
147475322004Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus.45
151135902004Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.39
158138162005Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis.29

Citation

Dessen P

CCL22 (C-C motif chemokine ligand 22)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46211/ccl22